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Entry version 109 (05 Dec 2018)
Sequence version 1 (24 May 2005)
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Protein

ABC transporter A family member 4

Gene

abcA4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi528 – 535ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1331 – 1338ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-1369062 ABC transporters in lipid homeostasis
R-DDI-382556 ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter A family member 4
Alternative name(s):
ABC transporter ABCA.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:abcA4
ORF Names:DDB_G0274121
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0274121 abcA4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Transmembranei1022 – 1042HelicalSequence analysisAdd BLAST21
Transmembranei1075 – 1095HelicalSequence analysisAdd BLAST21
Transmembranei1106 – 1126HelicalSequence analysisAdd BLAST21
Transmembranei1135 – 1155HelicalSequence analysisAdd BLAST21
Transmembranei1174 – 1194HelicalSequence analysisAdd BLAST21
Transmembranei1218 – 1238HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003638361 – 1615ABC transporter A family member 4Add BLAST1615

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q555Z5

PRoteomics IDEntifications database

More...
PRIDEi
Q555Z5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0219982

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q555Z5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q555Z5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 383ABC transmembrane type-2Add BLAST202
Domaini492 – 727ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1293 – 1528ABC transporter 2PROSITE-ProRule annotationAdd BLAST236

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPJI Eukaryota
ENOG410XXUP LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q555Z5

KEGG Orthology (KO)

More...
KOi
K05643

Identification of Orthologs from Complete Genome Data

More...
OMAi
KHIDKRT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q555Z5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q555Z5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESIKNQLIP LLKKNWTLKG KSKIKLLLEI LLPLISIGIL FGILYLSMII
60 70 80 90 100
TRDFKERPAS GFAFDIAHTK QLLIGSNGGL NSDQRNILDN LKLQVSIQHP
110 120 130 140 150
EFSNDYINRC FVEFKDIESM DEYFHDPFNY RGVMGGVWFP DDSFNGNTIK
160 170 180 190 200
YSIRVDSDFT HDNTQQFQDR EDSQIYLRHY FTQIQTGVDQ AILLTNQIAI
210 220 230 240 250
PIFATGQRFP NPYISFWEKW TDGRKLILLN TGGVFITASL FATLFTLITN
260 270 280 290 300
IVIEKETKIL EGMKTMGLNS FAYYISNSII SLITLLSSTL LVSIILSASQ
310 320 330 340 350
LVHHVKWITL ILILIPYSIT LLLIAFILCK FFTKSKYAGL MAFLIVLLLS
360 370 380 390 400
GIGIIIGRFN ISPTLKLLSC LFSPIAISVA NYVWCYKDLI VFKEVDINVN
410 420 430 440 450
MVNEYEIIGM LVFDIFLYIL ILWYLDNVIT GEYGIPKKWY FFLTKNYWRK
460 470 480 490 500
NKKSNINNNG VFDVEATSCN RNSSYNEKNF EKIEHQLERP TISIRNLRKE
510 520 530 540 550
FKTGDGNRIA VNDLSIDMYK NRIHSFLGPN GSGKSTTLSM LTGMIEPTSG
560 570 580 590 600
DALINGFDIR NNIDEIRKHL GVCPQSDIIW EQLTVMEHLE FYAALKGFTN
610 620 630 640 650
SNQRKVEATK IALEVGLGEK LNAPAGTLSG GQKRKLCLAI AFIGPNSDII
660 670 680 690 700
LIDEPTSGLD ASNRRLIWDF ILKYRENKTI ILVSHYLEEC DILSNTISII
710 720 730 740 750
ANGELKCNGS SLFLKNRFGV GYLLTISKEH NSINNSNLTK TISDIIFNHI
760 770 780 790 800
PKGSLLSDAG TELCFRLPNE SIGNFSNLFK ELDDRKKQLS IENYGISITT
810 820 830 840 850
LEEVFLKIIS NSETNPNFNQ SVLNTALKTN SSGIKSYQQL KGLLIKRVKT
860 870 880 890 900
SRKDIKSFVL SILIPILILA GGLILYKNMR TIDIYNTVTQ PLILDFNVYG
910 920 930 940 950
KSVTPVSIDK VNETMTSLFD NSIGHSDRTT LVPYDELHDY LIHHYFGVPG
960 970 980 990 1000
ALYFDFRYFK NVKFLHYNVF FNKDYLHALP IYINFVDSEI LRSVTGKRIQ
1010 1020 1030 1040 1050
TTSLPFEHIQ SPLEVASLDV NFVAIVFFII LTLASFSLIA ASHAGNISHE
1060 1070 1080 1090 1100
RSTRVKRLLY ISGLRKSIYW LSNLIWDYLQ TFILVIFLTI VIIAVDDKFR
1110 1120 1130 1140 1150
THFDLYISGV VLFTFSIIPL SYLMSFKFSS HGKAVGAIFA IHFGVGLIFT
1160 1170 1180 1190 1200
VISFILRVWA IKENSISFQF LTDIIEYCFY AISPFFCFSK ILAIVTKFPG
1210 1220 1230 1240 1250
VSRVDQSFID YWSFHFGLLP NAILFLHCIV WITWILLIDY SSEIKGKFTI
1260 1270 1280 1290 1300
SKLFSNSPIP DSNEDSDVSN ERIIVKQLLD NNTNGGSGNV YPIIFNNLYK
1310 1320 1330 1340 1350
KFNSVGNYKS KIAVYNSTLA IPTGQTFGLL GLNGCGKSTT LGMISGEISP
1360 1370 1380 1390 1400
TGGKIKLNGY DLIKNRNDAL TSIGYCFQFD ALIGLLSARE QLELYCRIKG
1410 1420 1430 1440 1450
VDESKIKDTV NAFIQMMDLE SISNSNTSGY SGGNKRKVSL SIACIGSPSI
1460 1470 1480 1490 1500
LLLDEISCGV DACVKRFMWN VLMELKKNKA IILTTHSIAE CQAVCDKLTI
1510 1520 1530 1540 1550
MKDGKLQALG SNQHIKDKFG SGYSIEVKFK KEYLENGVEL FLQSFPSASL
1560 1570 1580 1590 1600
IDNQHALSAS FELPNPPNNP IKLSSIFSNI EQSLKFILDD YSVSQTSIEQ
1610
IFIKLTKNSI TNIDN
Length:1,615
Mass (Da):182,397
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72AFF1ABFF583086
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29E → K in AAL85297 (PubMed:12456012).Curated1
Sequence conflicti38 – 45GILFGILY → D in AAL85297 (PubMed:12456012).Curated8
Sequence conflicti66I → N in AAL85297 (PubMed:12456012).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF465306 Genomic DNA Translation: AAL85297.1
AAFI02000012 Genomic DNA Translation: EAL69953.1

NCBI Reference Sequences

More...
RefSeqi
XP_643915.1, XM_638823.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL69953; EAL69953; DDB_G0274121

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8619342

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0274121

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465306 Genomic DNA Translation: AAL85297.1
AAFI02000012 Genomic DNA Translation: EAL69953.1
RefSeqiXP_643915.1, XM_638823.1

3D structure databases

ProteinModelPortaliQ555Z5
SMRiQ555Z5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0219982

Proteomic databases

PaxDbiQ555Z5
PRIDEiQ555Z5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL69953; EAL69953; DDB_G0274121
GeneIDi8619342
KEGGiddi:DDB_G0274121

Organism-specific databases

dictyBaseiDDB_G0274121 abcA4

Phylogenomic databases

eggNOGiENOG410IPJI Eukaryota
ENOG410XXUP LUCA
InParanoidiQ555Z5
KOiK05643
OMAiKHIDKRT
PhylomeDBiQ555Z5

Enzyme and pathway databases

ReactomeiR-DDI-1369062 ABC transporters in lipid homeostasis
R-DDI-382556 ABC-family proteins mediated transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q555Z5

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCA4_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q555Z5
Secondary accession number(s): Q86IX7, Q8T6J3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: December 5, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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