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Entry version 99 (12 Aug 2020)
Sequence version 1 (24 May 2005)
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Protein

Adenylate cyclase, terminal-differentiation specific

Gene

acrA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Through the production of cAMP, activates cAMP-dependent protein kinases (PKAs), triggering terminal differential and the production of spores.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by high osmolarity. Inhibited by caffeine and 2',5'-dideoxyadenosine (DDA).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1588Magnesium 1PROSITE-ProRule annotation1
Metal bindingi1588Magnesium 2PROSITE-ProRule annotation1
Metal bindingi1589Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi1632Magnesium 1PROSITE-ProRule annotation1
Metal bindingi1632Magnesium 2PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processcAMP biosynthesis, Sporulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylate cyclase, terminal-differentiation specific (EC:4.6.1.1)
Alternative name(s):
ACB
ATP pyrophosphate-lyase
Adenylyl cyclase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:acrA
Synonyms:acb
ORF Names:DDB_G0267376
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0267376, acrA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Transmembranei572 – 592HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cells cannot complete sporulation and have abnormally long, thin stalks, though able to aggregate and form normal slugs.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003282401 – 2123Adenylate cyclase, terminal-differentiation specificAdd BLAST2123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10104-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei11744-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q55F68

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present at low levels in growing cells; accumulates to high levels throughout development. Highly expressed during early culmination and in fruiting bodies, especially in the prestalk region.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191294

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q55F68

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini654 – 928Histidine kinasePROSITE-ProRule annotationAdd BLAST275
Domaini954 – 1076Response regulatory 1PROSITE-ProRule annotationAdd BLAST123
Domaini1125 – 1310Response regulatory 2PROSITE-ProRule annotationAdd BLAST186
Domaini1583 – 1712Guanylate cyclasePROSITE-ProRule annotationAdd BLAST130

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 26Poly-Glu7
Compositional biasi75 – 102Poly-AsnAdd BLAST28
Compositional biasi201 – 216Poly-GlnAdd BLAST16
Compositional biasi363 – 377Poly-GlnAdd BLAST15
Compositional biasi438 – 457Poly-AsnAdd BLAST20
Compositional biasi830 – 841Poly-GlnAdd BLAST12
Compositional biasi1215 – 1257Poly-AsnAdd BLAST43
Compositional biasi1443 – 1453Poly-GlnAdd BLAST11
Compositional biasi1843 – 1848Poly-Gln6
Compositional biasi1852 – 1902Poly-GlnAdd BLAST51
Compositional biasi1916 – 1971Poly-GlnAdd BLAST56
Compositional biasi1975 – 2045Poly-GlnAdd BLAST71
Compositional biasi2052 – 2090Poly-GlnAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RSS4, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_232101_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q55F68

Identification of Orthologs from Complete Genome Data

More...
OMAi
ICKSITI

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00156, REC, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054, A/G_cyclase
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR029787, Nucleotide_cyclase
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00211, Guanylate_cyc, 1 hit
PF02518, HATPase_c, 1 hit
PF00072, Response_reg, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00344, BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044, CYCc, 1 hit
SM00387, HATPase_c, 1 hit
SM00448, REC, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52172, SSF52172, 2 hits
SSF55073, SSF55073, 1 hit
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS50109, HIS_KIN, 1 hit
PS50110, RESPONSE_REGULATORY, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q55F68-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNNRLKNRK KPNQIHTISE EEEEEEPLFN NEDLQTQHLN SPSSDSISTS
60 70 80 90 100
SSSSLSSVGG SVVGNNNSNS NGIDNNNSNN NNNNNNNNNN NNNNNNSNNN
110 120 130 140 150
NNYTGNSIGG NDFKNKASSS SSTPTTSTGI GSSKFPNIKR KNSFSNRYDS
160 170 180 190 200
GGGGSGSSRS NSFGGSNSSG GASKEFFYFD NDDMIQDDDL IPMLMQDQEH
210 220 230 240 250
QLQTQYQNQQ QVQQQQNIIN SFINHENLKF PFSIIYTNKL HIWLSYFLFT
260 270 280 290 300
FVLIFCCLAV GPLLWIELPP NSGCMWCRIF KLEWVISFMS LISAMFHYTI
310 320 330 340 350
RRDMFPLYLS IIGFYHVLTY SEPFLEPFRV NNFFSLILTV ICIFIAFYPK
360 370 380 390 400
NKLRRQQASN HHQQQQQQQQ QQRQRQQNNN RQPEKSIIKR IIQNEWFHSL
410 420 430 440 450
IQILIVLGIV VLLFFSIFIL ALFMKDDKTF SGDVIDGNIN SNNNNNNNNN
460 470 480 490 500
NNINNNNIDN NNNNIKNNNK GFIEEIEQGE EQLELYLENA YHIFKELVFK
510 520 530 540 550
KFISSSVVYL ILITLLFCIS LVYHWEVRKP YTLMALASMI PQLTQALYKV
560 570 580 590 600
ELTLTGVMDK GTMSHNVTPL GGGIFYILNV ISYTSFYCGL AIDVVVASGE
610 620 630 640 650
KYKRLKKRGE KYHRRLSTQI NEQNAFVNKI YASGTAQLLQ KVEFMQKFVD
660 670 680 690 700
KILFSTLEIS NRLQRLESSD QDIPSSLVDQ LNDIQYQTNR SLLLLNDTKL
710 720 730 740 750
ILAIESGVIS REDVSVNLFD FLEDVLERTS KDIKFNNIEL VYKIDKDVPL
760 770 780 790 800
NIILDPTALT QICFQLLSNA IKYTEEGEIG ILIKRILRND YEYQQEQQQP
810 820 830 840 850
QQDNELPPFG TISEEDEEYN SNNPPPPLNQ QQQQRQQQQQ QEPKQIYLEI
860 870 880 890 900
SIFDSGPGMD DDELDICNQF QPFPDIGDED DIEIKKKGSG LGLLICNKVL
910 920 930 940 950
KSIGGDLIVE RYLETGGCIF KCCIPVLVDP QPKENFTFQI PLSQETNELL
960 970 980 990 1000
SDLSVLVIDD NPYARDSVGF IFSSVFNSAI VKSANSSVEG VRDLKYAIAT
1010 1020 1030 1040 1050
DSNFKLLLVD YHMPGCDGIE AIQMIVDNPA FSDIKIILMI LPSDSFAHMN
1060 1070 1080 1090 1100
EKTKNITTLI KPVTPTNLFN AISKTFKLKE FSSVVDLVDL NAPDTSTQIP
1110 1120 1130 1140 1150
LKRNRLKFKI DFPFRLPETG KPIMRVLIGE SDKSTQSKIQ KVIESFGYFS
1160 1170 1180 1190 1200
TFVTDGTALI SLSKKNYYDL VIVDLELQST DGFECAQIIR DTHGEIFSNT
1210 1220 1230 1240 1250
IFVPKPISTN SNDDNNNNNN NNNNNNNNDN NNNNNNNNNN NNNNNNNNNN
1260 1270 1280 1290 1300
NNNNNNNSIL TSSVDTDGNH IVSSSTSTSS SFPTRRSSIG SFQTASPSMT
1310 1320 1330 1340 1350
EISHRRRVKL PIIGIWHHSD IIPDDIIKKI KRVGFDGYCS FDNLEFYLQE
1360 1370 1380 1390 1400
FLLEFDRKRK SNILSPIRLF PNGSPSTNIY DYSSIISNLN QASGNNNNSS
1410 1420 1430 1440 1450
PISGILNENV ISSPISLDLD LNSVSSIQSQ SSSSSSSFQH NNQQQQQQQH
1460 1470 1480 1490 1500
QHQLTPTQQS IGGGNNGINQ LSFSSQQSTP IFNQSQIQHQ IISNRSKHSS
1510 1520 1530 1540 1550
LSSSTSSNGS GGSGGKSRFS IPMLPSSTNR DSSPHSSSKM ALKRVQDLES
1560 1570 1580 1590 1600
VISKFVPIEF QQLIAPSGME NVYLGDAICK SITIFFSDIR DFTSTTEKML
1610 1620 1630 1640 1650
VDDVIDFLNT YLAFALPSIT DSGGFIDKFI GDAIMAIFPN SDMKLQAINA
1660 1670 1680 1690 1700
VKAAIRMMRS LDFMSISGFR FSSVETGVGI NTGKTIIGIV GTENRMEPTA
1710 1720 1730 1740 1750
LGDAVNLASR TEQLCKEYQS RILITQFTME AIGTSIDEFV IRLVDSVTVK
1760 1770 1780 1790 1800
GKSEAVNIYE VIDGEREDKR VLKMKILPWY QNGMDLYKRH CYEEALSYFQ
1810 1820 1830 1840 1850
LCTEIMPNDK PTLIYIQRCI QNIKTLELQQ IQLQQLQRQQ LLQQQQQQLL
1860 1870 1880 1890 1900
LQQQLQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
1910 1920 1930 1940 1950
SQNIQQPQSQ QSQYVQQPQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
1960 1970 1980 1990 2000
QQQPQQQQQL QQQQQHQQQK QPSPQQQQQP QQPQQQQQQQ IQNQYQHQLQ
2010 2020 2030 2040 2050
YQRQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQHHHHH
2060 2070 2080 2090 2100
HQQQQFQQQS QQSQQQSQQQ QQQQQQQSQQ QSQQQSQQIQ KKSQHPHSQQ
2110 2120
IQSQRHQSQP QNVDTNVKTK PQQ
Length:2,123
Mass (Da):243,012
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD99245C5D8C2902B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1936Q → R in AAD50121 (PubMed:10556070).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF153362 Genomic DNA Translation: AAD50121.1
AAFI02000003 Genomic DNA Translation: EAL73140.1

NCBI Reference Sequences

More...
RefSeqi
XP_647665.1, XM_642573.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL73140; EAL73140; DDB_G0267376

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8616482

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0267376

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153362 Genomic DNA Translation: AAD50121.1
AAFI02000003 Genomic DNA Translation: EAL73140.1
RefSeqiXP_647665.1, XM_642573.1

3D structure databases

SMRiQ55F68
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191294

Proteomic databases

PaxDbiQ55F68

Genome annotation databases

EnsemblProtistsiEAL73140; EAL73140; DDB_G0267376
GeneIDi8616482
KEGGiddi:DDB_G0267376

Organism-specific databases

dictyBaseiDDB_G0267376, acrA

Phylogenomic databases

eggNOGiENOG502RSS4, Eukaryota
HOGENOMiCLU_232101_0_0_1
InParanoidiQ55F68
OMAiICKSITI

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q55F68

Family and domain databases

CDDicd00156, REC, 2 hits
Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR029787, Nucleotide_cyclase
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF00211, Guanylate_cyc, 1 hit
PF02518, HATPase_c, 1 hit
PF00072, Response_reg, 1 hit
PRINTSiPR00344, BCTRLSENSOR
SMARTiView protein in SMART
SM00044, CYCc, 1 hit
SM00387, HATPase_c, 1 hit
SM00448, REC, 2 hits
SUPFAMiSSF52172, SSF52172, 2 hits
SSF55073, SSF55073, 1 hit
SSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS50109, HIS_KIN, 1 hit
PS50110, RESPONSE_REGULATORY, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYAD_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q55F68
Secondary accession number(s): Q9U9S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: August 12, 2020
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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