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Entry version 91 (02 Jun 2021)
Sequence version 2 (19 Oct 2011)
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Protein

Ras guanine nucleotide exchange factor Y

Gene

gefY

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of Ras-bound GDP by GTP.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-193648, NRAGE signals death through JNK
R-DDI-194840, Rho GTPase cycle
R-DDI-354192, Integrin signaling
R-DDI-392517, Rap1 signalling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras guanine nucleotide exchange factor Y
Alternative name(s):
RasGEF domain-containing protein Y
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gefY
Synonyms:rasGEFY
ORF Names:DDB_G0276019
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0276019, gefY

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003844801 – 1508Ras guanine nucleotide exchange factor YAdd BLAST1508

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q552M5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during development; with a peak between 8-12 hours of development.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q552M5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
44689.DDB0238867

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q552M5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1074 – 1234N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST161
Domaini1278 – 1508Ras-GEFPROSITE-ProRule annotationAdd BLAST231

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 73DisorderedSequence analysisAdd BLAST73
Regioni128 – 182DisorderedSequence analysisAdd BLAST55
Regioni197 – 272DisorderedSequence analysisAdd BLAST76
Regioni396 – 517DisorderedSequence analysisAdd BLAST122
Regioni565 – 593DisorderedSequence analysisAdd BLAST29
Regioni606 – 727DisorderedSequence analysisAdd BLAST122
Regioni831 – 1021DisorderedSequence analysisAdd BLAST191
Regioni1153 – 1172DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili659 – 686Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 24Polar residuesSequence analysisAdd BLAST18
Compositional biasi32 – 73Polar residuesSequence analysisAdd BLAST42
Compositional biasi128 – 155Polar residuesSequence analysisAdd BLAST28
Compositional biasi164 – 182Polar residuesSequence analysisAdd BLAST19
Compositional biasi197 – 225Polar residuesSequence analysisAdd BLAST29
Compositional biasi232 – 247Acidic residuesSequence analysisAdd BLAST16
Compositional biasi257 – 272Polar residuesSequence analysisAdd BLAST16
Compositional biasi409 – 462Polar residuesSequence analysisAdd BLAST54
Compositional biasi488 – 508Polar residuesSequence analysisAdd BLAST21
Compositional biasi567 – 593Polar residuesSequence analysisAdd BLAST27
Compositional biasi606 – 694Polar residuesSequence analysisAdd BLAST89
Compositional biasi695 – 726Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi831 – 887Polar residuesSequence analysisAdd BLAST57
Compositional biasi945 – 981Polar residuesSequence analysisAdd BLAST37
Compositional biasi982 – 996Pro residuesSequence analysisAdd BLAST15
Compositional biasi997 – 1021Polar residuesSequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3417, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q552M5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.840.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23113, PTHR23113, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48366, SSF48366, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q552M5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIIIGVKRNI NNSNNSNSNN NSNKKKDKIM SHNNNNTITG KNTNEIMNNN
60 70 80 90 100
NNSNNNNNNN NNNNNNNNNN NNEEVKTEPI QQILKRLNSK NKIEVGATPN
110 120 130 140 150
DIPTSIPSVK NLGKKYDSKA ETHLLNQKVL SSPSKEVNSL KKSTNGTNTI
160 170 180 190 200
PSSSIPSSPP SSPPSSSSLS SDRTSQDIPK SVNGLTASIV AKFSKNIDNN
210 220 230 240 250
TTNNNSNNNN NSSLSTPIQS PRDSLETNPI KDEESEESEE SEESKEEEEE
260 270 280 290 300
LKMGIKTTKT TSETIESSYS TSQLLKNDLI QEKGDDNNNI QEPQQPKYPT
310 320 330 340 350
QTSFITDKSK RLSTPPINGT SISIGNNNNN NNNYINGNSG INTIPRNFQS
360 370 380 390 400
HRVAGDWKDR KLNTLFTQGT VGGNGQNGTV RKNLIGTREL STSSGILQCK
410 420 430 440 450
DDSSSKDQDF EFNNSAGSSG NSSASNSNRN SIAFSSSNHF SSESSQSAPT
460 470 480 490 500
LPIYNPSQYT SPSTPQSPSP SPSPPLISSK SIYINKPPPP HFNQQTNFSV
510 520 530 540 550
SPTKSPSNEK QQQEDEDVKH LVRAFTNRKL NVHHAERKSK ISVQDAEWIV
560 570 580 590 600
KKFFHDTDRQ SKFVLSENRT KDLNQPSSQF SPSTSPSTNS IPTNLLLSNK
610 620 630 640 650
RLSTSLPNIN TNINNSSNNT SSSSSSSSTT SSPSPLTTSS STSVLPPPLS
660 670 680 690 700
SSSSSQLTES LKTRIEENNN NNNNKNINNN NNNNNNNGRN SIHDSQEMTE
710 720 730 740 750
LEDPHSSPSY RHLEEVGKKK YVSAEPSRRP GIKTPLFLNV PTLAMPTQFH
760 770 780 790 800
QIPPERVSSN LFSVSVEENS YPDNPLLFNQ QIINRVANDK DLSYLFFPVL
810 820 830 840 850
KSSTKITSST LNNIIPINKL NNQIHNNNNN NVIISNNTGN NNNNNNSSKN
860 870 880 890 900
NNTVKGNKKQ QNKSSSSSQN NSPPSDFSLS VSPSPCSSLT PSPSPSPSSP
910 920 930 940 950
LIESSMFTKD LSPPPPAAAA IVLQQPVATT NNKSTDKDSR KSLWSSMKSS
960 970 980 990 1000
KPPISTSQPS TIQDTISTSP PSTSTSPTSN SPPTSISPPP PSITTGSSPP
1010 1020 1030 1040 1050
STAGTSPPND NGNNNNNSNK ELTISIPITN VNVHESNIVV ASTPRSGRDL
1060 1070 1080 1090 1100
ATIVAEEFKD RTDIVFCTQH LSMNRIKVRS ASLDAMIDLL TNHRLSQPDL
1110 1120 1130 1140 1150
VESFLLTYKT FTSPLAVLTK LIERYEETDN INNNNNNNND DLIISTRTTA
1160 1170 1180 1190 1200
TITNEDEDNS NSNSNSNKTN KNSSRTIKLG VLSIIKCWVD RHHYDFERNK
1210 1220 1230 1240 1250
ALLSAIVAFL EGPVIDDGME KVSNIILKII DRKANEAEAR RTGTALVMHT
1260 1270 1280 1290 1300
STSHCKFPPS IPPSLSKPDQ IPTLQNFDDL EIARQLTLIE HEAYSMVKPN
1310 1320 1330 1340 1350
ECINLAFSKS DKEIRAPNII NIIKRSNLLP LWVATEIVQE ERLTKRANII
1360 1370 1380 1390 1400
KKFISIADQC KNLNNFNAVM EILSGLNLTP VFRLKKTWET LPRKYLATFR
1410 1420 1430 1440 1450
HLNSLMAPKF NFKVYRDVLH TKNLPCLPFL GVYLTDLTFL EEGSFDQAEN
1460 1470 1480 1490 1500
GLINIVKRTQ IANIIQEIQQ YQQLSYSFAP VPIIKDFLLQ IGGLQERALY

KQSKIIEP
Length:1,508
Mass (Da):166,169
Last modified:October 19, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2DD24E2C3A00128
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAL69466 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000013 Genomic DNA Translation: EAL69466.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
XP_643387.1, XM_638295.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL69466; EAL69466; DDB_G0276019

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8620272

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0276019

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA Translation: EAL69466.1 Sequence problems.
RefSeqiXP_643387.1, XM_638295.1

3D structure databases

SMRiQ552M5
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ552M5, 1 interactor
STRINGi44689.DDB0238867

Proteomic databases

PaxDbiQ552M5

Genome annotation databases

EnsemblProtistsiEAL69466; EAL69466; DDB_G0276019
GeneIDi8620272
KEGGiddi:DDB_G0276019

Organism-specific databases

dictyBaseiDDB_G0276019, gefY

Phylogenomic databases

eggNOGiKOG3417, Eukaryota
InParanoidiQ552M5

Enzyme and pathway databases

ReactomeiR-DDI-193648, NRAGE signals death through JNK
R-DDI-194840, Rho GTPase cycle
R-DDI-354192, Integrin signaling
R-DDI-392517, Rap1 signalling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q552M5

Family and domain databases

CDDicd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
PANTHERiPTHR23113, PTHR23113, 1 hit
PfamiView protein in Pfam
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SUPFAMiSSF48366, SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGEFY_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q552M5
Secondary accession number(s): Q86JC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 19, 2011
Last modified: June 2, 2021
This is version 91 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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