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UniProtKB - Q55CE0 (MKCF_DICDI)
Protein
Probable serine/threonine-protein kinase mkcF
Gene
mkcF
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Catalytic activityi
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 428 | ATPPROSITE-ProRule annotationBy similarity | 1 | |
Active sitei | 519 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 407 – 415 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable serine/threonine-protein kinase mkcFImported (EC:2.7.11.1)Alternative name(s): MAP kinase cascade FImported |
Gene namesi | Name:mkcFImported ORF Names:DDB_G0270102 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0270102, mkcF |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000381744 | 1 – 677 | Probable serine/threonine-protein kinase mkcFAdd BLAST | 677 |
Proteomic databases
PaxDbi | Q55CE0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 58 | SH3PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 401 – 646 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 246 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 72 – 244 | DisorderedSequence analysisAdd BLAST | 173 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 72 – 148 | Polar residuesSequence analysisAdd BLAST | 77 | |
Compositional biasi | 158 – 191 | Polar residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 192 – 226 | Basic and acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 227 – 244 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STE20 subfamily.PROSITE-ProRule annotation
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG0578, Eukaryota |
HOGENOMi | CLU_406240_0_0_1 |
InParanoidi | Q55CE0 |
OMAi | MLWQCFE |
PhylomeDBi | Q55CE0 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q55CE0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLYLVATGDY KGPSENHLSF TKGQRIEFLE RTENGFIKGK LDGKVGIFPS
60 70 80 90 100
SLITIETRPL SIIQNQPIKY STETKDDTGS ISSSTSTSTS SLTTPRAESS
110 120 130 140 150
KDASGEQQPS TSTINGQSSS TSPILQSNGT TNTTTSSTSN NNIGDNISEK
160 170 180 190 200
SFGDYDDTTS NHSKSASRLS VASFSTTTTA TTTTTTTTTA TSSKDKDKKD
210 220 230 240 250
KKEKKEKKDK KSKDDDKSEK EGLYRKSKGS SSSSSSSSSS TKRRYANRKA
260 270 280 290 300
CEPWVVKKYE DIPEEVKSDM LKEDIPIKDI QDHFKLFLRI LKFITRQKIT
310 320 330 340 350
LLIPIDPTIP TKEMNLLDLS DAESVAKSTT MFTREEIRTS AFDNVDAFVD
360 370 380 390 400
APIMDDNEKA AKTTEIKLER KRILTGISTE FLGQASTTIR VIPSSDIKKR
410 420 430 440 450
IKFTHMVGRG QYGKVYDALY DKKRVCVKVV NYSTPKEQHN VLQEIGFLTQ
460 470 480 490 500
CDHPNILKYN CSVLYGSDLF IVSEFIQGGT LEQASASSHV FKETQVGFIG
510 520 530 540 550
LELLKAISYL HEKKLIHRDI KAANVMVSTD GEVKLIDFGL CASVEKGGSQ
560 570 580 590 600
HMVGSPYYMS PEMIRGEECS YPSDIWSFGI CILELLFKKP PHRDSRMKAM
610 620 630 640 650
FYNAINGIDF PKIRCSIDLK DMLWQCFESN PEKRSTVDKL MRHPFFKRCE
660 670
SKSQMKSVFT DMFSTSSKNS ISTTGFF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000005 Genomic DNA Translation: EAL72401.1 |
RefSeqi | XP_646541.1, XM_641449.1 |
Genome annotation databases
EnsemblProtistsi | EAL72401; EAL72401; DDB_G0270102 |
GeneIDi | 8617507 |
KEGGi | ddi:DDB_G0270102 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000005 Genomic DNA Translation: EAL72401.1 |
RefSeqi | XP_646541.1, XM_641449.1 |
3D structure databases
AlphaFoldDBi | Q55CE0 |
SMRi | Q55CE0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0229970 |
Proteomic databases
PaxDbi | Q55CE0 |
Genome annotation databases
EnsemblProtistsi | EAL72401; EAL72401; DDB_G0270102 |
GeneIDi | 8617507 |
KEGGi | ddi:DDB_G0270102 |
Organism-specific databases
dictyBasei | DDB_G0270102, mkcF |
Phylogenomic databases
eggNOGi | KOG0578, Eukaryota |
HOGENOMi | CLU_406240_0_0_1 |
InParanoidi | Q55CE0 |
OMAi | MLWQCFE |
PhylomeDBi | Q55CE0 |
Miscellaneous databases
PROi | PR:Q55CE0 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MKCF_DICDI | |
Accessioni | Q55CE0Primary (citable) accession number: Q55CE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 1, 2009 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families