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UniProtKB - Q55CN6 (PKS3_DICDI)
Protein
Probable polyketide synthase 3
Gene
pks3
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes localized in chromosome 1.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 209 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 674 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks3 ORF Names:DDB_G0271000 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0271000, pks3 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2464 – 2484 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000376879 | 1 – 2837 | Probable polyketide synthase 3Add BLAST | 2837 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2367 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | Q55CN6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2330 – 2407 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 190 – 243 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 664 – 697 | Acyl/malonyl transferaseAdd BLAST | 34 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1178, Eukaryota KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | Q55CN6 |
PhylomeDBi | Q55CN6 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF07993, NAD_binding_4, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q55CN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVSAYLPTC LPTYLPTCLP TYLPTYLPTY LPICLSEENN GIGIIGIGFR
60 70 80 90 100
LPGGGSGKSL GNPSELWKEL VNGYDGIIET NERWSDNFNK LGEINNRYGG
110 120 130 140 150
LLPMDEVKSF DPLFFGISPP EATAIDPQQR LLLKCTWEAI EDAMIDPINL
160 170 180 190 200
RGSNTSVFIG NTTHEYRDLN RTIDSIQTNI FSSSSHSSSN RVSNIFDFHG
210 220 230 240 250
PSITIDTACS SSSNAVVLGC KSIIEGNSKM SIVGGTSLIF DANTPKSFSY
260 270 280 290 300
MNMLSKDGRC KSFDANADGY VKSECIGVLL LKDLNQAIID GDRVYCVIKG
310 320 330 340 350
TSSNVDGNGY SDKSNFYSPS AQSQAENIKM ALSSGNINAK DVDYVEAHGT
360 370 380 390 400
GTPVGDPIEV EGISSIFKDN HSKENPLLIG SFKSMIGHCE ASSGIASLVK
410 420 430 440 450
CCLMFKNRYF IPNLHFKTPN PLIKFNEWNL KVVVEPTPFP KKEITMAVNN
460 470 480 490 500
FGVTGSNVCI ILKDFNYNHN SSSDNNNTIN LKQQQHQNNI EYLIPFSANS
510 520 530 540 550
TKSLEQYQSL ISNFNQETME FNDFVKEQIM SKSNSLYQRS VILGSNWNDF
560 570 580 590 600
KDNLISTNNN IKTIKTTSSN ISIKSKNPII IMVFCGQGSQ YNTMALELYK
610 620 630 640 650
NEPIFRKTMD MLDNKLSKYY GFSILEKLRS IPVDDMKSIH NPALAQPAIC
660 670 680 690 700
MVQISLFELY KHWGIKPTFI VGHSLGEVTA AYCSGMIDLE TECYLIYHRS
710 720 730 740 750
IAQSTTTGCG RMLSINISPE KFIEQFSSRY PDVEISCYNS PTSIVIGGKE
760 770 780 790 800
DQLNKISEEL KSKGEFTSML GSLSSFHTSS QKAIKEYILS LDYKSKESEI
810 820 830 840 850
PIFSTVTTNL FDYKTTPYSP KYTYENILKS VNFTQTIENL YKHIENNQLG
860 870 880 890 900
TDIVFIELAP HPTLQFYLKQ MIPKDSSYFG KGDSISIYSP LHKKKNDVKE
910 920 930 940 950
IRQTISQLYC QNGYNINFKC QFENINRSIV PTHKLPLYQW DEKQFWKINS
960 970 980 990 1000
LYENYYLTGP PIDILGNSIT DSPFVKSYQT FINIKRKPFQ YLKGHVVKGK
1010 1020 1030 1040 1050
FYFPGCGYID NLLKIYPSQD ITISTLEFST PFIFTDDSVN HCLQTNIYPT
1060 1070 1080 1090 1100
GKTEYKVLFH FKDQKKNEWI QSSFGNFQLF KHNGEKSLKI FNQKYNIKDL
1110 1120 1130 1140 1150
IEKRCNLTKL TKEDLYDHIK LKTGLTYSGM FQAVSMCYLG DNCSLSVVSL
1160 1170 1180 1190 1200
ELPKHLPDQK SFFNSSILDC CLHGMIGLVD EHCQLVFDRI EGFNLYSSNI
1210 1220 1230 1240 1250
PSARDQHTNV YVYSSLNAKM GDSYFASIVV MLEDGTVLIE IDNAACTSLT
1260 1270 1280 1290 1300
PIQDSLKIEA PTNELYSTYL QSKDSLILPP QTFESLYQQE KGQNDILVGT
1310 1320 1330 1340 1350
IIKQSLVPFV NEKMVFRILD FSSGFADYNG TTFHSSNNVL EKFNQLLKEF
1360 1370 1380 1390 1400
PLCEIDIEYT FGSVPQSLTS SIKDKLSHIN ERVSILYRDY SINDPLLLED
1410 1420 1430 1440 1450
NQLKPSQYDI VLINDLEKET NDIKATLYMI YNLMVPNGQL ILINNDGNNL
1460 1470 1480 1490 1500
IEIKELLDQC NFKDTIISND KKSIIQTRKP QLLSELSPNP NIDSYDQIII
1510 1520 1530 1540 1550
YSNDDSEICN KFLKSLESTD DKILSIISTI SKFNEFVEKQ SITDKSVIYF
1560 1570 1580 1590 1600
IKTMEQLTLD NFKSITFEYI EINRKLLKLN SMCKHVLITS DSRKDNYLAS
1610 1620 1630 1640 1650
SVIGAARYFD EFQQLQLFTL DFDKESIIEY THNNNEKNLV SLIELLTDKK
1660 1670 1680 1690 1700
ISIQKEYLIR NGKVYFERIK KEQNLRKKFK SESYQDLVEN DLVAVLSPNL
1710 1720 1730 1740 1750
EYELKPMTKD LEPFEVQVEI KSFALNYKDY LTYIGSVPPE MVNHKTGDIN
1760 1770 1780 1790 1800
DPEFGSDFSG VITRVSKNNC SEFKVGDQVY GTAYNTASSK SIIDSGSIYF
1810 1820 1830 1840 1850
KPNNLSHEQA STIPVVYSTS LHSIYNIGNL KNYESILIHS ASGGVGLSSL
1860 1870 1880 1890 1900
NILKWKGHCS YIFLTVGSPE KEKYLRDTYG SLITGIYSTR DKSYVQKIKD
1910 1920 1930 1940 1950
KLKELGSDKT GVDLILNTLS SDYMDSNFNC LSKSGRIVDL SITHLNSNEY
1960 1970 1980 1990 2000
IDNKKFKFNY GYHNVELLFI AAPILKKLLK SISKAIENNE LINNLPITQY
2010 2020 2030 2040 2050
SNVNIKNAFE YINQRKHIGK IVVNHDTDLV GNLIKEKINS TSNLDFTLLK
2060 2070 2080 2090 2100
SNYQININNL GKNIIVTGQS GIVFEIIKWI VKFAPLVENI IILSKSSMKW
2110 2120 2130 2140 2150
QLELLVNRNK HIKFHFKSVD VGDINSMGKA IDEVSNDIDN IDSIFHYAFH
2160 2170 2180 2190 2200
QITKNVEAIN MDTLDISFGA KTIGAIILHD QSIKRGWKLK NFIIASSVTS
2210 2220 2230 2240 2250
SLGSESQCSY VCANNVLESF SQYRKSLGLP SICTSYGLIK STGFVSRNEN
2260 2270 2280 2290 2300
VSVMFENLGF NPLSINTILG SLDLQIQNQE LSTNLIVSSF NFSNITKYNP
2310 2320 2330 2340 2350
QKNNFSKIDY QVSLEEKNKV NQLGHDGNQD NKNSVNQMFL EKVSEVLSIE
2360 2370 2380 2390 2400
ISKINIDIKL SAYGADSLSI VQLKNWVDKE LSGNIITIQQ LQTNTISSSI
2410 2420 2430 2440 2450
KIITNSLDKK KEGKNKSSTV VNNTNEITTT TKTFEYWKNE AKLDETIIAS
2460 2470 2480 2490 2500
SIKSDLIIDN KMDKVILLSG STGFLGGYLL LNLVKMKNCS KIYCLTRSGH
2510 2520 2530 2540 2550
LSDQIDLMNK IIDNLKHHKL FEMFEQSELE KIFPVRGDLR KSKLGLSDKM
2560 2570 2580 2590 2600
YLEISNQVNL ILSCGADINL NANYDEIKPT NVDSTKEFIK LSVSKGTNKP
2610 2620 2630 2640 2650
MIPIVNLSSF SIFFGQKLND EIEFDEYQVG IPSLSNLNNL PGGYIQSKLI
2660 2670 2680 2690 2700
CEHLLLEASS RGIPAMTIRL PSIFSNPHTG IGHSGDLLQL IIKSISVTKY
2710 2720 2730 2740 2750
FPIEPTSLFI SPVTWVAQNI INLIFNEGCW SKTKINTLNI ISLNGELQTT
2760 2770 2780 2790 2800
NEIFLMIKKN FNYKETTLIN WKKMISESND KTCIRLRTFH PLDFTPTKYH
2810 2820 2830
MSKEFKISKN TKSLLISFGS YDGWNITEQM VLNLLKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000005 Genomic DNA Translation: EAL72850.1 |
RefSeqi | XP_646445.1, XM_641353.1 |
Genome annotation databases
EnsemblProtistsi | EAL72850; EAL72850; DDB_G0271000 |
GeneIDi | 8617404 |
KEGGi | ddi:DDB_G0271000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000005 Genomic DNA Translation: EAL72850.1 |
RefSeqi | XP_646445.1, XM_641353.1 |
3D structure databases
SMRi | Q55CN6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0235216 |
Proteomic databases
PaxDbi | Q55CN6 |
Genome annotation databases
EnsemblProtistsi | EAL72850; EAL72850; DDB_G0271000 |
GeneIDi | 8617404 |
KEGGi | ddi:DDB_G0271000 |
Organism-specific databases
dictyBasei | DDB_G0271000, pks3 |
Phylogenomic databases
eggNOGi | KOG1178, Eukaryota KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | Q55CN6 |
PhylomeDBi | Q55CN6 |
Miscellaneous databases
PROi | PR:Q55CN6 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF07993, NAD_binding_4, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS3_DICDI | |
Accessioni | Q55CN6Primary (citable) accession number: Q55CN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase