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UniProtKB - Q54YA0 (ACLY_DICDI)
Protein
Probable ATP-citrate synthase
Gene
acly
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.
By similarityCatalytic activityi
- EC:2.3.3.8
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 245 | MagnesiumBy similarity | 1 | |
Active sitei | 287 | Tele-phosphohistidine intermediateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 228 – 248 | ATPBy similarityAdd BLAST | 21 | |
Nucleotide bindingi | 279 – 305 | ATPBy similarityAdd BLAST | 27 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP citrate synthase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- lipid metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DDI-6798695, Neutrophil degranulation R-DDI-75105, Fatty acyl-CoA biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ATP-citrate synthase (EC:2.3.3.8)Alternative name(s): ATP-citrate (pro-S-)-lyase Citrate cleavage enzyme |
Gene namesi | Name:acly ORF Names:DDB_G0278345 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0278345, acly |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- phagocytic vesicle Source: dictyBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000342146 | 1 – 622 | Probable ATP-citrate synthaseAdd BLAST | 622 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q54YA0 |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 44689.DDB0235360 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 306 – 316 | CoA-bindingSequence analysisAdd BLAST | 11 |
Sequence similaritiesi
In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.Curated
In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.Curated
Phylogenomic databases
eggNOGi | KOG1254, Eukaryota |
HOGENOMi | CLU_006587_4_2_1 |
InParanoidi | Q54YA0 |
OMAi | IHVPDTF |
PhylomeDBi | Q54YA0 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit 3.40.50.261, 1 hit |
InterProi | View protein in InterPro IPR017440, Cit_synth/succinyl-CoA_lig_AS IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR036969, Citrate_synthase_sf IPR033847, Citrt_syn/SCS-alpha_CS IPR005811, CoA_ligase IPR036291, NAD(P)-bd_dom_sf IPR017866, Succ-CoA_synthase_bsu_CS IPR016102, Succinyl-CoA_synth-like |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit PF00549, Ligase_CoA, 1 hit |
SUPFAMi | SSF48256, SSF48256, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01216, SUCCINYL_COA_LIG_1, 1 hit PS00399, SUCCINYL_COA_LIG_2, 1 hit PS01217, SUCCINYL_COA_LIG_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54YA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNSNFNHGN HGSNLPARLF TKQSQALIYN YKEAAVQRML DFDNVSQRDT
60 70 80 90 100
PSVGGLIHPG SDGGMYKAFF GFKELVIPVY NSVSEACQQC PNADVFLNFA
110 120 130 140 150
SHRSAYQSSL LALREPSIQT VVIIAEGVPE NEARSLISIA KKLGKVIIGP
160 170 180 190 200
ATVGGIQAGC FKIGNTAGTI VYIMACKLYR SGSVGFVSKS GGLSNEMYNV
210 220 230 240 250
LSRCTDGIYE GIAIGGDAFP GSTLTDHALR YEKLPEVQMI VILGELGGWD
260 270 280 290 300
EYGIVEALKK GEITKPICAW VSGTVAKIFP TEVQFGHAGA KSGGETESAD
310 320 330 340 350
AKNKALREAG AVVPTSFEDF SNVIAATYAK LQSKGLVKPV EEPTPPELPL
360 370 380 390 400
DFKTAVKAGK VRKPTSIIST ICDDRGDELS YAGVPISEVC KEQYNMGDVI
410 420 430 440 450
GLLWFKRKLP PYASKFFEMC LKLVADHGPC VSGAHNTIVA ARAGKDLVSS
460 470 480 490 500
LVSGLLTIGP RFGGAIDDSA RVFQDAVDNN LQPSQFVEGM KSKGKRIPGI
510 520 530 540 550
GHLIKSADEI DKRVVLLKDY AFTHFSSTKY LEYALEVEKY TLQKANNLIL
560 570 580 590 600
NVDGCIGVLF LDLLHSSGLF TQHEIKEIID VGYLNGFFIV GRSVGLIGHA
610 620
LDQRRNKQGL YRHQADDVHY AL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000023 Genomic DNA Translation: EAL68345.1 |
RefSeqi | XP_642302.1, XM_637210.1 |
Genome annotation databases
EnsemblProtistsi | EAL68345; EAL68345; DDB_G0278345 |
GeneIDi | 8621508 |
KEGGi | ddi:DDB_G0278345 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000023 Genomic DNA Translation: EAL68345.1 |
RefSeqi | XP_642302.1, XM_637210.1 |
3D structure databases
AlphaFoldDBi | Q54YA0 |
SMRi | Q54YA0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0235360 |
Proteomic databases
PaxDbi | Q54YA0 |
Genome annotation databases
EnsemblProtistsi | EAL68345; EAL68345; DDB_G0278345 |
GeneIDi | 8621508 |
KEGGi | ddi:DDB_G0278345 |
Organism-specific databases
dictyBasei | DDB_G0278345, acly |
Phylogenomic databases
eggNOGi | KOG1254, Eukaryota |
HOGENOMi | CLU_006587_4_2_1 |
InParanoidi | Q54YA0 |
OMAi | IHVPDTF |
PhylomeDBi | Q54YA0 |
Enzyme and pathway databases
Reactomei | R-DDI-6798695, Neutrophil degranulation R-DDI-75105, Fatty acyl-CoA biosynthesis |
Miscellaneous databases
PROi | PR:Q54YA0 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit 3.40.50.261, 1 hit |
InterProi | View protein in InterPro IPR017440, Cit_synth/succinyl-CoA_lig_AS IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR036969, Citrate_synthase_sf IPR033847, Citrt_syn/SCS-alpha_CS IPR005811, CoA_ligase IPR036291, NAD(P)-bd_dom_sf IPR017866, Succ-CoA_synthase_bsu_CS IPR016102, Succinyl-CoA_synth-like |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit PF00549, Ligase_CoA, 1 hit |
SUPFAMi | SSF48256, SSF48256, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01216, SUCCINYL_COA_LIG_1, 1 hit PS00399, SUCCINYL_COA_LIG_2, 1 hit PS01217, SUCCINYL_COA_LIG_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACLY_DICDI | |
Accessioni | Q54YA0Primary (citable) accession number: Q54YA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families