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Entry version 88 (07 Oct 2020)
Sequence version 1 (02 May 2006)
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Protein

Homeobox protein 5

Gene

hbx5-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative transcription factor.By similarity

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1543 – 1607HomeoboxPROSITE-ProRule annotationAdd BLAST65

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein 5
Short name:
DdHbx-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hbx5-1
ORF Names:DDB_G0273127
AND
Name:hbx5-2
ORF Names:DDB_G0273645
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0273127, hbx5-1
DDB_G0273645, hbx5-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003887891 – 1723Homeobox protein 5Add BLAST1723

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q557C9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0266662

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q557C9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1553 – 1588EF-handPROSITE-ProRule annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili300 – 351Sequence analysisAdd BLAST52
Coiled coili1193 – 1270Sequence analysisAdd BLAST78
Coiled coili1431 – 1464Sequence analysisAdd BLAST34
Coiled coili1632 – 1702Sequence analysisAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 50Gln-richAdd BLAST43
Compositional biasi81 – 90Poly-Asn10
Compositional biasi118 – 137Poly-AsnAdd BLAST20
Compositional biasi142 – 154Poly-AsnAdd BLAST13
Compositional biasi158 – 170Poly-AsnAdd BLAST13
Compositional biasi173 – 213Poly-AsnAdd BLAST41
Compositional biasi214 – 219Poly-His6
Compositional biasi258 – 269Poly-AsnAdd BLAST12
Compositional biasi291 – 294Poly-Asn4
Compositional biasi301 – 350Poly-AsnAdd BLAST50
Compositional biasi374 – 377Poly-Gln4
Compositional biasi381 – 386Poly-Gln6
Compositional biasi387 – 508Ser-richAdd BLAST122
Compositional biasi514 – 524Poly-GlnAdd BLAST11
Compositional biasi547 – 567Poly-AsnAdd BLAST21
Compositional biasi609 – 724Ser-richAdd BLAST116
Compositional biasi729 – 732Poly-Pro4
Compositional biasi885 – 919Poly-AsnAdd BLAST35
Compositional biasi920 – 928Poly-Thr9
Compositional biasi958 – 968Poly-GlnAdd BLAST11
Compositional biasi1010 – 1015Poly-Gly6
Compositional biasi1057 – 1060Poly-Gln4
Compositional biasi1082 – 1085Poly-Asn4
Compositional biasi1088 – 1117Poly-AsnAdd BLAST30
Compositional biasi1193 – 1199Poly-Gln7
Compositional biasi1202 – 1210Poly-Asn9
Compositional biasi1243 – 1258Poly-GlnAdd BLAST16
Compositional biasi1287 – 1293Poly-Gln7
Compositional biasi1347 – 1354Poly-Asn8
Compositional biasi1357 – 1367Poly-AsnAdd BLAST11
Compositional biasi1371 – 1379Poly-Asn9
Compositional biasi1433 – 1462Poly-GlnAdd BLAST30
Compositional biasi1489 – 1498Poly-Thr10
Compositional biasi1638 – 1646Poly-Gln9
Compositional biasi1649 – 1660Poly-GlnAdd BLAST12
Compositional biasi1681 – 1712Poly-AsnAdd BLAST32

Keywords - Domaini

Coiled coil, Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502REC7, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_240221_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q557C9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048, EF_hand_dom
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 1 hit
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q557C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METIVNNQNN GQQNTVPTQS FSSSVYMNYD FFDSQQLQQP QHQPQHYQQQ
60 70 80 90 100
DSFVSPNLDN NNPQIHVQSN NYNQNGFVGY NNSNNNNNNN QHMNNQYSNS
110 120 130 140 150
FHNNNSSGFM AFQNNSSNFN NQNNNNSNNN NNNNNINSYD YNNSNNNNYN
160 170 180 190 200
NNNNTHSNNS NNNNNNNNSN YWNNNNNNNN NNNNNNNNNN NNNNNNNNNN
210 220 230 240 250
NSNNNNNNNN NNNHHHHHHQ QQSQPTSPYN NPIQHNPNDM KFNGQHNPFN
260 270 280 290 300
GNQMVMDNNN NNNNNNNSNV FNSNSNSNVF NSNSGSFLQI NNNNGSFSSY
310 320 330 340 350
NNNNNNNNNN NSNSNNNNNN NNNNNNNNNN NNNNNNNNNN NNNSNNNNNN
360 370 380 390 400
QFSQSYDSTL GNNRFSSMMG QPIQQQQSPP QQQQQQSFIQ SSPQAIPASN
410 420 430 440 450
CNGNGSTSSS TSPLSPTLIG SAPGTPTSML ATTLFGFNLS SSPTSSPSSP
460 470 480 490 500
VKKGKSQSAL ALSSSGGSGG SSGRKKPQKH DSMSSITNTN LKSTQASTLK
510 520 530 540 550
ESKRSNSSPN LKKQMQLQQL QQQQKLNENG TLIPPLPFAS ISENITNNNN
560 570 580 590 600
NNNNNNNNNN NNNNNNNITN NPLSGSMEFP NSNNINQSSD SINGEFNIGQ
610 620 630 640 650
PESPKMYNSS PSPPPNATST TKGGKKSKKS LHISTTQQSP SLNGSTGGSM
660 670 680 690 700
LTPTMSGLSL SGGGSGGGFS PLISPTGTTS NKDLQSSPSP SPLLKSMSMG
710 720 730 740 750
KLDLQDSIDS MSSPLSPNSS LSSSNGLLPP PPNSNNMNSS GGIPTPSTPT
760 770 780 790 800
SPPPLTHHIN IFSNLEFVKQ LKDHLLPNDF KPEEHALERN LLRFQQFVKT
810 820 830 840 850
LAEPLQRDVV TSMFELSVDA QLQYGSNLDN DNLSALMLFR RKILNFNLFR
860 870 880 890 900
MMMLNDPNSF IPLPSPFPIQ TTTISSNGTI VNPTNVNNNN INNNNNNNNN
910 920 930 940 950
NNNNNNNNNN NNNNNNNNNT TTTTTTTTSA NTVQSGTTSN SNLVFQQTSN
960 970 980 990 1000
SNTLSPSQQQ QQQTQQQQSI NGSSTGSLSD AQYQDLGIHL DTSSANSGCG
1010 1020 1030 1040 1050
INVSIGSSIG GGGGGSSLNG SNLNGSSSIS GSISGGSSNG GGQFIMSPQF
1060 1070 1080 1090 1100
SLDGAYQQQQ PSSYNINNEM ELAEKDEDEI FNNNNKDNNN NNNNNNNNNN
1110 1120 1130 1140 1150
NNNNNNNNNN NNNNNNNSSS INSNINNVNN CNINNNSNSN NGSINSPRPS
1160 1170 1180 1190 1200
TPTTLNSSGK RSKKIYRGDS FGAGNDISTG LMASSDQIIP PPQQQQHQQL
1210 1220 1230 1240 1250
VNNNNNNMNN SENNILLADS NKGLSVSLGS LPTNTPSSME IEQQQQQQQQ
1260 1270 1280 1290 1300
QQQQQQQQHL NQQQILHQQL HHHLSSSLGG AQFTNIQQQQ QQQSGNIFYN
1310 1320 1330 1340 1350
SPYNSSQVYM NPYGTSITNT SLAGPSTTSS AMQHMITNMT SSNIIVNNQN
1360 1370 1380 1390 1400
NNNNDQNNNN NNNNNNNSTT NSNVNNNNNT TNTPSSPPQP NNCTPTQTSI
1410 1420 1430 1440 1450
ITSNGVVVPS LQMRGTITNP PPVLPTPDTL VLQQQQQQQQ QQQQQQQQQQ
1460 1470 1480 1490 1500
QQQQQQQQQQ QQETPHTPTS NSISSPRSSP VHQQSPSNTN TTTTSTTTIR
1510 1520 1530 1540 1550
HSAVTQLSFA GLHNQQVSPI SPRSPRSPHG TSGDYNDGSQ SPSSRRKNRF
1560 1570 1580 1590 1600
TDFQIKRMND CFENLDKNNN GKFTSEEICQ IATELGLTDQ QVRVFFQNKR
1610 1620 1630 1640 1650
ARSRPSPRGQ PTNPLTSSTN NGNNSNLALQ HLQQQHLQQV QQQQQQLLQL
1660 1670 1680 1690 1700
QQQQQQQQQQ LHQQSANTTP QLNSMNPNSI NYNNNNNNNN NNNNNNNNNN
1710 1720
NNNNNNNNNN NNIINNNITT INE
Length:1,723
Mass (Da):188,913
Last modified:May 2, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF68A3B702B3FEB95
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000011 Genomic DNA Translation: EAL70513.1
AAFI02000009 Genomic DNA Translation: EAL70781.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL70513; EAL70513; DDB_G0273645
EAL70781; EAL70781; DDB_G0273127

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0273127
ddi:DDB_G0273645

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA Translation: EAL70513.1
AAFI02000009 Genomic DNA Translation: EAL70781.1

3D structure databases

SMRiQ557C9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0266662

Proteomic databases

PaxDbiQ557C9

Genome annotation databases

EnsemblProtistsiEAL70513; EAL70513; DDB_G0273645
EAL70781; EAL70781; DDB_G0273127
KEGGiddi:DDB_G0273127
ddi:DDB_G0273645

Organism-specific databases

dictyBaseiDDB_G0273127, hbx5-1
DDB_G0273645, hbx5-2

Phylogenomic databases

eggNOGiENOG502REC7, Eukaryota
HOGENOMiCLU_240221_0_0_1
InParanoidiQ557C9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q557C9

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR002048, EF_hand_dom
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit
PS50071, HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHBX5_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q557C9
Secondary accession number(s): Q8T248
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: May 2, 2006
Last modified: October 7, 2020
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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