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UniProtKB - Q558Z0 (SYRC_DICDI)
Protein
Probable arginine--tRNA ligase, cytoplasmic
Gene
argS1
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.
By similarityCatalytic activityi
- EC:6.1.1.19By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 132 | L-arginineBy similarity | 1 | |
Binding sitei | 332 | L-arginineBy similarity | 1 | |
Binding sitei | 336 | L-arginineBy similarity | 1 | |
Binding sitei | 360 | L-arginineBy similarity | 1 |
GO - Molecular functioni
- arginine-tRNA ligase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- arginyl-tRNA aminoacylation Source: GO_Central
- mitochondrial translation Source: GO_Central
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19By similarity)Alternative name(s): Arginyl-tRNA synthetase Short name: ArgRS |
Gene namesi | Name:argS1 Synonyms:argS ORF Names:DDB_G0272867 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0272867, argS1 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: GO_Central
Other locations
- phagocytic vesicle Source: dictyBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000327521 | 1 – 589 | Probable arginine--tRNA ligase, cytoplasmicAdd BLAST | 589 |
Proteomic databases
PaxDbi | Q558Z0 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 121 – 123 | L-arginine bindingBy similarity | 3 | |
Regioni | 469 – 483 | Interaction with tRNABy similarityAdd BLAST | 15 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 121 – 132 | 'HIGH' regionAdd BLAST | 12 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
eggNOGi | KOG1195, Eukaryota |
HOGENOMi | CLU_006406_6_2_1 |
InParanoidi | Q558Z0 |
OMAi | YEFKWER |
PhylomeDBi | Q558Z0 |
Family and domain databases
CDDi | cd00671, ArgRS_core, 1 hit |
Gene3Di | 3.30.1360.70, 1 hit 3.40.50.620, 1 hit |
HAMAPi | MF_00123, Arg_tRNA_synth, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR001278, Arg-tRNA-ligase IPR005148, Arg-tRNA-synth_N IPR036695, Arg-tRNA-synth_N_sf IPR035684, ArgRS_core IPR008909, DALR_anticod-bd IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd |
PANTHERi | PTHR11956, PTHR11956, 1 hit |
Pfami | View protein in Pfam PF03485, Arg_tRNA_synt_N, 1 hit PF05746, DALR_1, 1 hit PF00750, tRNA-synt_1d, 1 hit |
PRINTSi | PR01038, TRNASYNTHARG |
SMARTi | View protein in SMART SM01016, Arg_tRNA_synt_N, 1 hit SM00836, DALR_1, 1 hit |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF55190, SSF55190, 1 hit |
TIGRFAMsi | TIGR00456, argS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
i Sequence
Sequence statusi: Complete.
Q558Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFQEEIAKQL SVLTEIEANK ILECIESTKN KDMADFAVPI PKLNKFKKLV
60 70 80 90 100
GKPDQLAIDF ASKIQLNDCI QGASATGNYL NFKVNRLLQV QEILKEVINQ
110 120 130 140 150
KEKYGMTEQG KGKKVIVEFS SPNIAKPFHA GHLRSTIIGN FMVNLFNELA
160 170 180 190 200
YETVSMNYLG DWGKQYGLLA VGFEKYGSEE ELLADPIKHL YNVYVQINGE
210 220 230 240 250
AEKEEEAKKK YAEEIAAGVE PTAPLQTTPT IHDTARAYFK RMEDGDAEAL
260 270 280 290 300
AIWKRFRDLS IVKYKDIYNR LNVKFDIYAG ESLVTEGMTI EFKKLQDKNL
310 320 330 340 350
LEDSQGAKVI DLSKPNKLGK VLVQKTDGTT LYITRDIAAA VDRKNNIGFD
360 370 380 390 400
KMYYVVASQQ DFHFRQLFDI LGKMDYQWQK DLTHINYGMV KGMSTRKGTV
410 420 430 440 450
VFLEDILNKT QKKMLKIMKQ NEQKFAEIED PEKVADIVGL SAVVIQDFNA
460 470 480 490 500
KRNKDYDFNW DRMLKSDGDT GPYLQYAHAR LCSLERKSGF EFNPNANLSL
510 520 530 540 550
LSEPEAFNLA ITIGRYPEII QLTHNQLEPS TLVGYLFELA HAVSSAHQVL
560 570 580
WIKDREKDVA EARFVLYWAA KVILGSGLRI LGLVPLERM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000008 Genomic DNA Translation: EAL71071.1 |
RefSeqi | XP_644926.1, XM_639834.1 |
Genome annotation databases
EnsemblProtistsi | EAL71071; EAL71071; DDB_G0272867 |
GeneIDi | 8618605 |
KEGGi | ddi:DDB_G0272867 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000008 Genomic DNA Translation: EAL71071.1 |
RefSeqi | XP_644926.1, XM_639834.1 |
3D structure databases
SMRi | Q558Z0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0231324 |
Proteomic databases
PaxDbi | Q558Z0 |
Genome annotation databases
EnsemblProtistsi | EAL71071; EAL71071; DDB_G0272867 |
GeneIDi | 8618605 |
KEGGi | ddi:DDB_G0272867 |
Organism-specific databases
dictyBasei | DDB_G0272867, argS1 |
Phylogenomic databases
eggNOGi | KOG1195, Eukaryota |
HOGENOMi | CLU_006406_6_2_1 |
InParanoidi | Q558Z0 |
OMAi | YEFKWER |
PhylomeDBi | Q558Z0 |
Miscellaneous databases
PROi | PR:Q558Z0 |
Family and domain databases
CDDi | cd00671, ArgRS_core, 1 hit |
Gene3Di | 3.30.1360.70, 1 hit 3.40.50.620, 1 hit |
HAMAPi | MF_00123, Arg_tRNA_synth, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR001278, Arg-tRNA-ligase IPR005148, Arg-tRNA-synth_N IPR036695, Arg-tRNA-synth_N_sf IPR035684, ArgRS_core IPR008909, DALR_anticod-bd IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd |
PANTHERi | PTHR11956, PTHR11956, 1 hit |
Pfami | View protein in Pfam PF03485, Arg_tRNA_synt_N, 1 hit PF05746, DALR_1, 1 hit PF00750, tRNA-synt_1d, 1 hit |
PRINTSi | PR01038, TRNASYNTHARG |
SMARTi | View protein in SMART SM01016, Arg_tRNA_synt_N, 1 hit SM00836, DALR_1, 1 hit |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF55190, SSF55190, 1 hit |
TIGRFAMsi | TIGR00456, argS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYRC_DICDI | |
Accessioni | Q558Z0Primary (citable) accession number: Q558Z0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families