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Protein

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Gene

mecr

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69Proton donorBy similarity1
Binding sitei143NADPBy similarity1
Binding sitei343NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 172NADPBy similarity4
Nucleotide bindingi192 – 194NADPBy similarity3
Nucleotide bindingi261 – 264NADPBy similarity4
Nucleotide bindingi286 – 288NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • fatty acid biosynthetic process Source: dictyBase
  • fatty acid metabolic process Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-DDI-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase
Gene namesi
Name:mecr
ORF Names:DDB_G0278095
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278095 mecr

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 14MitochondrionSequence analysisAdd BLAST14
ChainiPRO_000032831915 – 350Enoyl-[acyl-carrier-protein] reductase, mitochondrialAdd BLAST336

Proteomic databases

PaxDbiQ54YT4

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0235198

Structurei

3D structure databases

ProteinModelPortaliQ54YT4
SMRiQ54YT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0025 Eukaryota
COG0604 LUCA
InParanoidiQ54YT4
KOiK07512
OMAiKPKFPAV
PhylomeDBiQ54YT4

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54YT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSTRNIISL VRRYSTSRSV KIASHGSPST ALKIENENIT DKISNKDVLV
60 70 80 90 100
EMLHAPINPA DLNIIQGTYG TNVQVGGVAG MEGVGVVKKV GSGVTGLKEN
110 120 130 140 150
DLVVPSMKQH FGSWRSKGVW SEQQLFKVPS DIPTEYLSTI SINPTTAYLL
160 170 180 190 200
LNDFVKLQQG DVIIQNASNS MVGLSVIQLA KARGIKTINV IRDGSEFEDN
210 220 230 240 250
VQRLKQLGGD IVVSEEYVRT PAFRKLISDL PSPKLALNAV GGQSATELSR
260 270 280 290 300
ILADNGTLVT YGGMSREPVT IPTSQLIFRN IQIRGFWLNK WFEQHTDSEK
310 320 330 340 350
QSVYDAIFDL IRKKQFKLLI EKHKFSEFDQ ALLKSQQSGH GRKIVLDLQL
Length:350
Mass (Da):38,735
Last modified:May 24, 2005 - v1
Checksum:iD68461685025F443
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA Translation: EAL68220.1
RefSeqiXP_642118.1, XM_637026.1

Genome annotation databases

EnsemblProtistsiEAL68220; EAL68220; DDB_G0278095
GeneIDi8621327
KEGGiddi:DDB_G0278095

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA Translation: EAL68220.1
RefSeqiXP_642118.1, XM_637026.1

3D structure databases

ProteinModelPortaliQ54YT4
SMRiQ54YT4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0235198

Proteomic databases

PaxDbiQ54YT4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68220; EAL68220; DDB_G0278095
GeneIDi8621327
KEGGiddi:DDB_G0278095

Organism-specific databases

dictyBaseiDDB_G0278095 mecr

Phylogenomic databases

eggNOGiKOG0025 Eukaryota
COG0604 LUCA
InParanoidiQ54YT4
KOiK07512
OMAiKPKFPAV
PhylomeDBiQ54YT4

Enzyme and pathway databases

ReactomeiR-DDI-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA

Miscellaneous databases

PROiPR:Q54YT4

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMECR_DICDI
AccessioniPrimary (citable) accession number: Q54YT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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