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Entry version 102 (07 Oct 2020)
Sequence version 1 (24 May 2005)
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Protein

Probable serine/threonine-protein kinase irlB

Gene

irlB-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1056ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1033 – 1041ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-381070, IRE1alpha activates chaperones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable serine/threonine-protein kinase irlB (EC:2.7.11.1)
Alternative name(s):
Inositol-requiring protein-like protein kinase B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:irlB-1
ORF Names:DDB_G0273333
AND
Name:irlB-2
ORF Names:DDB_G0273857
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0273333, irlB-1
DDB_G0273857, irlB-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003620171 – 1448Probable serine/threonine-protein kinase irlBAdd BLAST1448

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q557G1

PRoteomics IDEntifications database

More...
PRIDEi
Q557G1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0266876

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1027 – 1293Protein kinasePROSITE-ProRule annotationAdd BLAST267
Domaini1296 – 1448KENPROSITE-ProRule annotationAdd BLAST153

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili666 – 817Sequence analysisAdd BLAST152
Coiled coili887 – 921Sequence analysisAdd BLAST35
Coiled coili974 – 1016Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi407 – 410Poly-Asn4
Compositional biasi412 – 424Poly-AspAdd BLAST13
Compositional biasi430 – 437Poly-Asn8
Compositional biasi825 – 829Poly-Gln5
Compositional biasi838 – 842Poly-Gln5
Compositional biasi943 – 954Poly-ThrAdd BLAST12
Compositional biasi983 – 1006Poly-AsnAdd BLAST24
Compositional biasi1166 – 1169Poly-Asn4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1027, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_251496_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q557G1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1440.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010513, KEN_dom
IPR038357, KEN_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit
PF06479, Ribonuc_2-5A, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51392, KEN, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q557G1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSLLNNLII DYEYDLIKVH HHIQKNIFIF PFKKQHYHST VLECLINLCS
60 70 80 90 100
KLKYDENENL NSLDQFKIIF YNESKFLNKN LKEYLEILKN SKEINKHVIC
110 120 130 140 150
DYFEKDNNGS EEKNQNSSIV FNFLNCFKDY LSMDIIEFIV RGISFQVRSY
160 170 180 190 200
CNLIKPIEQW KQKTYQQRYQ QFKKALHLNN EVYKRIVCNG VWKSEKLDYI
210 220 230 240 250
YRYKSDQLSL VGIIESDCSD LFISTLLIDS NSYEQLENVW RLICNFDSFS
260 270 280 290 300
IASKFLIEFF KLDKVNNKLN FSIHPSSDAN ENYKRTKTST NSNLSIDLVR
310 320 330 340 350
LLEFTTTNFS INVAKLLISK FPTFITSIPS RNSLWGIESR SSLNPIENHF
360 370 380 390 400
RILNCSFDFN NHQIPIDKQK DYINLFTKNL IHFNTEINEI EDLILKERYH
410 420 430 440 450
ISIRSINNNN HDDDDYDDYD DDDDHHSGCN NNNNNNNDGD HNEDENSIKE
460 470 480 490 500
ESLIEFSNYK VDSMISRLLK YNAPSTTIIA LLSNLVCNHM GVSQRILILS
510 520 530 540 550
TLIEEIQMIE SLLVQNDSFK TFMLCESMVS TPNRWSKQSI PLVFFAYIGS
560 570 580 590 600
DILNLKERPM FYKFFDLNPR LLLSIIPVPL IFKTFLSCSD IIRNNFEDDL
610 620 630 640 650
INFEDDDSSS VNFFGFTSNF SNSDQDYLSA LETCFENSNV FNDQQLKQMA
660 670 680 690 700
RKLLTFSKRE NQSRIAESEL LEELELEEKR KKQKQQEKIK KRLKREKRLK
710 720 730 740 750
EKQDLLLIKL EKQKEKQLEE QMKKREKKLQ KLERKRLYKK LQDDEKQKLI
760 770 780 790 800
EKQKQKEKEK ELSKQKEKEF ELLKQKEIDE IKQKSIQEID EINKNIQQNQ
810 820 830 840 850
LKIDEINKKL EIKEIQNFQL PLLNQQQQQP PPLQLLKQQQ QQPSSSLTIQ
860 870 880 890 900
LESITPILEP KNDNVVLLKS SIETPIDSVK KIQSIIEIQL EEENQKKKEM
910 920 930 940 950
ETIDEYEEIN INKKQINSNM KWGGIGEPSW ISVKKDNKKS KSTITTSTTP
960 970 980 990 1000
TTTTPAKVIT SQFKNEQTKK LIIENNKKQN LINDNNNNNN NNNNNNNNNN
1010 1020 1030 1040 1050
NNNNNNKLNN IIQDEDFVSI GKFKFNRNES NILGRGSNGT LVFKGLWSDK
1060 1070 1080 1090 1100
IPVAIKQMQK AFNPLINKEV EALISLTSKN CSNMIRYIDK EEDKLHVYLG
1110 1120 1130 1140 1150
LTLCDGSLQN LVESGKLNDF VISSNKSIIE LAKDILFGIQ FLHSHDIVHN
1160 1170 1180 1190 1200
DLNPRNILTL IGKTSNNNNS SNNSFIISDL GLSKMEVESS YSFTSNIPTG
1210 1220 1230 1240 1250
QGGYHPFEVL QSKRMTKSVD IFSLGCILFY LLTNGQHPFG NDKLFRIVNI
1260 1270 1280 1290 1300
ISNKMNLTPL NSNQLACTLI KSMISKDESI RPTIQNVLNH PLFWNLEKKI
1310 1320 1330 1340 1350
QFIDAALNLI KEPSNSSYNS KLTKQLNHCD DNDEPFLNDS WNHLIDVTNL
1360 1370 1380 1390 1400
LTPTKGSKIT ISYQYDKVRD LIRFIRNTIA HHKEIKRAII QQFQNQQSRP
1410 1420 1430 1440
NLEVLEYLSS QDSILLYFES KIPNLIHHIY QQLKQYSLTI DYLFNFYN
Length:1,448
Mass (Da):169,401
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB3B99A5E785ED2B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000011 Genomic DNA Translation: EAL70619.1
AAFI02000009 Genomic DNA Translation: EAL70884.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL70619; EAL70619; DDB_G0273857
EAL70884; EAL70884; DDB_G0273333

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0273333
ddi:DDB_G0273857

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA Translation: EAL70619.1
AAFI02000009 Genomic DNA Translation: EAL70884.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0266876

Proteomic databases

PaxDbiQ557G1
PRIDEiQ557G1

Genome annotation databases

EnsemblProtistsiEAL70619; EAL70619; DDB_G0273857
EAL70884; EAL70884; DDB_G0273333
KEGGiddi:DDB_G0273333
ddi:DDB_G0273857

Organism-specific databases

dictyBaseiDDB_G0273333, irlB-1
DDB_G0273857, irlB-2

Phylogenomic databases

eggNOGiKOG1027, Eukaryota
HOGENOMiCLU_251496_0_0_1
InParanoidiQ557G1

Enzyme and pathway databases

ReactomeiR-DDI-381070, IRE1alpha activates chaperones

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q557G1

Family and domain databases

Gene3Di1.20.1440.180, 1 hit
InterProiView protein in InterPro
IPR010513, KEN_dom
IPR038357, KEN_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PF06479, Ribonuc_2-5A, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51392, KEN, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRLB_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q557G1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: October 7, 2020
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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