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Protein

CAR1 transcription factor

Gene

CRTF

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear transcription factor with zinc-dependent sequence binding specificity. Required for carA-1 and carA-2 expression in early development. Also required throughout later developmental stages - where it has a cell-autonomous role that is distinct from its capacity to control carA-1 and carA-2 expression. Required for terminal spore differentiation but not essential for cell differentiation and cell sorting. May function to help insulate distinct pathways from simultaneous and universal activation by cAMP.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: dictyBase

GO - Biological processi

  • multicellular organism development Source: dictyBase
  • response to zinc ion Source: dictyBase
  • sorocarp development Source: dictyBase
  • sporulation resulting in formation of a cellular spore Source: dictyBase
  • transcription, DNA-templated Source: dictyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandZinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CAR1 transcription factor
Short name:
CRTF
Alternative name(s):
CAR1-binding factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRTF
ORF Names:DDB_G0278077
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0278077 crtf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Nucleus 2 Publications

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Failure to develop under standard conditions and failure to induce expression of carA-1 and carA-2 early in development. Failure to sporulate, even under conditions that bypass the dependence on early cAMP signaling pathways. Do not form mature spores and all cells of the mutant spore mass are dark in phase with round or irregular shape. These cells are fragile and easily disrupted under a glass cover slip. Very low level of expression of carA-1 and carA-2 with resulting defects in cAMP signaling and thus impaired aggregation, although aggregates develop normally in the presence of a wild-type strain. Post-aggregation and sporulation defects are cell autonomous and independent of carA-1 expression. Early developmental events of CRTF-null strain can be rescued with exogenous cAMP treatment, constitutive carA-1 expression or co-development with wild-type cells; however, these treatments are insufficient to promote sporulation. In shaking culture, null cells grow with the same doubling time as wild-type cells and form normal size growth plaques on bacterial lawns; however, development within these plaques is very poor. When cells are developed directly on solid substrata, development of mutant cells is completely blocked prior to aggregation.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003904071 – 876CAR1 transcription factorAdd BLAST876

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54YU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout development.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by P.aeruginosa, PAO1 strain and PA14 strain infection.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0216392

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni654 – 870Interaction with the carA promoter elementAdd BLAST217

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili483 – 524Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 42Poly-AsnAdd BLAST23
Compositional biasi75 – 80Poly-Asn6
Compositional biasi101 – 115Poly-AsnAdd BLAST15
Compositional biasi138 – 141Poly-Ser4
Compositional biasi156 – 167Poly-AsnAdd BLAST12
Compositional biasi212 – 240Poly-AsnAdd BLAST29
Compositional biasi278 – 284Poly-Asn7
Compositional biasi288 – 292Poly-Asn5
Compositional biasi305 – 324Poly-AsnAdd BLAST20
Compositional biasi325 – 328Poly-Gln4
Compositional biasi362 – 365Poly-Ser4
Compositional biasi375 – 391Poly-AsnAdd BLAST17
Compositional biasi412 – 449Poly-AsnAdd BLAST38
Compositional biasi459 – 477Poly-AsnAdd BLAST19
Compositional biasi493 – 524Poly-GlnAdd BLAST32
Compositional biasi542 – 547Poly-Asn6
Compositional biasi572 – 578Poly-Gln7

Keywords - Domaini

Coiled coil

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54YU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSIEQLYST TQFPSLSSCN TNINNTNNNN NINNINNNTN INTGNLLKNT
60 70 80 90 100
FFKNNIIYNT NNNSINNNSN NNIINNNNNN LLNSNNQNSF QNQNNLNSIH
110 120 130 140 150
NHNNNNNNNN SNNNNTSNSE NLDSLKSALL SSNIFNGSSS SIAHQNLINL
160 170 180 190 200
IISSQNNNNN NGNSNSNTPD QKSTMADILL NSSVPDYFEW CSDIINMPKD
210 220 230 240 250
GNEKSNNSNG GNNNGNNNGN NNNNHNNNNN NNSNNNNNNN SDSVPSPQNN
260 270 280 290 300
YQSPQSDNQS SMVPSFNFSN QNSANSSNNN NNNNGSSNNN NNVRSEPTTP
310 320 330 340 350
NDESNNNSNN TNNNNNNNNN NNNNQQQQLS SNQNSSPLIY SVPSYYVPNY
360 370 380 390 400
GVVLSAPMKG NSSSSILPPQ AWPQNNNNNN GNSNSNNGNN NASGFSDFMF
410 420 430 440 450
NGSNIDYNSI MNNNNNNNNN NNNNNNNNNN NNNNSNNNNN NSNNNNGNNG
460 470 480 490 500
GMFNGGFVNN NNHNNNNNNN NNNGNLNFHN FLQFQNQLQN SNQQQQQQQL
510 520 530 540 550
QQQQQLQQHQ QQQQQLQQQQ LQQQFNIGKP CNINQKKGRG ANNNNNNMPI
560 570 580 590 600
GNQASLVISH PSLKMEGHHH LQQQQQQQHH HQHQQHQQNG NGNNTQIVNS
610 620 630 640 650
AFLDLSSPDS HNQMSPSSPI CLPESPMGAQ HWESGLDPSS LQKQNEINPP
660 670 680 690 700
ISVRSNVVFF EPYLAGEPGR HKACWNLLEP MHRNYYQPIQ FKLPSFPDTS
710 720 730 740 750
LPITQIDDKT GIFDSQRFLA FNNPQAMSKY ESYRIYIHPS LGYSGNAKRF
760 770 780 790 800
KQQPDVNEKA LILDGNVYDG HLNPIYNCKI CTEYYQTKSY FSANPHAKGK
810 820 830 840 850
VLLVKNNILT RVKDGGFTLS LKPMCCSGHN SHIPLYFHFT LTNPLTNEVV
860 870
LQSLINVNVK QWKKSVPNKS KKQRFE
Length:876
Mass (Da):98,085
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FB2B7E1BE65FE10
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000023 Genomic DNA Translation: EAL68211.1

NCBI Reference Sequences

More...
RefSeqi
XP_642106.1, XM_637014.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL68211; EAL68211; DDB_G0278077

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8621317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0278077

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA Translation: EAL68211.1
RefSeqiXP_642106.1, XM_637014.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi44689.DDB0216392

Proteomic databases

PaxDbiQ54YU6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68211; EAL68211; DDB_G0278077
GeneIDi8621317
KEGGiddi:DDB_G0278077

Organism-specific databases

dictyBaseiDDB_G0278077 crtf

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54YU6

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRTF_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54YU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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