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Entry version 86 (16 Jan 2019)
Sequence version 1 (24 May 2005)
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Protein

Probable serine/threonine-protein kinase irlC

Gene

irlC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1010ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1116Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri495 – 529SWIM-typePROSITE-ProRule annotationAdd BLAST35
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi987 – 995ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable serine/threonine-protein kinase irlC (EC:2.7.11.1)
Alternative name(s):
Inositol-requiring protein-like protein kinase C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:irlC
ORF Names:DDB_G0270894
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0270894 irlC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003620181 – 1444Probable serine/threonine-protein kinase irlCAdd BLAST1444

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q55DJ8

PRoteomics IDEntifications database

More...
PRIDEi
Q55DJ8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0231222

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q55DJ8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini981 – 1246Protein kinasePROSITE-ProRule annotationAdd BLAST266
Domaini1279 – 1444KENPROSITE-ProRule annotationAdd BLAST166

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili593 – 620Sequence analysisAdd BLAST28
Coiled coili847 – 879Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi241 – 248Poly-Gln8
Compositional biasi338 – 368Poly-AsnAdd BLAST31
Compositional biasi432 – 438Poly-Gln7
Compositional biasi591 – 616Poly-AsnAdd BLAST26
Compositional biasi861 – 878Lys-richAdd BLAST18
Compositional biasi885 – 897Poly-SerAdd BLAST13
Compositional biasi899 – 927Poly-ThrAdd BLAST29
Compositional biasi954 – 957Poly-Pro4
Compositional biasi1291 – 1294Poly-Ser4
Compositional biasi1295 – 1303Poly-Asn9
Compositional biasi1306 – 1313Poly-Asn8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri495 – 529SWIM-typePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1027 Eukaryota
COG0515 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q55DJ8

Identification of Orthologs from Complete Genome Data

More...
OMAi
FAISEEC

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1440.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010513 KEN_dom
IPR038357 KEN_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR007527 Znf_SWIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit
PF06479 Ribonuc_2-5A, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51392 KEN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50966 ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q55DJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSNYSTYLY KMSELERIVN GGDVSSIFIE QDDVLGEIKN FNYDLYTKYD
60 70 80 90 100
SLVLKDPQTQ NNSPKPPSLE IFILVNLIAL CGRINDKFPN LDKFLTHYKY
110 120 130 140 150
ATNIFNLLSE NIINSIEKFK ETLSKDLPSF QLSVIANSSI VKKDNSIIKF
160 170 180 190 200
LSCFGSFMKL ESIEYFGSVF NSLIGEEDQF SLDLLQVLID SSNEYKKFLQ
210 220 230 240 250
ILEFNQLQKY YDDGHLCLFH SIKFDNLNEF KLLFNDSTWC QQQQQQQQIN
260 270 280 290 300
PQIFWFILCK YNSSKIAHYL LNDYQINKKS LKQKNPLEIS PVTLLEIAFL
310 320 330 340 350
CFSDKIAIVL FSQFNYHELL PKKSKMKHLI KSTSTLINNN NNNNNNNNNN
360 370 380 390 400
NNNNNNNNNN NNNNNNNNSK NIGLTQYTVL EGYFLINIRT RSRIAPFIEV
410 420 430 440 450
LTMNGIHLTN DIIHTRIKSM SSDSIFRIFT EQYQQQQQNP LNNNQKQIQF
460 470 480 490 500
NENFTRQQKI DFDNCPNEID TFILDKTQCN LITLSQEFSI KVRAFTFYLS
510 520 530 540 550
FGEIFTCSCE DYKREFSCKH MFFILLNYYH VPRNSYLIYQ RQFTEIERYS
560 570 580 590 600
IIMNIDLSKI NSRIYGTPNF NTFFKIKSSP SSTTSPFQSI NNNNNNNLNN
610 620 630 640 650
NNNNNLNNNN NNENENKFKE DGDDEILQNL NRLNYILLRD FEFGPNDITT
660 670 680 690 700
KLRETHINLF DRLLLIEDNL EALDKILKNF TQKGCTLSRD LVGDRNLLVL
710 720 730 740 750
VAILDSTSKE KLSLLNKYWP LPEKTKKFAI PLIFFAISEE CLKMFIQISP
760 770 780 790 800
NLVKSTLNLH DWISILTEFA LINETFLDHY PLLSAWYSDA RSVETSLFRL
810 820 830 840 850
FTCMDKIDCI NYLIQTYLLP IPTFKNTLNN FETCYFFETY FLENSSIKAE
860 870 880 890 900
QYLLEQELLE KKKQKEKKKQ KQKQSKSKII NNPLSSSSSS SSSPSTSNTT
910 920 930 940 950
ITSTTPTTTT TTTTTTTPTT TTTTTTTSSP KQKPITPIKK EIEKEFEKIE
960 970 980 990 1000
LTTPPPPLAT TKQQQINENY DISIGKFKFN RKEENVLGRG SNGTLVFKGI
1010 1020 1030 1040 1050
WNNRIPVAIK QMQKMFNPLI SKEIEVLITL TNKNCYNIVR YIDQEEDESC
1060 1070 1080 1090 1100
VYLGLTLCDG SLQNLVEKGD NNLTLTQFLG YDINSSSKNN SRLLELIKDI
1110 1120 1130 1140 1150
VYGIQFLHQQ GIVHNDLNPR NILIKDDRFI ISDLGLSKME VTSSYSFTMH
1160 1170 1180 1190 1200
APTGQEGFHP AEVLLEKRKT KSVDIFSMGC ILFYLMTGGQ HPFGDKFYRI
1210 1220 1230 1240 1250
VNILTDKPIL EPLKHNLVAC DLISQMISKN ESDRPTIEKI LLHPFFWNHE
1260 1270 1280 1290 1300
KKVKFIDASL NLFKDSNGLF TSKLNKLINY QEINLKNNID SSSSNNNNNI
1310 1320 1330 1340 1350
NSNVINNNNN NNNGMATNIP FLSKPWNQLI DQTLIEHIIN KQNQLNGVGN
1360 1370 1380 1390 1400
NKKVIIYSFD QVKDLVRCIR NTIQHHKEIQ RLVRQSPSSN GDNKQEVLDC
1410 1420 1430 1440
LESQELVLSY FEEKVPDLLL FLYQKFKKHL DSKSLIYFND LIIK
Length:1,444
Mass (Da):167,425
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD37E930910AF1CAC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72797.1

NCBI Reference Sequences

More...
RefSeqi
XP_646133.1, XM_641041.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL72797; EAL72797; DDB_G0270894

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8617083

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0270894

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72797.1
RefSeqiXP_646133.1, XM_641041.1

3D structure databases

SMRiQ55DJ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231222

Proteomic databases

PaxDbiQ55DJ8
PRIDEiQ55DJ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL72797; EAL72797; DDB_G0270894
GeneIDi8617083
KEGGiddi:DDB_G0270894

Organism-specific databases

dictyBaseiDDB_G0270894 irlC

Phylogenomic databases

eggNOGiKOG1027 Eukaryota
COG0515 LUCA
InParanoidiQ55DJ8
OMAiFAISEEC

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q55DJ8

Family and domain databases

Gene3Di1.20.1440.180, 1 hit
InterProiView protein in InterPro
IPR010513 KEN_dom
IPR038357 KEN_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR007527 Znf_SWIM
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF06479 Ribonuc_2-5A, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51392 KEN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50966 ZF_SWIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRLC_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q55DJ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: January 16, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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