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Entry version 76 (02 Jun 2021)
Sequence version 1 (24 May 2005)
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Protein

Conserved oligomeric Golgi complex subunit 1

Gene

cog1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal Golgi function.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-6807878, COPI-mediated anterograde transport
R-DDI-6811438, Intra-Golgi traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 1
Short name:
COG complex subunit 1
Alternative name(s):
Component of oligomeric Golgi complex 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cog1
ORF Names:DDB_G0277691
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0277691, cog1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003416801 – 1449Conserved oligomeric Golgi complex subunit 1Add BLAST1449

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54ZB3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0237853

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni503 – 529DisorderedSequence analysisAdd BLAST27
Regioni916 – 960DisorderedSequence analysisAdd BLAST45
Regioni1303 – 1338DisorderedSequence analysisAdd BLAST36
Regioni1401 – 1422DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi933 – 960Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2033, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_251438_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54ZB3

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEVIWRS

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033370, COG1

The PANTHER Classification System

More...
PANTHERi
PTHR31658, PTHR31658, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54ZB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFNQMRSSG STTDLNRLNS SSISGGGNIN ISNGGYGNQQ LNAILSPIKS
60 70 80 90 100
SSLSSMSNSS SYSNLNTLSS SKSFNSLTLI ENQNDTTTTT STNNGAISEQ
110 120 130 140 150
YQQLLSMIPK YQTKQYESDV KILFERNTPE QMKQMEFKKR SEIEDMKSQL
160 170 180 190 200
RNLIGNKYRD LVEGSDAIVK MKKSTELISD NLSLMQSELK QFSEKRNHFR
210 220 230 240 250
KGVSQDNLKL NKEKEIQKKI SIFSKYCKFL IDIPEVIWRS LDSNDYFEVC
260 270 280 290 300
VFFLKSKYLY SKITNENNLE IKRLLSKLTI IEKQWISMKQ FPIKTIGYSK
310 320 330 340 350
LFLNESTSRI IGTPIEKYIG SLSTLILFEK KSIKETFNEF LLSRRSVLFN
360 370 380 390 400
SILSKDTNRP IQQTIEKMFQ FLKMSIYYIM VLFYPRKYQT NNNNNNDQPE
410 420 430 440 450
EEEQDDEKLI SNDYQSKISK FKSNLQQYTS SLSSMSSTTT TTNSPTFESK
460 470 480 490 500
MINKPVSEKE LNQLPTLNFT SSILESTFNW RSPYLKECLK FYKDVSNGEL
510 520 530 540 550
SINSSGSQQG DDYQDINTNN NNSNNNNSGI DSQDIEYSLI EFDNFNSNFI
560 570 580 590 600
FKRTSEWIEE IIEDFKLNLV QKFLIDIKSA KELSSLRSEI FDFILDFKNI
610 620 630 640 650
VPFIQPPQTN SLSSSNSSIN SIASPSVSLT SSTSSPIIAT TKATVLTTPT
660 670 680 690 700
PTPTPTPTTP ISWNRMFSII CGKDMKYFLN IFEDIFLVKS ESIIMDSFSR
710 720 730 740 750
INLSKIQSDI FSQIKSEDKN FSEFLWFYNQ DDPIQSIKNK TNGITPSNEL
760 770 780 790 800
FLTKINQLYN NIKSDFIYLL NDNNINNINI NNNNNNNNNN NNNNNNNRSM
810 820 830 840 850
IITSQPKNLI KINEILIKEY MKKSFYKSLN EFTTSTQDRI DQLILLNKNK
860 870 880 890 900
TTSGTTTSTN LKKDEILFIS KLSKIFYKHI VNNPNLYFLN SLNIFDTTNI
910 920 930 940 950
SNCSTSFSKS NSINILDTIS SPPQPPPSPT HSSPSIQRHT NNNNNNNNNN
960 970 980 990 1000
NNTSPIINNN NNNSEILKES LPIIDKLKQQ FYYGCIVWVN EFVGDYSQIL
1010 1020 1030 1040 1050
KQDLFNHDWN DSDRIKTWEK HIIQIESNGH NHNNDANDGG GDDDATVNGV
1060 1070 1080 1090 1100
NEHSTIIYIP YQTSPFITSY LMSISLEISK FSLNTIDKNI LRFIIESITL
1110 1120 1130 1140 1150
NLFNIVNDLL STSSTSTTAS TSNLTSNNTT TTIKFNKEGY IQLLIDLKYI
1160 1170 1180 1190 1200
GFILFGRELN SSSSKKPTSQ PTSNVIIKDS IFKKAKSHYQ SIISTKNNVD
1210 1220 1230 1240 1250
ENIELQKQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQEQ LSNNIVYTFN
1260 1270 1280 1290 1300
QIIELVEKNL DPIDLAFYNS YIVKFIDQTY SKTLTLFGNF VYLHKSIVKP
1310 1320 1330 1340 1350
EKKQSINGGQ QSPPLATTSS NGISGGKGIQ QQQQQQSDLP NPMQLLKTNT
1360 1370 1380 1390 1400
KFQLFSIDTI QTITDAIATA PTTIPSSTSN SIQSSANNSA IASPISTIDY
1410 1420 1430 1440
RNQQQQQQNN TNQQSLPSIL SPTSASSTIN TFSFMGKKIS DLMYNTTKK
Length:1,449
Mass (Da):165,186
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE19BE7468AAEF96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000021 Genomic DNA Translation: EAL68603.1

NCBI Reference Sequences

More...
RefSeqi
XP_642524.1, XM_637432.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL68603; EAL68603; DDB_G0277691

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8621150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0277691

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000021 Genomic DNA Translation: EAL68603.1
RefSeqiXP_642524.1, XM_637432.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0237853

Proteomic databases

PaxDbiQ54ZB3

Genome annotation databases

EnsemblProtistsiEAL68603; EAL68603; DDB_G0277691
GeneIDi8621150
KEGGiddi:DDB_G0277691

Organism-specific databases

dictyBaseiDDB_G0277691, cog1

Phylogenomic databases

eggNOGiKOG2033, Eukaryota
HOGENOMiCLU_251438_0_0_1
InParanoidiQ54ZB3
OMAiPEVIWRS

Enzyme and pathway databases

ReactomeiR-DDI-6807878, COPI-mediated anterograde transport
R-DDI-6811438, Intra-Golgi traffic

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54ZB3

Family and domain databases

InterProiView protein in InterPro
IPR033370, COG1
PANTHERiPTHR31658, PTHR31658, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54ZB3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 24, 2005
Last modified: June 2, 2021
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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