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UniProtKB - Q559A9 (PKS13_DICDI)
Protein
Probable polyketide synthase 13
Gene
pks13
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 176 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 631 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks13 ORF Names:DDB_G0272981 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0272981, pks13 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000376886 | 1 – 2551 | Probable polyketide synthase 13Add BLAST | 2551 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2502 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | Q559A9 |
PRIDEi | Q559A9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2465 – 2542 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 157 – 210 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 621 – 654 | Acyl/malonyl transferaseAdd BLAST | 34 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | Q559A9 |
PhylomeDBi | Q559A9 |
Family and domain databases
Gene3Di | 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q559A9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENFKYRNNE NDVAIIGIGF RLPGCKNFTP NELWNNLKNG FNGVVELSNR
60 70 80 90 100
WSDNFYTMGK VSSAYAGLLP FDELKSFDPL FFGINPTEVP TIDPQQRILL
110 120 130 140 150
KCTWEAFEDA GIDPIKIRGS NTSVFIGTST NDYQRIIREK DQTITNAFGT
160 170 180 190 200
SLHATSNRIS YCFDFRGPSM TLDTACSSSL NCVKLGYQSI RDGTSNLSIA
210 220 230 240 250
GGVNLIIDPY FTASISDLNI LSKTGSCKTF DASADGFARA EGSGIIVMKN
260 270 280 290 300
LKQAMIDGDK IYCVIKGASS NVDGGGLQDK SNFYAPSSLS QCNNIKMALK
310 320 330 340 350
STNGTVEPKD ISYFECHGTG TPTGDPIETR GISMVFNDES RSKENPLLIG
360 370 380 390 400
SIKSNIGHLE AGSGIASLIK CCLMFKNKCF APNINFKVPN PKIKFEEWNL
410 420 430 440 450
KVVTEPIQFT KSNTCIGLSN FGVTGSNCCL ILSQFNNNNN DNQIVGNNNN
460 470 480 490 500
IKSNKEYLIP FSSNSVKSLE NYQQLLIKNG ENEFKFLEFI KHQIFTKPTS
510 520 530 540 550
LYQRSVVIAS SWDQFNNAKI MKTSNSKSSN ISIERNNPIT VFVFCGQGSQ
560 570 580 590 600
YDRMGLELYN NDFIFKESMD LLDNKLSKYY GYSVLEKLRN CDSKSIQHPM
610 620 630 640 650
IAQPVMCMFN ISLFELYKHW GIEVSFIIGH SLGEIPAAYC SGMINIDTLC
660 670 680 690 700
YLIYHRSIAQ TKTHTNGRML SINISADEYF SQYSKQYPDI EIACFNSPTS
710 720 730 740 750
IVIAGNEQKL NEISEILKEK GIFSAMLASL SSFHTSSQNK VKEDIVNKQF
760 770 780 790 800
DSKQSEIPIF STVTTNLFDS VTSPFNSSYV FNNIVSPVKF SQTISNLYKH
810 820 830 840 850
IESNQLGNDI VFIELAPHPT LQFYLKQMIP KPTNDDNSIE FKVSVYSALN
860 870 880 890 900
KKNNDIEEIQ RTISQLYCDN GYNVNFKCQF QHDDTHGSIN SNINQLSNIS
910 920 930 940 950
LPHYQWDDEK YWKEDPSISK LIVNGPQTDN LGYLNENSPN SKSYETFIDI
960 970 980 990 1000
KRPPFQYLKG HMVKGKYYFP GCGYIDNLLK IYKSQDLTIN QMGFKSPLIF
1010 1020 1030 1040 1050
IEGVNQALQT NIFKKSTSNT TTNNNDEFRV EYHFNDQKTN RWILSSFGDF
1060 1070 1080 1090 1100
QLSNHSSNSD NLEKINIKQL IQNQCNLTKL SRDELYSHIK SKTGLTYNGV
1110 1120 1130 1140 1150
FQGVNKCYLG ENCSLSEVSL ELKREPSSFF NTAVLDTCLH GMLCLLEEQS
1160 1170 1180 1190 1200
QLVFDRIEGF KYHSSNVPTS EEEMKIHSNI YVYSTINPSR IGDSYSASIV
1210 1220 1230 1240 1250
IMMEDGTVLI EIENAVCTSL TPIKESISVK YPTNQLFSMY LQSKDSPIPS
1260 1270 1280 1290 1300
PLNFKSLYNQ NQQQLKIDKQ FTDWMQKCEK FISNQFFKNI EKRNPEINLE
1310 1320 1330 1340 1350
ILNSKTIIEL KSKYCQNLKN ERLFQFVFET IKQLGVNAYD DDDDLTIDSS
1360 1370 1380 1390 1400
EDRKSIYEIL IKSTKVIPKL LFPLEDEDLT IDSPQSLFEN GLLDRFYNNP
1410 1420 1430 1440 1450
NLMTNQCQLI AQIIKESLKP LLNKKMVFRI LEMGGGTCSL SVVVLNLINQ
1460 1470 1480 1490 1500
LLLENPSFEI DIEYTWSDIS PSFISAAKEK LSHIDKRINI LYRSIDIEQP
1510 1520 1530 1540 1550
FIEKQDLSPS YYDFVIMSNV LHVVKKLSPS LDEIHKILTP NGHLLFVEIP
1560 1570 1580 1590 1600
YKELISDSIF GAFNQWWAFE DTDIRKDRCS IPPNQWIQVL SNHNYKDTIV
1610 1620 1630 1640 1650
SDNKECTWCC FVIHSQKPSL LELSKKIECN QYDNIIVFGN ENSQDNFTKS
1660 1670 1680 1690 1700
IKLSYNNNII KWVSNIVEIK KFIKLNIITN NSIIYFTKGI EELTIDNFKL
1710 1720 1730 1740 1750
INFQYIQINQ LLLKYESKCK NVLVTRDCDG SNYLASSLIG AARYFDEYRQ
1760 1770 1780 1790 1800
LELFTLDFDN DTIQSCDECS SSSCSNLIKL IEPLIDPKIN IQREFLIRNN
1810 1820 1830 1840 1850
RVYFERAKLE TNLKKSFKSE SFENSNKLIS TLNFNLDYQL QSKPFKQLLQ
1860 1870 1880 1890 1900
NEIEVEIKAT GINYRDYLVF TGSLPIEKTN HNGISNQPEF GVDFSGIVTK
1910 1920 1930 1940 1950
VGGGGGNGEF KVGDRVYGIG HNTTSSHITI DSRYASLIPN SLDYIEASSI
1960 1970 1980 1990 2000
TSSYILSLYG IFDIGNLDIQ DNESILIHSG TGGIGLSALN SLRWKGHKSH
2010 2020 2030 2040 2050
LFVTVSSKEK EQYLRDNYGS FITGIYSNKD KNYPKLIKEK LNQLGSNKQG
2060 2070 2080 2090 2100
VDLILSSLPN GDDNLNFKCL AKNGRIIDLS NNIDLFNISK SKIKKLLNTI
2110 2120 2130 2140 2150
NDGFESGELQ VIPIIEFSNS NIRDAIEFIN ERQHIGKIVI SHDDSNLLID
2160 2170 2180 2190 2200
LINKHSNQPN YSILKSDYQI SQSNLGKNIL ITGQSGIVLE ILKWIIKFSN
2210 2220 2230 2240 2250
SIENVIILSK SLMKWELELL IGKTMKKANN KIKFHFKSVD VSDSIQVENS
2260 2270 2280 2290 2300
INQILNDNPN IVNIDSIFHF AFTQITKKVE EIDMESLNVS HNAKTIGAIN
2310 2320 2330 2340 2350
LHNQSINRNW RLNNFVMASS ATSIIGSTDQ CSYVCANTVL DSLSKYRKSI
2360 2370 2380 2390 2400
GLPSICTNYG AIESAGFVSK NESVAAMFNG IGIISISTDL ILGTLDLQIQ
2410 2420 2430 2440 2450
NQQSSTNLML SDFNFLNFVN NNLQLSLISK FDFQTNLAKN QVNEKLQNQT
2460 2470 2480 2490 2500
QNQNLQIQSP SSTTDCQTII KDSFLHKISE VLSIDISKLN LDLKLLDYGA
2510 2520 2530 2540 2550
DSLAIVQIKN WIDMEVSPNL IVIQQLQTFT ITSSIQYTIN SFLKKKVQSQ
E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000008 Genomic DNA Translation: EAL71128.1 |
RefSeqi | XP_644907.1, XM_639815.1 |
Genome annotation databases
EnsemblProtistsi | EAL71128; EAL71128; DDB_G0272981 |
GeneIDi | 8618586 |
KEGGi | ddi:DDB_G0272981 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000008 Genomic DNA Translation: EAL71128.1 |
RefSeqi | XP_644907.1, XM_639815.1 |
3D structure databases
SMRi | Q559A9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0230082 |
Proteomic databases
PaxDbi | Q559A9 |
PRIDEi | Q559A9 |
Genome annotation databases
EnsemblProtistsi | EAL71128; EAL71128; DDB_G0272981 |
GeneIDi | 8618586 |
KEGGi | ddi:DDB_G0272981 |
Organism-specific databases
dictyBasei | DDB_G0272981, pks13 |
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | Q559A9 |
PhylomeDBi | Q559A9 |
Miscellaneous databases
PROi | PR:Q559A9 |
Family and domain databases
Gene3Di | 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS13_DICDI | |
Accessioni | Q559A9Primary (citable) accession number: Q559A9 Secondary accession number(s): Q86IG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase