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Protein

Cell invasion protein SipD

Gene

sipD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC.2 Publications

GO - Biological processi

Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-2911-MONOMER

Protein family/group databases

TCDBi1.C.36.3.2 the bacterial type iii-target cell pore (iiitcp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cell invasion protein SipD
Alternative name(s):
Salmonella invasion protein D
Gene namesi
Name:sipD
Synonyms:sspD
Ordered Locus Names:STM2883
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Secreted 1 Publication
  • Note: Secreted via the type III secretion system 1 (SPI-1 TTSS).

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002198651 – 343Cell invasion protein SipDAdd BLAST343

Proteomic databases

PaxDbiQ56026
PRIDEiQ56026

Expressioni

Inductioni

Transcriptionally regulated by SicA and InvF. Also regulated by InvE.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2883

Structurei

Secondary structure

1343
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ56026
SMRiQ56026
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56026

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili295 – 322Sequence analysisAdd BLAST28

Domaini

The N-terminal domain is an intra-molecular chaperone that prevents premature oligomerization of the residues on the coiled-coil region that are involved in interactions with the needle and/or itself. The residues in the C-terminal domain probably form oligomeric structures at the tip of the needle that are responsible for the regulation of secretion of other effectors (By similarity).By similarity

Sequence similaritiesi

Belongs to the invasin protein D family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4105IBT Bacteria
ENOG4111P3X LUCA
HOGENOMiHOG000028233
KOiK13287
OMAiNYLGVYE

Family and domain databases

Gene3Di1.20.1710.10, 1 hit
InterProiView protein in InterPro
IPR036708 BipD-like_sf
IPR009483 Plasmid_invsIpaD
PfamiView protein in Pfam
PF06511 IpaD, 1 hit
SUPFAMiSSF140693 SSF140693, 1 hit
TIGRFAMsiTIGR02553 SipD_IpaD_SspD, 1 hit

Sequencei

Sequence statusi: Complete.

Q56026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNIQNYSAS PHPGIVAERP QTPSASEHVE TAVVPSTTEH RGTDIISLSQ
60 70 80 90 100
AATKIHQAQQ TLQSTPPISE ENNDERTLAR QQLTSSLNAL AKSGVSLSAE
110 120 130 140 150
QNENLRSAFS APTSALFSAS PMAQPRTTIS DAEIWDMVSQ NISAIGDSYL
160 170 180 190 200
GVYENVVAVY TDFYQAFSDI LSKMGGWLLP GKDGNTVKLD VTSLKNDLNS
210 220 230 240 250
LVNKYNQINS NTVLFPAQSG SGVKVATEAE ARQWLSELNL PNSCLKSYGS
260 270 280 290 300
GYVVTVDLTP LQKMVQDIDG LGAPGKDSKL EMDNAKYQAW QSGFKAQEEN
310 320 330 340
MKTTLQTLTQ KYSNANSLYD NLVKVLSSTI SSSLETAKSF LQG
Length:343
Mass (Da):37,112
Last modified:November 1, 1996 - v1
Checksum:i4B8E46419114219F
GO

Sequence cautioni

The sequence AAA86617 differs from that shown. Reason: Frameshift at position 333.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti292S → A in AAA86617 (PubMed:8522512).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30491 Genomic DNA Translation: AAC43548.1
U40013 Genomic DNA Translation: AAA86617.1 Frameshift.
AE006468 Genomic DNA Translation: AAL21763.1
PIRiS70549
RefSeqiNP_461804.1, NC_003197.2
WP_000932246.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL21763; AAL21763; STM2883
GeneIDi1254406
KEGGistm:STM2883
PATRICifig|99287.12.peg.3039

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30491 Genomic DNA Translation: AAC43548.1
U40013 Genomic DNA Translation: AAA86617.1 Frameshift.
AE006468 Genomic DNA Translation: AAL21763.1
PIRiS70549
RefSeqiNP_461804.1, NC_003197.2
WP_000932246.1, NC_003197.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YM0X-ray3.00A/B132-343[»]
2YM9X-ray3.00A/B/C/D1-343[»]
3NZZX-ray1.65A/B39-343[»]
3O00X-ray1.85A/B39-343[»]
3O01X-ray1.90A/B39-343[»]
3O02X-ray1.90A/B39-343[»]
3ZQBX-ray2.40A/B127-343[»]
3ZQEX-ray2.19A/B127-343[»]
ProteinModelPortaliQ56026
SMRiQ56026
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2883

Protein family/group databases

TCDBi1.C.36.3.2 the bacterial type iii-target cell pore (iiitcp) family

Proteomic databases

PaxDbiQ56026
PRIDEiQ56026

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21763; AAL21763; STM2883
GeneIDi1254406
KEGGistm:STM2883
PATRICifig|99287.12.peg.3039

Phylogenomic databases

eggNOGiENOG4105IBT Bacteria
ENOG4111P3X LUCA
HOGENOMiHOG000028233
KOiK13287
OMAiNYLGVYE

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-2911-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ56026

Family and domain databases

Gene3Di1.20.1710.10, 1 hit
InterProiView protein in InterPro
IPR036708 BipD-like_sf
IPR009483 Plasmid_invsIpaD
PfamiView protein in Pfam
PF06511 IpaD, 1 hit
SUPFAMiSSF140693 SSF140693, 1 hit
TIGRFAMsiTIGR02553 SipD_IpaD_SspD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIPD_SALTY
AccessioniPrimary (citable) accession number: Q56026
Secondary accession number(s): Q56033, Q7CPX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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