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UniProtKB - Q54YD4 (SYIC_DICDI)
Protein
Probable isoleucine--tRNA ligase, cytoplasmic
Gene
ileS
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Catalytic activityi
- EC:6.1.1.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 607 | ATPBy similarity | 1 |
GO - Molecular functioni
- aminoacyl-tRNA editing activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- isoleucine-tRNA ligase activity Source: dictyBase
- tRNA binding Source: InterPro
GO - Biological processi
- isoleucyl-tRNA aminoacylation Source: GO_Central
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)Alternative name(s): Isoleucyl-tRNA synthetase Short name: IRS Short name: IleRS |
Gene namesi | Name:ileS ORF Names:DDB_G0278293 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0278293, ileS |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: dictyBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000327969 | 1 – 1067 | Probable isoleucine--tRNA ligase, cytoplasmicAdd BLAST | 1067 |
Proteomic databases
PaxDbi | Q54YD4 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 47 – 57 | 'HIGH' regionBy similarityAdd BLAST | 11 | |
Motifi | 604 – 608 | 'KMSKS' regionBy similarity | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
eggNOGi | KOG0434, Eukaryota |
HOGENOMi | CLU_001493_1_1_1 |
InParanoidi | Q54YD4 |
OMAi | KMMAPFT |
PhylomeDBi | Q54YD4 |
Family and domain databases
CDDi | cd07961, Anticodon_Ia_Ile_ABEc, 1 hit |
Gene3Di | 3.40.50.620, 2 hits |
HAMAPi | MF_02003, Ile_tRNA_synth_type2, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002300, aa-tRNA-synth_Ia IPR033709, Anticodon_Ile_ABEc IPR002301, Ile-tRNA-ligase IPR023586, Ile-tRNA-ligase_type2 IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR42780, PTHR42780, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 1 hit |
PRINTSi | PR00984, TRNASYNTHILE |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00392, ileS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54YD4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEVPQKIDF AGEESKILKY WDDIKAFETS VKMSEGKPEY SFYDGPPFAT
60 70 80 90 100
GLPHYGHILA GTIKDTITRY AHQTGHHVER RFGWDCHGLP IEFEIDKLHG
110 120 130 140 150
VRTKEDVLKM GIPTYNQHCR SIVMKYSHEW EIVVNRMGRW IDMKNNYKTM
160 170 180 190 200
DTPFMESVWW VFQELFKKDL VYQGFKVMPY SIGCTTPLSN FEASSNYKDV
210 220 230 240 250
SDPACVVSFQ TLDDEKVSIL AWTTTPWTLP SNLALTVNPK MEYIKINDIK
260 270 280 290 300
RNQIFILGKN RTSILYKSDK EYTVLETMKG TDLIGKKYVP MFPYFASDAN
310 320 330 340 350
MGGFVVIGGD FVTDDSGTGI VHTAPAYGED DFNVCIANGV ISRDQFKRPI
360 370 380 390 400
LNSVDANGCF TSDVTDFAGM MVKDAETTKQ ISIYLKNKGR MVNSANLVHS
410 420 430 440 450
YPYCWRSDTP LIYKAVGSWF VRVESIRDKL LANNDKTYWV PDFVKEKRFA
460 470 480 490 500
NWLKNATDWA VSRNRYWGTP IPLWISEDGE EVVVIGSIDE LERLSGVRVT
510 520 530 540 550
DLHRESIDHI TIPSQKGKGT LRRIEDVFDC WFESGSMPYA QQHYPFENKD
560 570 580 590 600
KFEKIFPAHF IAEGLDQTRG WFYTLLVLST ALFDKPPFQN LIVNGLVLAA
610 620 630 640 650
DGKKMSKRLK NYPDPMEVVS KVGADSLRLY LINSPVVRAE TLKFQEKGVQ
660 670 680 690 700
DMIKDVFLPW FNAYRFFVQN CLRFEKATNT TFQPDIKVAL ASENVMDKWI
710 720 730 740 750
LASCQSLIAF VRAEMAAYRL YTVVPKLVRF IEDLTNWFVR LNRKRLKGSN
760 770 780 790 800
GDADCLAALN ILYEVLMTIC IAMGPFTPFF TEYMYQNLKK ALPKEKQMDS
810 820 830 840 850
VHYVMFPEPI QEAFNTRIEE AISRMQVVIE LGRAARDRRT KPIKFPLKEF
860 870 880 890 900
MVITENQQYL ADLESLKSYI LEELNIQNIV LTSDEGSFVV VTAEADNKRL
910 920 930 940 950
GARLKNDFKK ISPLISKLTN EQLREFQKTQ TIDILGHELT SEDLKIIRKY
960 970 980 990 1000
NGETTNSEPS GNEEILTVLD LTVDSALYEK GLARELINRV QRLRKKSGLT
1010 1020 1030 1040 1050
FDDPVSMFYH TKEAELKTAI ENNNDYIKET ILFNLQFSET TSPSNSFATE
1060
IVSIVKDNDA EIYFLKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000023 Genomic DNA Translation: EAL68319.1 |
RefSeqi | XP_642268.1, XM_637176.1 |
Genome annotation databases
EnsemblProtistsi | EAL68319; EAL68319; DDB_G0278293 |
GeneIDi | 8621477 |
KEGGi | ddi:DDB_G0278293 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000023 Genomic DNA Translation: EAL68319.1 |
RefSeqi | XP_642268.1, XM_637176.1 |
3D structure databases
SMRi | Q54YD4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0231258 |
Proteomic databases
PaxDbi | Q54YD4 |
Genome annotation databases
EnsemblProtistsi | EAL68319; EAL68319; DDB_G0278293 |
GeneIDi | 8621477 |
KEGGi | ddi:DDB_G0278293 |
Organism-specific databases
dictyBasei | DDB_G0278293, ileS |
Phylogenomic databases
eggNOGi | KOG0434, Eukaryota |
HOGENOMi | CLU_001493_1_1_1 |
InParanoidi | Q54YD4 |
OMAi | KMMAPFT |
PhylomeDBi | Q54YD4 |
Miscellaneous databases
PROi | PR:Q54YD4 |
Family and domain databases
CDDi | cd07961, Anticodon_Ia_Ile_ABEc, 1 hit |
Gene3Di | 3.40.50.620, 2 hits |
HAMAPi | MF_02003, Ile_tRNA_synth_type2, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002300, aa-tRNA-synth_Ia IPR033709, Anticodon_Ile_ABEc IPR002301, Ile-tRNA-ligase IPR023586, Ile-tRNA-ligase_type2 IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR42780, PTHR42780, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 1 hit |
PRINTSi | PR00984, TRNASYNTHILE |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00392, ileS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYIC_DICDI | |
Accessioni | Q54YD4Primary (citable) accession number: Q54YD4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families