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Entry version 83 (07 Oct 2020)
Sequence version 1 (24 May 2005)
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Protein

Integrator complex subunit 3 homolog

Gene

ints3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrator complex subunit 3 homolog
Alternative name(s):
SOSS complex subunit A homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ints3
ORF Names:DDB_G0268706
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0268706, ints3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003443751 – 1520Integrator complex subunit 3 homologAdd BLAST1520

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q55EZ4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0234074

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q55EZ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 10Poly-Gln7
Compositional biasi18 – 21Poly-Gln4
Compositional biasi62 – 65Poly-Leu4
Compositional biasi527 – 547Poly-GlnAdd BLAST21
Compositional biasi570 – 594Poly-GlnAdd BLAST25
Compositional biasi595 – 917Pro-richAdd BLAST323
Compositional biasi611 – 624Poly-GlnAdd BLAST14
Compositional biasi1034 – 1061Thr-richAdd BLAST28
Compositional biasi1126 – 1130Poly-Asn5
Compositional biasi1137 – 1147Poly-GlnAdd BLAST11
Compositional biasi1154 – 1174Poly-AsnAdd BLAST21
Compositional biasi1224 – 1230Poly-Pro7
Compositional biasi1420 – 1428Poly-Asn9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Integrator subunit 3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4262, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_247789_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q55EZ4

KEGG Orthology (KO)

More...
KOi
K13140

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWRDINT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019333, Int_cplx_su3

The PANTHER Classification System

More...
PANTHERi
PTHR13587, PTHR13587, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10189, Ints3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q55EZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNQQQQQQQ PPTTSPTQQQ QLTQLQTHQY FQNKFKLFYK RELDEADPLE
60 70 80 90 100
IYWRECYDKI ELLLLNSSEA EINNYLIEKS ASVESSGNND QSNKFHTEVT
110 120 130 140 150
IGFLYAILLG SPQNIALSHQ YFKSLTFFTK DSLALFCSLL KKLIADKFQK
160 170 180 190 200
LNDTPRQQVV WIINELIATN HQDCESVTSI ILRHIYGGNF TSKNLSLSHS
210 220 230 240 250
MLNMFLTHRQ WLNSRPLLIP TILYNFLRLI QDHISRPQGL HNPTHLKDEI
260 270 280 290 300
NFCLDLLKNK FQECLVIGRD LIRLLQYLST KTIEFEQLWK DLNSKPTTFA
310 320 330 340 350
PGYYDIIQSM KTPTPKHFLQ SRLSPEMELQ VLYILKEVKF GNQKRYQQWF
360 370 380 390 400
VTKYLVTPES ESLIPDIIRY ICCVYHPPNH VLCSDIVPRW AIIGWLLKHC
410 420 430 440 450
KSDAWRNYSK LSLFLDWLYF EPKIDSIMNI EPAILLMAGS VKKYADMTID
460 470 480 490 500
LVEFIVGTLL DSYDIQRKDA IRQGIHNSFA TVLEKGVVQS LSHVFPPDSL
510 520 530 540 550
GPSLFEKVKH YFHQFLTNSP IHQLHSQQQQ LQQQQLQQPQ QPQQQQQPPQ
560 570 580 590 600
YKPYPQQPIN KQLPLQMSPQ QQSQQQLQQQ QLQQQLQQQQ QQQQPPQQPP
610 620 630 640 650
PQQQPQQQPP QQQPQQQPQQ QQPQLNISTG NLPNIQQPMV KSPPLSSNTL
660 670 680 690 700
VSPTSSSSPT SSNLPTNNSR VLNKSGVDIH HVSNLSPQVI SQKPQSQQTP
710 720 730 740 750
SLHSSSQSVL QQKSPPLKET SLFEQQQPSQ QLPSQIVKNS PPNLSMTNEN
760 770 780 790 800
ISNPPPPPHA KISSDHASPL INSSNSNITT PNPDSQSQIP IPPPISQSPS
810 820 830 840 850
TKNIDVIMSE LNDEPPKLSK SSPTQSNIIV PPPTHKPPQT TISSSSPLLQ
860 870 880 890 900
PQTQPQPQTQ PQPQTLQQST TPSLSSSSTP TIPISPPLLP TQLEIDIQPP
910 920 930 940 950
PPPPSSQPLQ PPPPPPPSQN IKDETLNSLI ELNSSIKLDE EIKMEIPDIL
960 970 980 990 1000
LTIGSKPQFQ PTNITITLGS ILSNFNEKIS KQPNITLQNE LTDSLTQYLS
1010 1020 1030 1040 1050
QVLKPELQID LSTTPSLLSL FCNFQVIHHI FRATFSPTDN SITTTTTTTA
1060 1070 1080 1090 1100
AATTTTTTTP TIVKPMFNIL KELYKIYPSI GFKIMIWSII TSPGGLNITN
1110 1120 1130 1140 1150
NGCTYIYPDI ECDNSFSNSD DNESTNNNNN GVEQKPQQQQ QQQQQQQINE
1160 1170 1180 1190 1200
NTHNNNNNNN NNNNNNNNNN NENNITNNSQ NITIKEESIF KIEKLLESVQ
1210 1220 1230 1240 1250
DSNGNRNILG NYLNFHSNLL GGQPPPPPPP QQPNKIVEQI ISDCIEANNV
1260 1270 1280 1290 1300
GAFNYLVPIL YKSFSNLLVG NSDFLYLVLS CINPRQHFRI CNKISMGEFR
1310 1320 1330 1340 1350
VFGNEMKSLI SQSFKWESFE QNYLWQMLIA EDSVYSGMIV KEYPFIISKL
1360 1370 1380 1390 1400
DPYNNSEVLQ NLTITLKETK FYDFNIFSET LLLNDYFYTF VFCLFSFWLK
1410 1420 1430 1440 1450
NNTTQTFNYI NQIFDFYLSN NNNNNNNNRK LVERILYFYN IFLKKYGEER
1460 1470 1480 1490 1500
IKWSDMIDSD RVSKVLQRST NSNLFQKYSN LGSLVLPSQS SNIKNDNNPT
1510 1520
LSKHQNSDDD SNPKKRFRKE
Length:1,520
Mass (Da):173,734
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2C7B944DBE96BA1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000004 Genomic DNA Translation: EAL72942.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL72942; EAL72942; DDB_G0268706

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0268706

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000004 Genomic DNA Translation: EAL72942.1

3D structure databases

SMRiQ55EZ4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0234074

Proteomic databases

PaxDbiQ55EZ4

Genome annotation databases

EnsemblProtistsiEAL72942; EAL72942; DDB_G0268706
KEGGiddi:DDB_G0268706

Organism-specific databases

dictyBaseiDDB_G0268706, ints3

Phylogenomic databases

eggNOGiKOG4262, Eukaryota
HOGENOMiCLU_247789_0_0_1
InParanoidiQ55EZ4
KOiK13140
OMAiLWRDINT

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q55EZ4

Family and domain databases

InterProiView protein in InterPro
IPR019333, Int_cplx_su3
PANTHERiPTHR13587, PTHR13587, 1 hit
PfamiView protein in Pfam
PF10189, Ints3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINT3_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q55EZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 24, 2005
Last modified: October 7, 2020
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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