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Entry version 133 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Phosphoenolpyruvate synthase

Gene

ppsA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

By similarity

Miscellaneous

The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei442Tele-phosphohistidine intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei532SubstrateBy similarity1
Binding sitei601SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi703MagnesiumBy similarity1
Binding sitei703SubstrateBy similarity1
Binding sitei724Substrate; via carbonyl oxygenBy similarity1
Binding sitei725Substrate; via amide nitrogenBy similarity1
Binding sitei726SubstrateBy similarity1
Metal bindingi727MagnesiumBy similarity1
Binding sitei727Substrate; via amide nitrogenBy similarity1
Active sitei774Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoenolpyruvate synthase (EC:2.7.9.2)
Short name:
PEP synthase
Alternative name(s):
Pyruvate, water dikinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ppsA
Ordered Locus Names:slr0301
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1111708 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystisunclassified Synechocystis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001425 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001470391 – 818Phosphoenolpyruvate synthaseAdd BLAST818

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q55905

PRoteomics IDEntifications database

More...
PRIDEi
Q55905

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1148.1001788

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q55905

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal domain contains the ATP/Pi binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PEP-utilizing enzyme family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0574, Bacteria
COG1080, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q55905

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRFVQMY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q55905

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.60, 1 hit
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR008279, PEP-util_enz_mobile_dom
IPR006319, PEP_synth
IPR018274, PEP_util_AS
IPR000121, PEP_util_C
IPR023151, PEP_util_CS
IPR036637, Phosphohistidine_dom_sf
IPR002192, PPDK_AMP/ATP-bd
IPR015813, Pyrv/PenolPyrv_Kinase-like_dom
IPR040442, Pyrv_Kinase-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR43030, PTHR43030, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00391, PEP-utilizers, 1 hit
PF02896, PEP-utilizers_C, 1 hit
PF01326, PPDK_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000854, PEP_synthase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51621, SSF51621, 1 hit
SSF52009, SSF52009, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01418, PEP_synth, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00742, PEP_ENZYMES_2, 1 hit
PS00370, PEP_ENZYMES_PHOS_SITE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q55905-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSSVVEKTS VAHKETALIL WFEEVGTHDV GLVGGKNSSL GEMIQQLTNK
60 70 80 90 100
GVNVPSGFAT TAYAYRYFIQ EAGLEQKLRD LFTDLDVNDM ANLQERGHLA
110 120 130 140 150
RQLILDTPFP QNLQTAIAEA YGAMCERYGQ KMGRTGVDVA VRSSATAEDL
160 170 180 190 200
PEASFAGQQE TYLNVHSLSC VLESCHKCFA SLFTDRAISY RHHNGFDHFA
210 220 230 240 250
VALSVGVQKM VRSDLATSGV MFSIDTETGF KNAALITAAY GLGENVVQGA
260 270 280 290 300
VNPDEYFVFK PTLKEGFKPI LEKRLGSKAI KMVYDVGGSK LTKNVEVAEP
310 320 330 340 350
EREKYCINDE EILQLARWAC IIEDHYSGVR GVYTPMDIEW AKDGQTGELF
360 370 380 390 400
IVQARPETVQ SQKSANVIKT YELKDHSQVL ATGRSVGAAI GQGKAQVIRN
410 420 430 440 450
VSQINQFRPG EVLITNRTDP DWEPIMKQAS AIVTNQGGKT CHAAIIAREM
460 470 480 490 500
GIPAIVGCGD ATDTIKTGED VTICCSEGDE GSVYSGILNY EVHETELSNL
510 520 530 540 550
PRTKTQILMN VGNPEQAFGF ASYPADGVGL ARLEFIIANH IKAHPLALMK
560 570 580 590 600
FDELEDPLAK AEIAELTKLY AGDRPRFFVD KLAHGIAMIA AAFYPKPVVV
610 620 630 640 650
RMSDFKSNEY ANLLGGRQFE PKEENPMIGW RGASRYYDPN YREAYALECQ
660 670 680 690 700
ALKRVRDEMG LTNVIPMIPF CRTPDEGRKV IAEMAKHGLK QGKNGLEIYV
710 720 730 740 750
MCELPSNVIL ADEFSEVFDG FSIGSNDLTQ LTLGLDRDSS LVAHLFDERN
760 770 780 790 800
LGVKRMVKMA IETAKANGRK IGICGQAPSD YPEFAEFLVE LGIDSISLNP
810
DSVLKTVLRI AEVEKALG
Length:818
Mass (Da):89,929
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6A93834607733F5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA10668.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S76976

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAA10668; BAA10668; BAA10668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
syn:slr0301

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA10668.1
PIRiS76976

3D structure databases

SMRiQ55905
ModBaseiSearch...

Protein-protein interaction databases

STRINGi1148.1001788

Proteomic databases

PaxDbiQ55905
PRIDEiQ55905

Genome annotation databases

EnsemblBacteriaiBAA10668; BAA10668; BAA10668
KEGGisyn:slr0301

Phylogenomic databases

eggNOGiCOG0574, Bacteria
COG1080, Bacteria
InParanoidiQ55905
OMAiRRFVQMY
PhylomeDBiQ55905

Enzyme and pathway databases

UniPathwayiUPA00138

Family and domain databases

Gene3Di3.20.20.60, 1 hit
3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR008279, PEP-util_enz_mobile_dom
IPR006319, PEP_synth
IPR018274, PEP_util_AS
IPR000121, PEP_util_C
IPR023151, PEP_util_CS
IPR036637, Phosphohistidine_dom_sf
IPR002192, PPDK_AMP/ATP-bd
IPR015813, Pyrv/PenolPyrv_Kinase-like_dom
IPR040442, Pyrv_Kinase-like_dom_sf
PANTHERiPTHR43030, PTHR43030, 1 hit
PfamiView protein in Pfam
PF00391, PEP-utilizers, 1 hit
PF02896, PEP-utilizers_C, 1 hit
PF01326, PPDK_N, 1 hit
PIRSFiPIRSF000854, PEP_synthase, 1 hit
SUPFAMiSSF51621, SSF51621, 1 hit
SSF52009, SSF52009, 1 hit
TIGRFAMsiTIGR01418, PEP_synth, 1 hit
PROSITEiView protein in PROSITE
PS00742, PEP_ENZYMES_2, 1 hit
PS00370, PEP_ENZYMES_PHOS_SITE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPSA_SYNY3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q55905
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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