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Entry version 62 (02 Jun 2021)
Sequence version 1 (24 May 2005)
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Protein

WASH complex subunit 2

Gene

washc2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • exocytosis Source: dictyBase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WASH complex subunit 2By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:washc2By similarity
Synonyms:fam21
ORF Names:DDB_G0276221
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0276221, fam21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003883652 – 1479WASH complex subunit 2Add BLAST1478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei535Phosphothreonine1 Publication1
Modified residuei1249Phosphoserine1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q552E2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probable component of the WASH complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0232153

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni188 – 210DisorderedSequence analysisAdd BLAST23
Regioni240 – 564DisorderedSequence analysisAdd BLAST325
Regioni576 – 1383DisorderedSequence analysisAdd BLAST808
Regioni1419 – 1479DisorderedSequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Polar residuesSequence analysisAdd BLAST17
Compositional biasi240 – 280Acidic residuesSequence analysisAdd BLAST41
Compositional biasi285 – 306Polar residuesSequence analysisAdd BLAST22
Compositional biasi307 – 331Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi333 – 347Polar residuesSequence analysisAdd BLAST15
Compositional biasi355 – 385Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi386 – 415Polar residuesSequence analysisAdd BLAST30
Compositional biasi460 – 477Polar residuesSequence analysisAdd BLAST18
Compositional biasi478 – 492Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi515 – 554Polar residuesSequence analysisAdd BLAST40
Compositional biasi596 – 616Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi630 – 647Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi682 – 705Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi711 – 728Polar residuesSequence analysisAdd BLAST18
Compositional biasi735 – 767Polar residuesSequence analysisAdd BLAST33
Compositional biasi768 – 782Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi825 – 889Basic and acidic residuesSequence analysisAdd BLAST65
Compositional biasi901 – 924Polar residuesSequence analysisAdd BLAST24
Compositional biasi937 – 951Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi952 – 974Polar residuesSequence analysisAdd BLAST23
Compositional biasi978 – 993Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1005 – 1044Polar residuesSequence analysisAdd BLAST40
Compositional biasi1059 – 1094Polar residuesSequence analysisAdd BLAST36
Compositional biasi1104 – 1124Polar residuesSequence analysisAdd BLAST21
Compositional biasi1149 – 1191Polar residuesSequence analysisAdd BLAST43
Compositional biasi1217 – 1236Polar residuesSequence analysisAdd BLAST20
Compositional biasi1245 – 1296Polar residuesSequence analysisAdd BLAST52
Compositional biasi1304 – 1323Polar residuesSequence analysisAdd BLAST20
Compositional biasi1329 – 1383Basic and acidic residuesSequence analysisAdd BLAST55
Compositional biasi1419 – 1470Polar residuesSequence analysisAdd BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTIY, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_249774_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q552E2

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIHTIFY

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q552E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEEQPQQQQ QPVREQPSNP DDVPWKKVWT INEMRDSAKD WNLSSDAGLL
60 70 80 90 100
NYMQDFANKL IYKTKELEFQ VDELVKDSKS IHVKVHNTFD QFLMLSNTQF
110 120 130 140 150
IENRVYEDNS ELNNEQNEQT DKPQQQEITE EILIPKFSKA ILIGLEALEK
160 170 180 190 200
ANFVNAALEI SEQSNSNNNN NDYQQQMNGS IAASSAEGGL VEGGEQAGTD
210 220 230 240 250
AQPSANTEKK KEKLDHYLRY PLPHIIGSQQ FHQDDFCGLF IEDSDSDSSD
260 270 280 290 300
EEDEEDVDAE DGSDESSSES SSDDDDEKDE QQQSTLFLTD EQPKQQNFFF
310 320 330 340 350
QDEDATSENN ANKKVSESLF EDEDDIFGDK PVASKKSSNS YTSSLSDILG
360 370 380 390 400
GDDEDDLFGG SKKKQQQQED ADGDEPTKKK DPFADELNNT LSSKNKGGDD
410 420 430 440 450
DLFGGSSSTT TTSKPKKKSM FDDDLFGDSE ETPAPKSSAS RKVTFDDSLF
460 470 480 490 500
GDDETALPTS KKDSTTTSSQ PQQKKTLNDL FTDEDLTPAT KKETKKSSSL
510 520 530 540 550
SFLDGMDEDD LFGTPKPKST TTSAAPTATT TKPPTPIPDS DASGSESTTG
560 570 580 590 600
KSSPAPKKPV GGVKLFDFDA AGGDIFSGKK VGTGGKSSPS PAPKTESKAS
610 620 630 640 650
EDDFFSSDKK STSATKKDAE IFGSEGGLLD VPEKKIKRHD PKKYVDSDVL
660 670 680 690 700
GIDSISSDKN KPKVQDPFGV GAAGSNDDDS FDIPKANSKK EQETKPTKST
710 720 730 740 750
TTDDDLDIPK APTTATTTTT TKPAVKKSTK SNFFDFEDTD SPLSSNKKSG
760 770 780 790 800
GDDDLFSFDS SKTTTETKKQ PITEEPKKKQ DTTTTPSIDP FSGLDIKKPS
810 820 830 840 850
EASISPASPV STIESDPLFG DIKKPVAQKP KKTNFFDGDL TKDEPAKSEP
860 870 880 890 900
TKVEPTKVEP TKAEPTKVEP AKVEPTKVES DKKESNPLGG GDEESVFGDF
910 920 930 940 950
SIKKNPTTSS STTATENKPA VKKSTKSNFF DFEDTDSPLS SNKKNDDDIF
960 970 980 990 1000
SSTTKKSTTT TTTTTSSKDF FGDLDTSSGN KKVEEKKSSD FDSFFSGSDD
1010 1020 1030 1040 1050
PLGITKPKSK TTTTPPLTST TANIESDDPL SLGLPTFTNN NNNNNAKPPP
1060 1070 1080 1090 1100
PPSPLGEDVP SPLTSNNTKN RTKSIGSMFE AQQQLQQQQQ EKNRSESPTS
1110 1120 1130 1140 1150
EKAEPTKKTS NISSLQNKLS LNPNMFLPGS KMPKKKKEES ENEDDSSTNN
1160 1170 1180 1190 1200
DNDSSATDLS DSGRSSPSVT SPTLSGGRPR RNTVSSRNNN DSEESEPVKE
1210 1220 1230 1240 1250
LTHATASRPK SGGRRPPTRK SGTSAPNRSE SPTPTQKSDS ESEKVRSSSP
1260 1270 1280 1290 1300
ITTKPVVSEP TKKTISNTSF FDDIPSEKTS SGKSSPSPTI KSTSEKVTID
1310 1320 1330 1340 1350
PLGDIFASTT TKPTASETKA ALSSAPKKSE PETPKETPKE TPKEKEQTKE
1360 1370 1380 1390 1400
KEQPKETPKT TTTKKSTKAV ETKSETDSFF DDIPDIISRP KASVKSAAAK
1410 1420 1430 1440 1450
KASSTTKPVI SDDIFDDITS TTSKSTTTTT TTTTTKAKST KAVDNLFDDD
1460 1470
TNTTTKATPT KATPSKSKPK AKNVENLFD
Length:1,479
Mass (Da):160,367
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7C7177F5EB19109
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000014 Genomic DNA Translation: EAL69410.1

NCBI Reference Sequences

More...
RefSeqi
XP_643271.1, XM_638179.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL69410; EAL69410; DDB_G0276221

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8620314

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0276221

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000014 Genomic DNA Translation: EAL69410.1
RefSeqiXP_643271.1, XM_638179.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0232153

Proteomic databases

PaxDbiQ552E2

Genome annotation databases

EnsemblProtistsiEAL69410; EAL69410; DDB_G0276221
GeneIDi8620314
KEGGiddi:DDB_G0276221

Organism-specific databases

dictyBaseiDDB_G0276221, fam21

Phylogenomic databases

eggNOGiENOG502QTIY, Eukaryota
HOGENOMiCLU_249774_0_0_1
InParanoidiQ552E2
OMAiRIHTIFY

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q552E2

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWASC2_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q552E2
Secondary accession number(s): Q75JI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 24, 2005
Last modified: June 2, 2021
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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