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Protein

Proteasome subunit beta type-6

Gene

psmB6

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.1 Publication

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.010

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-6 (EC:3.4.25.1)
Alternative name(s):
Differentiation-associated proteasome subunit 1
Short name:
DAPS-1
Gene namesi
Name:psmB6
Synonyms:dapA
ORF Names:DDB_G0267390
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0267390 psmB6

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • nucleus Source: dictyBase
  • proteasome core complex, beta-subunit complex Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003273841 – 14Removed in mature form1 PublicationAdd BLAST14
ChainiPRO_000032738515 – 214Proteasome subunit beta type-6Add BLAST200

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiQ55GJ6
PRIDEiQ55GJ6

Expressioni

Developmental stagei

Maximally expressed 4-6 hours after starvation (around the aggregation-stream stage), followed by a drastic decrease from the mound to tipped aggregate stage.1 Publication

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0191199

Structurei

3D structure databases

ProteinModelPortaliQ55GJ6
SMRiQ55GJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0174 Eukaryota
ENOG410XS23 LUCA
InParanoidiQ55GJ6
KOiK02738
OMAiHDRIYCC
PhylomeDBiQ55GJ6

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR000243 Pept_T1A_subB
IPR037559 Proteasome_beta_Pre3
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF4 PTHR11599:SF4, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55GJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPEWLDNA VDLGTSIMAV EYDGGVIMGA DSRTTTGAYI ANRVTNKITP
60 70 80 90 100
IHERIYCCRS GSAADTQAIS DYVRYYLEMH TSELCDEPDV KTAASLFQLL
110 120 130 140 150
CYSNKNNLMA GIIVAGWDKH QGGSVYNISL GGSMVKQPFA IGGSGSTYIY
160 170 180 190 200
GYCDSKFKPK MTKDECIEFV QNSLALAMFR DGSSGGVIRL CIIDKNGVER
210
KMIPGNNLPR FWEG
Length:214
Mass (Da):23,446
Last modified:May 24, 2005 - v1
Checksum:i1EA0E6921D37AAE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25G → R AA sequence (PubMed:8130037).Curated1
Sequence conflicti28M → A AA sequence (PubMed:8130037).Curated1
Sequence conflicti95S → C in BAA25923 (PubMed:9535814).Curated1
Sequence conflicti122Missing in BAA25923 (PubMed:9535814).Curated1
Sequence conflicti165E → R in BAA25923 (PubMed:9535814).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007024 mRNA Translation: BAA25923.1
AAFI02000003 Genomic DNA Translation: EAL73147.1
PIRiJE0101
RefSeqiXP_647188.1, XM_642096.1

Genome annotation databases

EnsemblProtistsiEAL73147; EAL73147; DDB_G0267390
GeneIDi8615992
KEGGiddi:DDB_G0267390

Similar proteinsi

Entry informationi

Entry nameiPSB6_DICDI
AccessioniPrimary (citable) accession number: Q55GJ6
Secondary accession number(s): O60953
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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