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Protein

Probable serine/threonine-protein kinase gdt8

Gene

gdt8

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1065ATPPROSITE-ProRule annotation1
Active sitei1158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1042 – 1050ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase gdt8 (EC:2.7.11.1)
Alternative name(s):
Growth-differentiation transition protein 8
Gene namesi
Name:gdt8
ORF Names:DDB_G0270668
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270668 gdt8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 782ExtracellularSequence analysisAdd BLAST760
Transmembranei783 – 803HelicalSequence analysisAdd BLAST21
Topological domaini804 – 1326CytoplasmicSequence analysisAdd BLAST523

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000032358523 – 1326Probable serine/threonine-protein kinase gdt8Add BLAST1304

Proteomic databases

PaxDbiQ55CY9

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0220636

Structurei

3D structure databases

ProteinModelPortaliQ55CY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1036 – 1292Protein kinasePROSITE-ProRule annotationAdd BLAST257

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi422 – 593Asn-richAdd BLAST172
Compositional biasi712 – 769Thr-richAdd BLAST58

Sequence similaritiesi

In the N-terminal section; belongs to the GDT family.Curated
In the C-terminal section; belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
InParanoidiQ55CY9
PhylomeDBiQ55CY9

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR026237 STKINASEGDT
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR02079 STKINASEGDT
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55CY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MINKILIKLI TIIIFCFSFL FAEEDLIRTP PGYYNLTRHK RYPHITEYQS
60 70 80 90 100
SQDTDLYYPD VCRNALRNDI IPGVDEFFPF LFPGFNSDGP NSIYIQKNSS
110 120 130 140 150
LLFKSESLGT TYNFVAVCVE GSFTVKGSMF FTINSLIILP GGRFESEAGI
160 170 180 190 200
EFYDENDPLH IYNNPDFPKD PFGFFPGILV LGGTISVVAK ESLVYRADRI
210 220 230 240 250
SNSSIEISPP FSPMNKINQT IRIFTELYPL GFYCSFSSDL ERKILSLLDC
260 270 280 290 300
LPISENDKII RVLIEVDRDQ NVSPTNILKK GKTTKGSIYI TGDSNVYFKN
310 320 330 340 350
MFFKNLGFTT NEPYNDTKLI FSPNDPNQVT DIIMGTNQRF RSSLYIEFSK
360 370 380 390 400
NVTIDGCAFF EDNLTRSPLV LFDSNVIISN SLISSKSGSN IIAQYGTESI
410 420 430 440 450
QSSNNSYILV KIDTASLDVD QNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
460 470 480 490 500
NNNNNNNNNN MDYGNQGNGI YSISPNINSN GDSFFGQQYA FNYYFISKNS
510 520 530 540 550
VNSNQDNSSL LNSKPIELII IDSSFNPTNS NGSLNKYLLN INSDGNKTIS
560 570 580 590 600
TYLVCNSIIE YYSGWLMDNL NSNQQISFEG NLFQNGCNKV DGNCTISQNS
610 620 630 640 650
KYSTDLPKVA NQTKFDEIVQ LDKLFSNGIT SINPNEKVII STKINSKIHY
660 670 680 690 700
YQIQLFFTHL PIDDQPTPLS IYIENQPVFL LEPIKSTFPT FNNFTFKFEN
710 720 730 740 750
KNSLDKINIA FTTRGDIYLT SMATYSSIVV EPPTETPTET PTETPTETPT
760 770 780 790 800
DTPTQTPTQT PILTSKPITQ ISVDRNENLE LKIALPICLS LALLIGIIIM
810 820 830 840 850
ICIFKKVQSN SKLKKDDDEN EMATIKEGNK SIIVSQPPTV IEEKPQDNSK
860 870 880 890 900
PDDQKLIERD QQINNPILKI REYPSLKDIE LSNEETKSPQ YGSLNSFSTL
910 920 930 940 950
QFSRQYDYGS EEFPFQFNKQ VLEFNLNGRK CMNDEVINDS LMIHNKSEIT
960 970 980 990 1000
YLVNIIFPQN IETGCVSILN VEIFNESFEL LPHCTTEVKF SLTLTCTTKF
1010 1020 1030 1040 1050
LENFAVLVEA QGSKCHTFLS VHVESETSLK LDYKEIKTEQ LIASYLPSKV
1060 1070 1080 1090 1100
YVFKGYYRDL AVAVKKFAIS DNSKSFEKIK NEVQILSKVN NINVVRYIGS
1110 1120 1130 1140 1150
AQNISHVCIV TEYAKEGSLG SLIHDSKIKL SFIQKVKFML DAAKGFTFLH
1160 1170 1180 1190 1200
ASEIVHGDIK PDNLLVFSKE ISGVCVKICD FGNSEELGEK ESKSKPDSTM
1210 1220 1230 1240 1250
NYLPNEVFDG EGYQKSADVY AFGVSLYEVM VEKIPFHEIC YNDIPNRVQD
1260 1270 1280 1290 1300
GFRPTADLDT IDDDIRKIIE CCWIKEKSKR PSFSEISLHL EIKFSKLLHQ
1310 1320
MNESEESTSN HNTNSKTKED KDLDEN
Length:1,326
Mass (Da):150,109
Last modified:May 24, 2005 - v1
Checksum:iC8F07D060C277261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72684.1
RefSeqiXP_646342.1, XM_641250.1

Genome annotation databases

EnsemblProtistsiEAL72684; EAL72684; DDB_G0270668
GeneIDi8617297
KEGGiddi:DDB_G0270668

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72684.1
RefSeqiXP_646342.1, XM_641250.1

3D structure databases

ProteinModelPortaliQ55CY9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0220636

Proteomic databases

PaxDbiQ55CY9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL72684; EAL72684; DDB_G0270668
GeneIDi8617297
KEGGiddi:DDB_G0270668

Organism-specific databases

dictyBaseiDDB_G0270668 gdt8

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
InParanoidiQ55CY9
PhylomeDBiQ55CY9

Miscellaneous databases

PROiPR:Q55CY9

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR026237 STKINASEGDT
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR02079 STKINASEGDT
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGDT8_DICDI
AccessioniPrimary (citable) accession number: Q55CY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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Main funding by: National Institutes of Health

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