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Entry version 66 (22 Apr 2020)
Sequence version 1 (24 May 2005)
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Protein

Integrator complex subunit 2 homolog

Gene

ints2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-6807505 RNA polymerase II transcribes snRNA genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrator complex subunit 2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ints2
ORF Names:DDB_G0271040
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0271040 ints2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003443741 – 1362Integrator complex subunit 2 homologAdd BLAST1362

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q55CB6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0234072

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q55CB6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 12Poly-Asn8
Compositional biasi45 – 62Poly-AsnAdd BLAST18
Compositional biasi582 – 585Poly-Asn4
Compositional biasi586 – 654Thr-richAdd BLAST69
Compositional biasi637 – 708Ser-richAdd BLAST72
Compositional biasi795 – 798Poly-Leu4
Compositional biasi937 – 944Poly-Asn8
Compositional biasi958 – 964Poly-Glu7
Compositional biasi1270 – 1276Poly-Asn7
Compositional biasi1279 – 1287Poly-Asn9
Compositional biasi1296 – 1305Poly-Asn10

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Integrator subunit 2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH4R Eukaryota
ENOG410XYV2 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007707_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q55CB6

KEGG Orthology (KO)

More...
KOi
K13139

Identification of Orthologs from Complete Genome Data

More...
OMAi
VANFPDC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q55CB6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026236 Int2_metazoa
IPR029321 INTS2

The PANTHER Classification System

More...
PANTHERi
PTHR28608 PTHR28608, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14750 INTS2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02105 INTSUBUNIT2

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q55CB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITSNNNNKN NNKKDVEMKS NEEEGDEIFF SILSGDTNNL FKFLNNNNSN
60 70 80 90 100
NNNNNNNNNI NNSIDIYLPY IIVGILEKNK DLLDEDENLK KLFYSPIYSK
110 120 130 140 150
SIHNINQYQS LNFDHINEFI KDQVRIRKKL NHVNQDKKDT YLDNIDNPKY
160 170 180 190 200
QFENGDKEVK MKLVLSDIIA LLEFSEMQQS LTISKETKYD APFIDTPIYN
210 220 230 240 250
NELNLIFPII CYKCLKHIDF NKLTLSILFL NQANYLIKLL LSNNPNEFNE
260 270 280 290 300
IIEIVISSIG LIGVEKVKRV LLEICKLSKY CSRFIRTELI NRQMLPDLVL
310 320 330 340 350
LITSQFVKDE IDLLSNIISN RIENQWLKEY ISQKDQFSTF NEIRDSLFST
360 370 380 390 400
LELISKEISS NSNNNSNNLE HSFIVKSIIR LYCGFSGLLG IKMNQQEISI
410 420 430 440 450
SLSFIEKSIF KNYSKIFLCF LLVCEGLVKT IHPKKELVGY LNHLCKVGNC
460 470 480 490 500
DELLLLISIY FHTHQLQNIA LLVKNILGFR PSIHTESLNQ IGEILTKEIY
510 520 530 540 550
TESLVAKRAQ QLPIIEKLNT NHQNISIVCV YHLLSERIFE KYETDVGNWC
560 570 580 590 600
WSQLTKSSTP IHYLLPSLLD QLCKNIIEPS INNNNTSSTT SIINTSTTAA
610 620 630 640 650
AASTTASNAN TTAATTTTTT AATITTATTT GTTTGISPSS STTTTSSTGG
660 670 680 690 700
ATSTSISSPN STSLGNSYLF STFSSTSSSS SSGLPFYMKR ISESIIMNSI
710 720 730 740 750
QQSQSNLSVQ ILIIYFVLRY NDSVIKFKSE QKGKPIQFLI ETTQLREYNI
760 770 780 790 800
EFLSKLPIQN CINVILSNQS DYFYIIPPFL YLILSQFPQF FNINLLLLEE
810 820 830 840 850
ERLLNPIEKF IYLPNFYSIN GGANNNSGGI TNEFLKDTLK RTLSQPTSVQ
860 870 880 890 900
LILRYLNTLS VKELLPFTTT LLDNLLPIII KNRSLPSVSA LISPFVEIWE
910 920 930 940 950
RVFPISQSSI ALKTINILTC INDDKSTNNN KDLEDYNNNN NNNNDDVKMK
960 970 980 990 1000
DKEKEDKEEE EEEEILLPIS NYTYTDIISD PLVIFRSHPT VFTCPPLFKI
1010 1020 1030 1040 1050
LLQILFFYMV SSKKNLQNQL HTSSGSGSGT TSNVTLNKQQ QEDVSTLILT
1060 1070 1080 1090 1100
QESTIIQILL EICLIDGIDT KGLNKILRNK NKKFKESYDP VDIEEIRCQI
1110 1120 1130 1140 1150
CSFIHQMFID KPLIIKLVHF QGYLSQLLPI TVTLIPSMHI CFEFIPELLA
1160 1170 1180 1190 1200
QPSLEKQIFA IQLLSYLSEK FPIPKSLKIC RQSQTRISFN LNSNTLSYDD
1210 1220 1230 1240 1250
RIKFLHSILP SITRITKTFP LLAEDFVSIL MEQLPNKHNY QQNLKSFISS
1260 1270 1280 1290 1300
IDFNLNSNLN NYTNSIYLQN NKNNNNSSNN NNSNNQNDLL NIDIDNNINS
1310 1320 1330 1340 1350
NNNNNLRNIN FKKVSNDDKS FFSKVSKNES WLSIKENNDP FNIPIEQEIH
1360
QAIQIIIKNL SK
Length:1,362
Mass (Da):155,569
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC57946A4A7F55952
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72870.1

NCBI Reference Sequences

More...
RefSeqi
XP_646565.1, XM_641473.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL72870; EAL72870; DDB_G0271040

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8617533

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0271040

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72870.1
RefSeqiXP_646565.1, XM_641473.1

3D structure databases

SMRiQ55CB6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0234072

Proteomic databases

PaxDbiQ55CB6

Genome annotation databases

EnsemblProtistsiEAL72870; EAL72870; DDB_G0271040
GeneIDi8617533
KEGGiddi:DDB_G0271040

Organism-specific databases

dictyBaseiDDB_G0271040 ints2

Phylogenomic databases

eggNOGiENOG410IH4R Eukaryota
ENOG410XYV2 LUCA
HOGENOMiCLU_007707_0_0_1
InParanoidiQ55CB6
KOiK13139
OMAiVANFPDC
PhylomeDBiQ55CB6

Enzyme and pathway databases

ReactomeiR-DDI-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q55CB6

Family and domain databases

InterProiView protein in InterPro
IPR026236 Int2_metazoa
IPR029321 INTS2
PANTHERiPTHR28608 PTHR28608, 1 hit
PfamiView protein in Pfam
PF14750 INTS2, 2 hits
PRINTSiPR02105 INTSUBUNIT2

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINT2_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q55CB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 24, 2005
Last modified: April 22, 2020
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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