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Protein

Urease subunit gamma

Gene

ureA

Organism
Streptococcus salivarius (strain 57.I)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ureolysis may allow urea to be employed as a nitrogen source for growth and produces ammonia which may protect from killing at low pH.1 Publication

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Kineticsi

Urea concentrations in the oral cavity of humans normally range from 3 mM to 10 mM.
  1. KM=3.7 mM for urea (at pH 7.0 and 37 degrees Celsius)1 Publication

    pH dependencei

    Optimum pH is 7.0.1 Publication

    Temperature dependencei

    Optimum temperature is 60 degrees Celsius.1 Publication

    Pathwayi: urea degradation

    This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
    Proteins known to be involved in this subpathway in this organism are:
    1. Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC)
    This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionHydrolase

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-184
    SABIO-RKiQ55053
    UniPathwayiUPA00258; UER00370

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urease subunit gammaUniRule annotation (EC:3.5.1.5UniRule annotation)
    Alternative name(s):
    Urea amidohydrolase subunit gammaUniRule annotation
    Gene namesi
    Name:ureAUniRule annotation
    Ordered Locus Names:Ssal_01902
    OrganismiStreptococcus salivarius (strain 57.I)
    Taxonomic identifieri1046629 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    Proteomesi
    • UP000000293 Componenti: Chromosome

    Subcellular locationi

    • Cytoplasm UniRule annotation

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000980501 – 100Urease subunit gammaAdd BLAST100

    Expressioni

    Inductioni

    By low pH and excess glucose.2 Publications

    Interactioni

    Subunit structurei

    Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

    Protein-protein interaction databases

    STRINGi1046629.Ssal_01902

    Structurei

    3D structure databases

    ProteinModelPortaliQ55053
    SMRiQ55053
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the urease gamma subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0831 LUCA
    KOiK01430

    Family and domain databases

    CDDicd00390 Urease_gamma, 1 hit
    Gene3Di3.30.280.10, 1 hit
    HAMAPiMF_00739 Urease_gamma, 1 hit
    InterProiView protein in InterPro
    IPR012010 Urease_gamma
    IPR002026 Urease_gamma/gamma-beta_su
    IPR036463 Urease_gamma_sf
    PANTHERiPTHR45301 PTHR45301, 1 hit
    PfamiView protein in Pfam
    PF00547 Urease_gamma, 1 hit
    PIRSFiPIRSF001223 Urease_gamma, 1 hit
    ProDomiView protein in ProDom or Entries sharing at least one domain
    PD002319 Urease_gamma_reg, 1 hit
    SUPFAMiSSF54111 SSF54111, 1 hit
    TIGRFAMsiTIGR00193 urease_gam, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q55053-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MQLTMREQEK MMISLAAMIA QRRKDKGIKL NHPEAVALIT DYVLEGAREG
    60 70 80 90 100
    KTVAQLMDEA RNLLTREDVM EGIAEMIPMI QVEATFTDST KLVTVHDPIQ
    Length:100
    Mass (Da):11,299
    Last modified:December 14, 2011 - v2
    Checksum:i8F7A87B354FABF7B
    GO

    Sequence cautioni

    The sequence AEJ54138 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti9E → K in AAC43562 (PubMed:8550211).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U35248 Genomic DNA Translation: AAC43562.1
    CP002888 Genomic DNA Translation: AEJ54138.1 Different initiation.
    RefSeqiWP_002886558.1, NC_017594.1

    Genome annotation databases

    EnsemblBacteriaiAEJ54138; AEJ54138; Ssal_01902
    GeneIDi31939497
    KEGGistf:Ssal_01902
    PATRICifig|1046629.4.peg.1688

    Similar proteinsi

    Entry informationi

    Entry nameiURE3_STRE5
    AccessioniPrimary (citable) accession number: Q55053
    Secondary accession number(s): F8HGK2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 14, 2011
    Last modified: May 23, 2018
    This is version 90 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

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