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Protein

Very-long-chain enoyl-CoA reductase

Gene

gpsn2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.By similarity

Catalytic activityi

A very-long-chain acyl-CoA + NADP+ = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH.By similarity

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNADP

Enzyme and pathway databases

ReactomeiR-DDI-75876 Synthesis of very long-chain fatty acyl-CoAs
UniPathwayi
UPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Very-long-chain enoyl-CoA reductaseCurated (EC:1.3.1.93By similarity)
Alternative name(s):
Synaptic glycoprotein SC2-like protein
Trans-2,3-enoyl-CoA reductase
Short name:
TER
Gene namesi
Name:gpsn2
ORF Names:DDB_G0270270
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270270 gpsn2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003281511 – 300Very-long-chain enoyl-CoA reductaseAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ55C17

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0237530

Structurei

3D structure databases

SMRiQ55C17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1639 Eukaryota
ENOG410XR2S LUCA
InParanoidiQ55C17
KOiK10258
OMAiQIAWRTV
PhylomeDBiQ55C17

Family and domain databases

InterProiView protein in InterPro
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039357 SRD5A/TECR
PANTHERiPTHR10556 PTHR10556, 1 hit
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q55C17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDIKVVSQR SKKEVGSFST SSSTTVGELK KQISSKTRLG TERIRLAVPS
60 70 80 90 100
KTSKLPNAFE ALGKDSDLVS KHVGADSTLY FKDLGPQISW SLVFICEYAG
110 120 130 140 150
PLFVYPIFYF LSNLIYGTDS PKSFAQKVAL VCYSLHYIKR IYETIFVHRF
160 170 180 190 200
SHGTMPIFNL FKNCSYYWGC TAMVSYFVNH PLYTEAPIER VYLGLGLWII
210 220 230 240 250
GEVFNYICHI QLRNLRPAGS TERKIPRGLL FEFVSCPNYT VEILSWIGFS
260 270 280 290 300
ILTQTLTSWI FALMGAAQMW IWAVGKHRRY RKEFGDKYPK SRKILIPFLL
Length:300
Mass (Da):34,378
Last modified:May 24, 2005 - v1
Checksum:iB9C17B6D31C118C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72485.1
RefSeqiXP_646664.1, XM_641572.1

Genome annotation databases

EnsemblProtistsiEAL72485; EAL72485; DDB_G0270270
GeneIDi8617636
KEGGiddi:DDB_G0270270

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72485.1
RefSeqiXP_646664.1, XM_641572.1

3D structure databases

SMRiQ55C17
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0237530

Proteomic databases

PaxDbiQ55C17

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL72485; EAL72485; DDB_G0270270
GeneIDi8617636
KEGGiddi:DDB_G0270270

Organism-specific databases

dictyBaseiDDB_G0270270 gpsn2

Phylogenomic databases

eggNOGiKOG1639 Eukaryota
ENOG410XR2S LUCA
InParanoidiQ55C17
KOiK10258
OMAiQIAWRTV
PhylomeDBiQ55C17

Enzyme and pathway databases

UniPathwayi
UPA00094

ReactomeiR-DDI-75876 Synthesis of very long-chain fatty acyl-CoAs

Miscellaneous databases

PROiPR:Q55C17

Family and domain databases

InterProiView protein in InterPro
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039357 SRD5A/TECR
PANTHERiPTHR10556 PTHR10556, 1 hit
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTECR_DICDI
AccessioniPrimary (citable) accession number: Q55C17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 18, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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