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Entry version 80 (03 Jul 2019)
Sequence version 1 (24 May 2005)
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Protein

Mental retardation GTPase activating protein homolog 3

Gene

mgp3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rho GTPase-activating protein involved in the signal transduction pathway.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mental retardation GTPase activating protein homolog 3
Alternative name(s):
GTPase activating factor for raC protein AA
Rho GTPase-activating protein gacAA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mgp3
Synonyms:gacAA
ORF Names:DDB_G0269624
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0269624 mgp3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003802261 – 1337Mental retardation GTPase activating protein homolog 3Add BLAST1337

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q55DK5

PRoteomics IDEntifications database

More...
PRIDEi
Q55DK5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0233874

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q55DK5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 264F-BARPROSITE-ProRule annotationAdd BLAST251
Domaini422 – 611Rho-GAPPROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili830 – 859Sequence analysisAdd BLAST30
Coiled coili1189 – 1219Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi294 – 300Poly-Pro7
Compositional biasi319 – 324Poly-Ser6
Compositional biasi621 – 629Poly-Ser9
Compositional biasi665 – 675Poly-GlnAdd BLAST11
Compositional biasi734 – 749Poly-AsnAdd BLAST16
Compositional biasi1086 – 1096Poly-AsnAdd BLAST11
Compositional biasi1120 – 1132Poly-AsnAdd BLAST13
Compositional biasi1144 – 1158Poly-ThrAdd BLAST15
Compositional biasi1322 – 1336Poly-AsnAdd BLAST15

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG4K Eukaryota
ENOG410XQ23 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q55DK5

Identification of Orthologs from Complete Genome Data

More...
OMAi
YLCYLGG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00611 FCH, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00055 FCH, 1 hit
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51741 F_BAR, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q55DK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVDNSQIPN LNQPESFADL WDGYENVSKA TEKGVLLLKD ITKFFKKRIQ
60 70 80 90 100
SEDEYSKTLS KLVLKFEPMA PDGYIGPRLK NTWDQIKLET LTHSNHHENI
110 120 130 140 150
CNNISTHIIE PIEGLIVDLE QKMKSIHVDA EKSFIHYQES VAKLKKAKQN
160 170 180 190 200
YDRLCKDSFE ITGVSKGETQ KVQKRAIKAA QDVIKADKDY RAQINETNTS
210 220 230 240 250
QKQFLTELIP KIMNDLQRLE MVRIHMVKSY FHRYFKSMES TPQKFNTETE
260 270 280 290 300
NLLNLINSIN NEDEIQDFVR KSKTTHKYPK PFEYEPYLDR FTTPPPPPPP
310 320 330 340 350
QISSPQLLSP RGDISIQHSS SSNSLPIFPT QHQLLSNKEK ADNNITNSLS
360 370 380 390 400
LSSDSLQTNL NNGNNGGNGN NGSNTPTKEK KPSSWGLKRF STSVSSTSDR
410 420 430 440 450
KLLNKQIQSI GLAHNGGNIF NCKIEDIMVA QKKKYPYLEI PFIVVFLKHK
460 470 480 490 500
LVALDVFKTQ GIFRVPGNVV DINSLKKRFD EGNYEVAPTE NVYTIASLLK
510 520 530 540 550
LWLREITEPL FPLTVYDQCI ENSNKREKIF EIISSLPILN QKTISYIIEL
560 570 580 590 600
LQECGKSVNV EHNKMNFPNL AMVFSPCFLR CSHTDPNILL GNIFKEKEFV
610 620 630 640 650
QNIIEHFKPL QVNDSLEGPP SSSSSSSTSI NQSSIESPPT SPLRSSTNSN
660 670 680 690 700
ANKSSTPIKP SSPSQQQQQQ QQQQQSSTPS TPLSSTTNTN VKHNILSPIV
710 720 730 740 750
EQQSPNNGKQ PIALTQTYSH LNIGSVPLII NTVNNNNQNQ NQNQNQNQNQ
760 770 780 790 800
DQNQNQSKQP IQSSNQTQQQ VSAPATPHTV AVNPKINQIK AETITTPQKS
810 820 830 840 850
IGDGNGLIGQ SPSAHLMSPS EVKRRSNAIY LEDQERCKQR IDELHTQVNE
860 870 880 890 900
LYSDITTIET TTYFAMQSSL LITKLTKSLE SFLTIDMWNL TLQDIKEAIE
910 920 930 940 950
KNKFVSPPPI NFKIPSKMPK LSPIELVQNE QSSELLRSWL SNVTLTVNRI
960 970 980 990 1000
NEYLCYLGGV VIRIHSPDTL FAISNLFTDY DLSPQQNPKF VSLTLEQSTI
1010 1020 1030 1040 1050
FIQKTLALLE PLNPFTSDEL NINVKVQDTI TPASFSPALI SDPDCNSPPT
1060 1070 1080 1090 1100
ISNTTNRLLN TSGSTDFSTT PLSSSPSTSS TSLSTNNNNN NNGNRNLDIN
1110 1120 1130 1140 1150
NSPTIVITNS SLNKSALSTN NNNNNNNNNN NNPTTKLSSS TSSTSTTTTT
1160 1170 1180 1190 1200
NTNTNTTTNE KIAHAIISPS SSTTSFKFDD DEDEDEDLLE INNKLHSQLT
1210 1220 1230 1240 1250
EELKKKQQQY KQLIFDIIDM IKDKKKLMNS LDLTNSDSQL DIKSIAKLSL
1260 1270 1280 1290 1300
SLKRALDNFT SESGFDIEDE QDPIINKEND SFVNLKIMTS HFISRIVLIL
1310 1320 1330
TTILSISNEF NSTLYQLLLP FNENNNNNNE NNNINNQ
Length:1,337
Mass (Da):150,248
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73393E0FD5FD8AF4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72162.1

NCBI Reference Sequences

More...
RefSeqi
XP_646126.1, XM_641034.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL72162; EAL72162; DDB_G0269624

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8617075

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0269624

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72162.1
RefSeqiXP_646126.1, XM_641034.1

3D structure databases

SMRiQ55DK5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0233874

Proteomic databases

PaxDbiQ55DK5
PRIDEiQ55DK5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL72162; EAL72162; DDB_G0269624
GeneIDi8617075
KEGGiddi:DDB_G0269624

Organism-specific databases

dictyBaseiDDB_G0269624 mgp3

Phylogenomic databases

eggNOGiENOG410IG4K Eukaryota
ENOG410XQ23 LUCA
InParanoidiQ55DK5
OMAiYLCYLGG

Enzyme and pathway databases

ReactomeiR-DDI-194840 Rho GTPase cycle

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q55DK5

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGP3_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q55DK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 24, 2005
Last modified: July 3, 2019
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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