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UniProtKB - Q55F69 (ALG3_DICDI)
Protein
Probable Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
Gene
alg3
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.
By similarityCatalytic activityi
- α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl β-D-mannosyl phosphate = α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+EC:2.4.1.258
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- alpha-1,3-mannosyltransferase activity Source: dictyBase
- dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity Source: GO_Central
GO - Biological processi
- protein glycosylation Source: dictyBase
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
Reactomei | R-DDI-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
UniPathwayi | UPA00378 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC:2.4.1.258)Alternative name(s): Asparagine-linked glycosylation protein 3 homolog Dol-P-Man-dependent alpha(1-3)-mannosyltransferase Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase |
Gene namesi | Name:alg3 ORF Names:DDB_G0268238 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0268238, alg3 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: dictyBase
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 177 – 197 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 214 – 234 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 294 – 314 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 336 – 356 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 372 – 392 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 407 – 427 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000327763 | 1 – 446 | Probable Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferaseAdd BLAST | 446 |
Proteomic databases
PaxDbi | Q55F69 |
Structurei
3D structure databases
AlphaFoldDBi | Q55F69 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 58 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2762, Eukaryota |
HOGENOMi | CLU_035382_3_0_1 |
InParanoidi | Q55F69 |
OMAi | PERYGIH |
PhylomeDBi | Q55F69 |
Family and domain databases
InterProi | View protein in InterPro IPR007873, Glycosyltransferase_ALG3 |
PANTHERi | PTHR12646, PTHR12646, 1 hit |
Pfami | View protein in Pfam PF05208, ALG3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q55F69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIENKVLPFI KNNQIKCFYT LASFLMIYEL CINKIIIDYV KYTEIDWSTY
60 70 80 90 100
VQQVEVFLKG IYDYTKIEGD TGPCVYPAGH LYVFSLLYNL TENGLNILKA
110 120 130 140 150
QYIFAAIYIL LTFIVFSIYG ESIKESIKQI TNKSNNNNNN NNNNNNNNNN
160 170 180 190 200
VFLKIPFYII IFLCLSKRIH SIFALRMFND CISMLLFYIS LYLIIKGRWN
210 220 230 240 250
LGCLFFSCSV SVKMNVLLYS PALLFLLLST FGIWRTIPKL MICGLVQVLL
260 270 280 290 300
AIPFLMVNPQ GYLLRAFEFS RQFLYKWTVN WRFLPEHLFL NKSWALFLLS
310 320 330 340 350
IHLLFIILFF IKYIKKEQGG ISNILKRGSI NQNPKLLSVN YILLIMFTIN
360 370 380 390 400
LIGVTFSRSL HYQFYLWYFH TLPFLLWSTN YNLFLKIGFM CITEYAWNTY
410 420 430 440
PSTSTSSLML FISNFILLIQ LYFQPTINSL REDKNNSSGL KKKKTK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000003 Genomic DNA Translation: EAL73572.1 |
RefSeqi | XP_647664.1, XM_642572.1 |
Genome annotation databases
EnsemblProtistsi | EAL73572; EAL73572; DDB_G0268238 |
GeneIDi | 8616481 |
KEGGi | ddi:DDB_G0268238 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000003 Genomic DNA Translation: EAL73572.1 |
RefSeqi | XP_647664.1, XM_642572.1 |
3D structure databases
AlphaFoldDBi | Q55F69 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 44689.DDB0231368 |
Proteomic databases
PaxDbi | Q55F69 |
Genome annotation databases
EnsemblProtistsi | EAL73572; EAL73572; DDB_G0268238 |
GeneIDi | 8616481 |
KEGGi | ddi:DDB_G0268238 |
Organism-specific databases
dictyBasei | DDB_G0268238, alg3 |
Phylogenomic databases
eggNOGi | KOG2762, Eukaryota |
HOGENOMi | CLU_035382_3_0_1 |
InParanoidi | Q55F69 |
OMAi | PERYGIH |
PhylomeDBi | Q55F69 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Reactomei | R-DDI-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
Miscellaneous databases
PROi | PR:Q55F69 |
Family and domain databases
InterProi | View protein in InterPro IPR007873, Glycosyltransferase_ALG3 |
PANTHERi | PTHR12646, PTHR12646, 1 hit |
Pfami | View protein in Pfam PF05208, ALG3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALG3_DICDI | |
Accessioni | Q55F69Primary (citable) accession number: Q55F69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families