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Protein

Serine/threonine-protein kinase fray2

Gene

fray2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100ATPPROSITE-ProRule annotationBy similarity1
Active sitei195Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 85ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase fray2By similarityImported (EC:2.7.11.1)
Alternative name(s):
STE20-like kinase fray2By similarity
Gene namesi
Name:fray2Imported
ORF Names:DDB_G0229911
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276577 fray2

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003616511 – 1028Serine/threonine-protein kinase fray2Add BLAST1028

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230Phosphothreonine; by autocatalysisBy similarity1

Post-translational modificationi

Undergoes autophosphorylation in the catalytic domain.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ551H4
PRIDEiQ551H4

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0229911

Structurei

3D structure databases

ProteinModelPortaliQ551H4
SMRiQ551H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 330Protein kinasePROSITE-ProRule annotationAdd BLAST260

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 31Poly-SerSequence analysis4
Compositional biasi35 – 38Poly-SerSequence analysis4
Compositional biasi40 – 51Poly-ThrAdd BLAST12
Compositional biasi398 – 408Poly-ThrAdd BLAST11
Compositional biasi412 – 419Poly-Asn8
Compositional biasi489 – 492Poly-GlnSequence analysis4
Compositional biasi597 – 600Poly-SerSequence analysis4
Compositional biasi624 – 627Poly-GlnSequence analysis4
Compositional biasi717 – 720Poly-Lys4
Compositional biasi721 – 728Poly-Ser8

Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.By similarity1 Publication

Phylogenomic databases

eggNOGiKOG0582 Eukaryota
ENOG410XSWS LUCA
InParanoidiQ551H4
KOiK08835
OMAiETIGKGG

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q551H4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDKYHHDK HHDKHHIDSK QSTAAALSSS STLASSSSMT TTTTTTSTTT
60 70 80 90 100
TAASPITPKP RKNYPNSADQ YELKETIGKG GSGLVQRAIC LPFQENVAIK
110 120 130 140 150
IIDLEHCKNV SLEEIRKEIQ AMSLCHHPNV VAYHTSFVYN ESLWVIMDFL
160 170 180 190 200
SAGSCSDIMR FSFPQGFEEH VIATILKEAL KAICYFHKTG RIHRDIKSGN
210 220 230 240 250
ILIDSNGNIQ LSDFGVSATL IDTGETSRNT FVGTPCWMAP EIMEQVNYDY
260 270 280 290 300
AVDIWSFGIT ALELARGKAP FAEYPPMKVL LLTLQNPPPS LEGDGESKWS
310 320 330 340 350
HSFKDLVEKC LQKDPSKRPL PSKLLEHRFF KQAKKPDYLV QHILAKLPPL
360 370 380 390 400
GQRYQMLSED SFAMLRNTSS PQFDTGHSNS ADEWIFPNEN NDNNNSSTTT
410 420 430 440 450
TTTTTTTTNP SNNNNNNNNK TKENLTQSPF ETPSHTPSTS PGSTPSHSRT
460 470 480 490 500
STPTSNHTAL GSSSTVVPPP VVPLTLPTAI PVTAAAYHQQ QQHHHLSHSS
510 520 530 540 550
GSIPNHNASS NLGASAHSNV HGLAHSSIHP TSSAASTTVV NNTQQPQTLQ
560 570 580 590 600
PPQQQHQLQQ PIKTPSPINA INIVKLNQSD LITPPKTSPK KEGSIPSSSS
610 620 630 640 650
HGNIPSLVTT SPKSPLQHQQ QIPQQQQDPA MINSNNSSIS SNGAYNRELI
660 670 680 690 700
SASGSALSKP PSPSSDKENN STSKSNKSKS RQSSRASSLS ESSDSTSHTS
710 720 730 740 750
SSDEHSSRYE SDRKSYKKKK SSSSSSNSKR DRERERDRDR SNKTYKNSRS
760 770 780 790 800
RNVSRDRERE RDRHNRSRDR DRERERERDR DRERDRDRSR DRSRDRSRDR
810 820 830 840 850
ERDRSRDRSR DRDRSRDRSR DRSRERDRDR SRDRSRDRSR SRDSDSRDRS
860 870 880 890 900
RDRSRSHSNR RRSRSRDSRN KSRDRSSDSD RSRDRSRDRD YKSSKYKKSS
910 920 930 940 950
RGTSGRKNNK IQSKLDSQAT HISYLEDKIS TLTNWLQQQN LLNTSNGQVL
960 970 980 990 1000
SPTDPNLVSK LQTQLDVLQS ENSYLRNENI NLKTIVNGSN STNNSLNQSS
1010 1020
GMAFRNSVSS LHQLNMSNSS NNSRPQTQ
Length:1,028
Mass (Da):115,488
Last modified:May 24, 2005 - v1
Checksum:iE38F2C8AD56063DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000015 Genomic DNA Translation: EAL69242.1
RefSeqiXP_643160.1, XM_638068.1

Genome annotation databases

EnsemblProtistsiEAL69242; EAL69242; DDB_G0276577
GeneIDi8620567
KEGGiddi:DDB_G0276577

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000015 Genomic DNA Translation: EAL69242.1
RefSeqiXP_643160.1, XM_638068.1

3D structure databases

ProteinModelPortaliQ551H4
SMRiQ551H4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0229911

Proteomic databases

PaxDbiQ551H4
PRIDEiQ551H4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL69242; EAL69242; DDB_G0276577
GeneIDi8620567
KEGGiddi:DDB_G0276577

Organism-specific databases

dictyBaseiDDB_G0276577 fray2

Phylogenomic databases

eggNOGiKOG0582 Eukaryota
ENOG410XSWS LUCA
InParanoidiQ551H4
KOiK08835
OMAiETIGKGG

Miscellaneous databases

PROiPR:Q551H4

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRAY2_DICDI
AccessioniPrimary (citable) accession number: Q551H4
Secondary accession number(s): Q869U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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