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Protein

Transcriptional repressor SmtB homolog

Gene

ziaR

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor of the expression of the ziaA gene. Controls zinc homeostasis by triggering ZiaA-mediated efflux of excess zinc into the periplasm.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20ZincPROSITE-ProRule annotation1
Metal bindingi26ZincPROSITE-ProRule annotation1
Metal bindingi71ZincPROSITE-ProRule annotation1
Metal bindingi73ZincPROSITE-ProRule annotation1
Metal bindingi114ZincPROSITE-ProRule annotation1
Metal bindingi116ZincPROSITE-ProRule annotation1
Metal bindingi127ZincPROSITE-ProRule annotation1
Metal bindingi130ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi72 – 91H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor SmtB homolog
Gene namesi
Name:ziaR
Synonyms:smtB
Ordered Locus Names:sll0792
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi71C → S: Loss of ability to respond to zinc. Still capable of binding DNA; when associated with S-73. 1 Publication1
Mutagenesisi73C → S: Loss of ability to respond to zinc. Still capable of binding DNA; when associated with S-71. 1 Publication1
Mutagenesisi116H → R: Loss of ability to respond to zinc. Still capable of binding DNA. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606271 – 132Transcriptional repressor SmtB homologAdd BLAST132

Proteomic databases

PaxDbiQ55940

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi1148.SYNGTS_2743

Structurei

3D structure databases

ProteinModelPortaliQ55940
SMRiQ55940
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 132HTH arsR-typePROSITE-ProRule annotationAdd BLAST95

Phylogenomic databases

HOGENOMiHOG000144506
InParanoidiQ55940
KOiK21903
OMAiCVADIAE
PhylomeDBiQ55940

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR018334 ArsR_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00846 HTH_ARSR_1, 1 hit
PS50987 HTH_ARSR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q55940-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSSLSKSQ SCQNEEMPLC DQPLVHLEQV RQVQPEVMSL DQAQQMAEFF
60 70 80 90 100
SALADPSRLR LMSALARQEL CVCDLAAAMK VSESAVSHQL RILRSQRLVK
110 120 130
YRRVGRNVYY SLADNHVMNL YREVADHLQE SD
Length:132
Mass (Da):15,083
Last modified:November 1, 1996 - v1
Checksum:i08A7B19849B186C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA10706.1
PIRiS77014

Genome annotation databases

EnsemblBacteriaiBAA10706; BAA10706; BAA10706
KEGGisyn:sll0792

Similar proteinsi

Entry informationi

Entry nameiZIAR_SYNY3
AccessioniPrimary (citable) accession number: Q55940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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