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Entry version 120 (07 Oct 2020)
Sequence version 1 (24 May 2005)
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Protein

Probable polyketide synthase 1

Gene

stlA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable polyketide synthase (By similarity). Produces only acylpyrones; in vitro.By similarity1 Publication

Miscellaneous

In reference to their hybrid nature and to their discovery in D.discoideum, authors term these type I FAS-type III PKS fusion enzymes 'steely'.1 Publication
Encoded by one of the numerous copies of polyketide synthase genes localized in chromosome 1.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei180For beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei682For acyl/malonyl transferase activityPROSITE-ProRule annotation1
Active sitei2930PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-163765, ChREBP activates metabolic gene expression
R-DDI-199220, Vitamin B5 (pantothenate) metabolism
R-DDI-75105, Fatty acyl-CoA biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00154

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable polyketide synthase 1
Short name:
dipks1
Including the following 2 domains:
Polyketide synthase stlA (EC:2.3.1.-)
Chalcone synthase stlA (EC:2.3.1.74)
Alternative name(s):
Steely1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:stlA
Synonyms:pks1
ORF Names:DDB_G0269364
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0269364, stlA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003779011 – 3147Probable polyketide synthase 1Add BLAST3147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2605O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q55E72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during development. Expressed maximally in early development before cellular aggregation.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0234164

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q55E72

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q55E72

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2568 – 2645CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni161 – 214Beta-ketoacyl synthaseAdd BLAST54
Regioni672 – 705Acyl/malonyl transferaseAdd BLAST34
Regioni2789 – 3147Chalcone synthaseAdd BLAST359

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi355 – 362Poly-Asp8
Compositional biasi470 – 478Poly-Asn9
Compositional biasi561 – 564Poly-Ser4
Compositional biasi576 – 581Poly-Thr6
Compositional biasi1684 – 1688Poly-Ser5
Compositional biasi2097 – 2100Poly-Gln4
Compositional biasi2647 – 2655Poly-Asn9
Compositional biasi2770 – 2774Poly-Gln5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Modular protein possessing six classical catalytic domains and a type III polyketide synthase domain. May facilitate covalent transfer of steely N-terminal acyl products directly to the C-terminal type III PKS active sites, which catalyze both iterative polyketide extension and cyclization.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1202, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_31_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q55E72

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSPKIDF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q55E72

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR012328, Chalcone/stilbene_synth_C
IPR001099, Chalcone/stilbene_synthase_N
IPR011032, GroES-like_sf
IPR032821, KAsynt_C_assoc
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR013217, Methyltransf_12
IPR036291, NAD(P)-bd_dom_sf
IPR020801, PKS_acyl_transferase
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR009081, PP-bd_ACP
IPR029063, SAM-dependent_MTases
IPR016039, Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF02797, Chal_sti_synt_C, 1 hit
PF00195, Chal_sti_synt_N, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF08242, Methyltransf_12, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827, PKS_AT, 1 hit
SM00829, PKS_ER, 1 hit
SM00825, PKS_KS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53335, SSF53335, 1 hit
SSF53901, SSF53901, 3 hits
SSF55048, SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit
PS00012, PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q55E72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKNSKIQSP NSSDVAVIGV GFRFPGNSND PESLWNNLLD GFDAITQVPK
60 70 80 90 100
ERWATSFREM GLIKNKFGGF LKDSEWKNFD PLFFGIGPKE APFIDPQQRL
110 120 130 140 150
LLSIVWESLE DAYIRPDELR GSNTGVFIGV SNNDYTKLGF QDNYSISPYT
160 170 180 190 200
MTGSNSSLNS NRISYCFDFR GPSITVDTAC SSSLVSVNLG VQSIQMGECK
210 220 230 240 250
IAICGGVNAL FDPSTSVAFS KLGVLSENGR CNSFSDQASG YVRSEGAGVV
260 270 280 290 300
VLKSLEQAKL DGDRIYGVIK GVSSNEDGAS NGDKNSLTTP SCEAQSINIS
310 320 330 340 350
KAMEKASLSP SDIYYIEAHG TGTPVGDPIE VKALSKIFSN SNNNQLNNFS
360 370 380 390 400
TDGNDNDDDD DDNTSPEPLL IGSFKSNIGH LESAAGIASL IKCCLMLKNR
410 420 430 440 450
MLVPSINCSN LNPSIPFDQY NISVIREIRQ FPTDKLVNIG INSFGFGGSN
460 470 480 490 500
CHLIIQEYNN NFKNNSTICN NNNNNNNNID YLIPISSKTK KSLDKYLILI
510 520 530 540 550
KTNSNYHKDI SFDDFVKFQI KSKQYNLSNR MTTIANDWNS FIKGSNEFHN
560 570 580 590 600
LIESKDGEGG SSSSNRGIDS ANQINTTTTS TINDIEPLLV FVFCGQGPQW
610 620 630 640 650
NGMIKTLYNS ENVFKNTVDH VDSILYKYFG YSILNVLSKI DDNDDSINHP
660 670 680 690 700
IVAQPSLFLL QIGLVELFKY WGIYPSISVG HSFGEVSSYY LSGIISLETA
710 720 730 740 750
CKIVYVRSSN QNKTMGSGKM LVVSMGFKQW NDQFSAEWSD IEIACYNAPD
760 770 780 790 800
SIVVTGNEER LKELSIKLSD ESNQIFNTFL RSPCSFHSSH QEVIKGSMFE
810 820 830 840 850
ELSNLQSTGE TEIPLFSTVT GRQVLSGHVT AQHIYDNVRE PVLFQKTIES
860 870 880 890 900
ITSYIKSHYP SNQKVIYVEI APHPTLFSLI KKSIPSSNKN SSSVLCPLNR
910 920 930 940 950
KENSNNSYKK FVSQLYFNGV NVDFNFQLNS ICDNVNNDHH LNNVKQNSFK
960 970 980 990 1000
ETTNSLPRYQ WEQDEYWSEP LISRKNRLEG PTTSLLGHRI IYSFPVFQSV
1010 1020 1030 1040 1050
LDLQSDNYKY LLDHLVNGKP VFPGAGYLDI IIEFFDYQKQ QLNSSDSSNS
1060 1070 1080 1090 1100
YIINVDKIQF LNPIHLTENK LQTLQSSFEP IVTKKSAFSV NFFIKDTVED
1110 1120 1130 1140 1150
QSKVKSMSDE TWTNTCKATI SLEQQQPSPS STLTLSKKQD LQILRNRCDI
1160 1170 1180 1190 1200
SKLDKFELYD KISKNLGLQY NSLFQVVDTI ETGKDCSFAT LSLPEDTLFT
1210 1220 1230 1240 1250
TILNPCLLDN CFHGLLTLIN EKGSFVVESI SSVSIYLENI GSFNQTSVGN
1260 1270 1280 1290 1300
VQFYLYTTIS KATSFSSEGT CKLFTKDGSL ILSIGKFIIK STNPKSTKTN
1310 1320 1330 1340 1350
ETIESPLDET FSIEWQSKDS PIPTPQQIQQ QSPLNSNPSF IRSTILKDIQ
1360 1370 1380 1390 1400
FEQYCSSIIH KELINHEKYK NQQSFDINSL ENHLNDDQLM ESLSISKEYL
1410 1420 1430 1440 1450
RFFTRIISII KQYPKILNEK ELKELKEIIE LKYPSEVQLL EFEVIEKVSM
1460 1470 1480 1490 1500
IIPKLLFEND KQSSMTLFQD NLLTRFYSNS NSTRFYLERV SEMVLESIRP
1510 1520 1530 1540 1550
IVREKRVFRI LEIGAGTGSL SNVVLTKLNT YLSTLNSNGG SGYNIIIEYT
1560 1570 1580 1590 1600
FTDISANFII GEIQETMCNL YPNVTFKFSV LDLEKEIINS SDFLMGDYDI
1610 1620 1630 1640 1650
VLMAYVIHAV SNIKFSIEQL YKLLSPRGWL LCIEPKSNVV FSDLVFGCFN
1660 1670 1680 1690 1700
QWWNYYDDIR TTHCSLSESQ WNQLLLNQSL NNESSSSSNC YGGFSNVSFI
1710 1720 1730 1740 1750
GGEKDVDSHS FILHCQKESI SQMKLATTIN NGLSSGSIVI VLNSQQLTNM
1760 1770 1780 1790 1800
KSYPKVIEYI QEATSLCKTI EIIDSKDVLN STNSVLEKIQ KSLLVFCLLG
1810 1820 1830 1840 1850
YDLLENNYQE QSFEYVKLLN LISTTASSSN DKKPPKVLLI TKQSERISRS
1860 1870 1880 1890 1900
FYSRSLIGIS RTSMNEYPNL SITSIDLDTN DYSLQSLLKP IFSNSKFSDN
1910 1920 1930 1940 1950
EFIFKKGLMF VSRIFKNKQL LESSNAFETD SSNLYCKASS DLSYKYAIKQ
1960 1970 1980 1990 2000
SMLTENQIEI KVECVGINFK DNLFYKGLLP QEIFRMGDIY NPPYGLECSG
2010 2020 2030 2040 2050
VITRIGSNVT EYSVGQNVFG FARHSLGSHV VTNKDLVILK PDTISFSEAA
2060 2070 2080 2090 2100
SIPVVYCTAW YSLFNIGQLS NEESILIHSA TGGVGLASLN LLKMKNQQQQ
2110 2120 2130 2140 2150
PLTNVYATVG SNEKKKFLID NFNNLFKEDG ENIFSTRDKE YSNQLESKID
2160 2170 2180 2190 2200
VILNTLSGEF VESNFKSLRS FGRLIDLSAT HVYANQQIGL GNFKFDHLYS
2210 2220 2230 2240 2250
AVDLERLIDE KPKLLQSILQ RITNSIVNGS LEKIPITIFP STETKDAIEL
2260 2270 2280 2290 2300
LSKRSHIGKV VVDCTDISKC NPVGDVITNF SMRLPKPNYQ LNLNSTLLIT
2310 2320 2330 2340 2350
GQSGLSIPLL NWLLSKSGGN VKNVVIISKS TMKWKLQTMI SHFVSGFGIH
2360 2370 2380 2390 2400
FNYVQVDISN YDALSEAIKQ LPSDLPPITS VFHLAAIYND VPMDQVTMST
2410 2420 2430 2440 2450
VESVHNPKVL GAVNLHRISV SFGWKLNHFV LFSSITAITG YPDQSIYNSA
2460 2470 2480 2490 2500
NSILDALSNF RRFMGLPSFS INLGPMKDEG KVSTNKSIKK LFKSRGLPSL
2510 2520 2530 2540 2550
SLNKLFGLLE VVINNPSNHV IPSQLICSPI DFKTYIESFS TMRPKLLHLQ
2560 2570 2580 2590 2600
PTISKQQSSI INDSTKASSN ISLQDKITSK VSDLLSIPIS KINFDHPLKH
2610 2620 2630 2640 2650
YGLDSLLTVQ FKSWIDKEFE KNLFTHIQLA TISINSFLEK VNGLSTNNNN
2660 2670 2680 2690 2700
NNNSNVKSSP SIVKEEIVTL DKDQQPLLLK EHQHIIISPD IRINKPKRES
2710 2720 2730 2740 2750
LIRTPILNKF NQITESIITP STPSLSQSDV LKTPPIKSLN NTKNSSLINT
2760 2770 2780 2790 2800
PPIQSVQQHQ KQQQKVQVIQ QQQQPLSRLS YKSNNNSFVL GIGISVPGEP
2810 2820 2830 2840 2850
ISQQSLKDSI SNDFSDKAET NEKVKRIFEQ SQIKTRHLVR DYTKPENSIK
2860 2870 2880 2890 2900
FRHLETITDV NNQFKKVVPD LAQQACLRAL KDWGGDKGDI THIVSVTSTG
2910 2920 2930 2940 2950
IIIPDVNFKL IDLLGLNKDV ERVSLNLMGC LAGLSSLRTA ASLAKASPRN
2960 2970 2980 2990 3000
RILVVCTEVC SLHFSNTDGG DQMVASSIFA DGSAAYIIGC NPRIEETPLY
3010 3020 3030 3040 3050
EVMCSINRSF PNTENAMVWD LEKEGWNLGL DASIPIVIGS GIEAFVDTLL
3060 3070 3080 3090 3100
DKAKLQTSTA ISAKDCEFLI HTGGKSILMN IENSLGIDPK QTKNTWDVYH
3110 3120 3130 3140
AYGNMSSASV IFVMDHARKS KSLPTYSISL AFGPGLAFEG CFLKNVV
Length:3,147
Mass (Da):352,195
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B67391AB6596F46
GO

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72032.1

Genome annotation databases

Ensembl protists genome annotation project

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EnsemblProtistsi
EAL72032; EAL72032; DDB_G0269364

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ddi:DDB_G0269364

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72032.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H84X-ray2.90A/B2776-3147[»]
SMRiQ55E72
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0234164

Proteomic databases

PaxDbiQ55E72

Genome annotation databases

EnsemblProtistsiEAL72032; EAL72032; DDB_G0269364
KEGGiddi:DDB_G0269364

Organism-specific databases

dictyBaseiDDB_G0269364, stlA

Phylogenomic databases

eggNOGiKOG1202, Eukaryota
HOGENOMiCLU_000022_31_5_1
InParanoidiQ55E72
OMAiPSPKIDF
PhylomeDBiQ55E72

Enzyme and pathway databases

UniPathwayiUPA00154
ReactomeiR-DDI-163765, ChREBP activates metabolic gene expression
R-DDI-199220, Vitamin B5 (pantothenate) metabolism
R-DDI-75105, Fatty acyl-CoA biosynthesis

Miscellaneous databases

EvolutionaryTraceiQ55E72

Protein Ontology

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PROi
PR:Q55E72

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 3 hits
InterProiView protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR012328, Chalcone/stilbene_synth_C
IPR001099, Chalcone/stilbene_synthase_N
IPR011032, GroES-like_sf
IPR032821, KAsynt_C_assoc
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR013217, Methyltransf_12
IPR036291, NAD(P)-bd_dom_sf
IPR020801, PKS_acyl_transferase
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR009081, PP-bd_ACP
IPR029063, SAM-dependent_MTases
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF02797, Chal_sti_synt_C, 1 hit
PF00195, Chal_sti_synt_N, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF08242, Methyltransf_12, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
SMARTiView protein in SMART
SM00827, PKS_AT, 1 hit
SM00829, PKS_ER, 1 hit
SM00825, PKS_KS, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53335, SSF53335, 1 hit
SSF53901, SSF53901, 3 hits
SSF55048, SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit
PS00012, PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKS1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q55E72
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 24, 2005
Last modified: October 7, 2020
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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