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Entry version 103 (12 Aug 2020)
Sequence version 1 (24 May 2005)
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Protein

Guanylyl cyclase, membrane

Gene

gca

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Synthesizes cyclic GMP (cGMP) from GTP, after activation by heterotrimeric or monomeric G proteins. Involved in chemotaxis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by guanosine 5'-3-O-(thio)triphosphate (GTPgammaS). Inhibited by calcium.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=55 µM for GTP3 Publications
  2. KM=340 µM for GTP3 Publications
  3. KM=200 µM for GTPgammaS3 Publications
  1. Vmax=75 pmol/min/mg enzyme toward GTP3 Publications
  2. Vmax=75 pmol/min/mg enzyme toward GTPgammaS3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1173Magnesium 1PROSITE-ProRule annotation1
Metal bindingi1173Magnesium 2PROSITE-ProRule annotation1
Metal bindingi1174Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi1217Magnesium 1PROSITE-ProRule annotation1
Metal bindingi1217Magnesium 2PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis, Chemotaxis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-2514859, Inactivation, recovery and regulation of the phototransduction cascade

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q553Y7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanylyl cyclase, membrane (EC:4.6.1.2)
Alternative name(s):
DdGCA
Short name:
GCA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gca
ORF Names:DDB_G0275009
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0275009, gcA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei907 – 927HelicalSequence analysisAdd BLAST21
Transmembranei982 – 1002HelicalSequence analysisAdd BLAST21
Transmembranei1016 – 1036HelicalSequence analysisAdd BLAST21
Transmembranei1040 – 1060HelicalSequence analysisAdd BLAST21
Transmembranei1061 – 1081HelicalSequence analysisAdd BLAST21
Transmembranei1094 – 1114HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi440E → K: Catalytic activity preferentially toward ATP instead of GTP, still activated by GTPgammaS; when associated with Q-502 and D-504. 1 Publication1
Mutagenesisi502S → Q: Catalytic activity preferentially toward ATP instead of GTP, still activated by GTPgammaS; when associated with K-440 and D-504. 1 Publication1
Mutagenesisi504H → D: Catalytic activity preferentially toward ATP instead of GTP, still activated by GTPgammaS; when associated with K-440 and Q-502. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003282161 – 1483Guanylyl cyclase, membraneAdd BLAST1483

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q553Y7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in vegetative cells; expression decreases approximately 3-fold during the aggregation stage, and then increases again during the later stages of development (mound, finger and slug).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By cAMP and osmotic shock.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191309

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q553Y7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini395 – 517Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST123
Domaini1168 – 1296Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi39 – 44Poly-Tyr6
Compositional biasi101 – 104Poly-Thr4
Compositional biasi226 – 233Poly-Phe8
Compositional biasi342 – 346Poly-Pro5
Compositional biasi720 – 765Poly-AsnAdd BLAST46
Compositional biasi945 – 958Poly-SerAdd BLAST14
Compositional biasi1411 – 1414Poly-Ser4
Compositional biasi1418 – 1421Poly-Glu4
Compositional biasi1425 – 1432Poly-Asn8
Compositional biasi1454 – 1463Poly-Asn10

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1023, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_249557_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q553Y7

Identification of Orthologs from Complete Genome Data

More...
OMAi
FRVANMA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q553Y7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054, A/G_cyclase
IPR029787, Nucleotide_cyclase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00211, Guanylate_cyc, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044, CYCc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55073, SSF55073, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50125, GUANYLATE_CYCLASE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q553Y7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFGNLPDVR KPKEGYKKYL EYFDLRFPRI QEEKHFQSYY YYTYLKQIRI
60 70 80 90 100
SIIFLTSVLF IGTMTAYISP LDISYLPYYD SKNIYYFNYV QPNVTTTSSS
110 120 130 140 150
TTTTSSTTNS IDSTVENNNF TEADGHLTNY YFPYLANKAR DTFILRMITI
160 170 180 190 200
GLLLFYFIFT FTAKFKRLWK LFTTITLFLV SCIVLIFESD IRTIPGRMVL
210 220 230 240 250
LFIIIAISSG MTFLPSMLAS GGLCLFFFFY FMFYSQIAGK QMVLLSLVLL
260 270 280 290 300
ISWIILMIIS RFKEQLFRDK FRTLENLKIQ TIRSEKIINQ MLPTVVVQRL
310 320 330 340 350
RLQSSKDQSL ETTLENDKEL SIKKDEESNL TGKKQSKVVV SPPPPPTAAA
360 370 380 390 400
PQQQDNEIST PQNSRKIVDP QSPSSLMPGQ YSVTDLIVDS YDPVTVLFCE
410 420 430 440 450
IVNFNALVEK MSSTQVINLL NEVYNSFDRL TDVYGVTKVE HIGNVYMVVG
460 470 480 490 500
GCPELCPDHA QRVAHMSLGM LSVIRRFGIV QVRIGMHTGP VVGGIIGKKK
510 520 530 540 550
LSWHLFGDTI NTSSRMASHS SIGRIQVSHP VQQLLRPYFL FEDRGKIQVK
560 570 580 590 600
GKGLMRTFYL VKTKQLDKRY TSIFSSLHRE KPYIPPVDIS EVSFENQNNT
610 620 630 640 650
IGKGDDIASG SATGPTHPNI PNSMLSAIPS RVSIEMNPLG GSGSIQKRER
660 670 680 690 700
KGSIFANVMP PKVLNFLQTG SLTSPQQQPL PQQSNSEETI SNSPRLSSTP
710 720 730 740 750
QSTSTLQHSS STGALGSLIN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
760 770 780 790 800
NNNNNNNNNN NNNNNLPVSL ISPISQNTTP TGSLSLPVTE KKKQTVQFGS
810 820 830 840 850
ISRSSSISKG TVGRSPSPAL FDGGIEMDDN GGGAGDDFNT MEPNLDLGKG
860 870 880 890 900
IHGSNVISTN NSKLNKLEKD LTKHYTLDKF KLSFISRGNL VEKEYRNEYI
910 920 930 940 950
LKNWNRILAS MLMIVALFGL SGLVDYFFLK LSSISSIVKV EPMPSSSSSS
960 970 980 990 1000
LSSSSSNSMT SSEEKFITLH TIRSEENLIY DIITGVRYGF VFFCLIVIYV
1010 1020 1030 1040 1050
VSKFKTFSIR KWIQEVVMVF FIVLAAVLIV LTSVPPLNKI PLDSVILSIE
1060 1070 1080 1090 1100
IMFITICYNF SGIKFWYSNI VCAFCIIFIE ISKTWKQAYH SRDIYLSHNY
1110 1120 1130 1140 1150
YLITAVLINI ITSYFEELFN RLNWVHGRLL DKDQRETESL VAEILPADIV
1160 1170 1180 1190 1200
KSMKSGRQLI VDEFKNVTIF LSDIVGFTEM AARMSPRQLV ETLNQIYSTF
1210 1220 1230 1240 1250
DEIAQEFGVL KIATIGDAYF CVSGCPDKDQ TDHAFRVANM AIKMLESIKS
1260 1270 1280 1290 1300
IRTVDNIPIR MRIGIHTGPV IAGVVGIKMI HYQLWGESVQ ITQQMESTSR
1310 1320 1330 1340 1350
ADMIHVSEDT FNILKSKYLF EERPDGIIKK RKIKTYFLLR ALTENDPQPE
1360 1370 1380 1390 1400
VKTRSVSVSK SNFGGSLQYN QITPTLNLPV SQLIIKDQNE IKNQNDHDND
1410 1420 1430 1440 1450
DENGNENGNE SSSSNINEEE EDDDNSNNNN NNEDDESSYE DDQEMNQYLN
1460 1470 1480
NSENNKNNNN NSNQINEEDG NWAKNYDGSS ESS
Length:1,483
Mass (Da):167,362
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC80F26D801AED90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti707Q → P in CAB42641 (PubMed:11237875).Curated1
Sequence conflicti765N → NNNN in CAB42641 (PubMed:11237875).Curated1
Sequence conflicti868E → P in CAB42641 (PubMed:11237875).Curated1
Sequence conflicti877L → S in CAB42641 (PubMed:11237875).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ238883 mRNA Translation: CAB42641.1
AAFI02000013 Genomic DNA Translation: EAL69785.1

NCBI Reference Sequences

More...
RefSeqi
XP_643824.1, XM_638732.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL69785; EAL69785; DDB_G0275009

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8619871

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0275009

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238883 mRNA Translation: CAB42641.1
AAFI02000013 Genomic DNA Translation: EAL69785.1
RefSeqiXP_643824.1, XM_638732.1

3D structure databases

SMRiQ553Y7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191309

Proteomic databases

PaxDbiQ553Y7

Genome annotation databases

EnsemblProtistsiEAL69785; EAL69785; DDB_G0275009
GeneIDi8619871
KEGGiddi:DDB_G0275009

Organism-specific databases

dictyBaseiDDB_G0275009, gcA

Phylogenomic databases

eggNOGiKOG1023, Eukaryota
HOGENOMiCLU_249557_0_0_1
InParanoidiQ553Y7
OMAiFRVANMA
PhylomeDBiQ553Y7

Enzyme and pathway databases

ReactomeiR-DDI-2514859, Inactivation, recovery and regulation of the phototransduction cascade
SABIO-RKiQ553Y7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q553Y7

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR029787, Nucleotide_cyclase
PfamiView protein in Pfam
PF00211, Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044, CYCc, 2 hits
SUPFAMiSSF55073, SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS50125, GUANYLATE_CYCLASE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCA_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q553Y7
Secondary accession number(s): Q869Y1, Q9XZS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: August 12, 2020
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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