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Protein

Basic-leucine zipper transcription factor A

Gene

dimA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator involved in DIF-1 signaling. DIF-1 (Differentiation Inducing Factor-1) is a signal molecule involved in the differentiation of pstO (prestalk-O) cells. Functions as both an activator of prestalk gene expression and repressor of prespore gene expression.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA-binding transcription factor activity Source: InterPro
  • protein heterodimerization activity Source: dictyBase
  • protein homodimerization activity Source: dictyBase
  • sequence-specific DNA binding Source: dictyBase

GO - Biological processi

  • chemotaxis Source: dictyBase
  • programmed cell death Source: dictyBase
  • regulation of cell differentiation Source: dictyBase
  • regulation of transcription, DNA-templated Source: dictyBase
  • sorocarp development Source: dictyBase
  • sorocarp stalk cell differentiation Source: dictyBase
  • sporulation resulting in formation of a cellular spore Source: dictyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDifferentiation, Sporulation, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Basic-leucine zipper transcription factor A
Alternative name(s):
DIF insensitive mutant A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dimA
Synonyms:bzpA
ORF Names:DDB_G0278971
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0278971 dimA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication
  • Note: In response to DIF-1, it accumulates rapidly in the nucleus. Nuclear accumulation is dependent on dimB.

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defective in DIF biosynthesis and in DIF-1-induced stalk-cell differentiation. Exhibits morphological and cell type differentiation defects. DimA and dimB double mutant has the same phenotype.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003286251 – 1230Basic-leucine zipper transcription factor AAdd BLAST1230

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54XG7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Maximum levels of expression in prespore cells, but also expressed in prestalk cells at the slug stage. Developmentally regulated with levels peaking at culmination.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a dimer (By similarity). Heterodimerizes with dimB; in vitro. Also able to form homodimer; in vitro.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0216189

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q54XG7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54XG7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini555 – 618bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni556 – 586Basic motifPROSITE-ProRule annotationAdd BLAST31
Regioni590 – 604Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili728 – 753Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi72 – 105Poly-AsnAdd BLAST34
Compositional biasi200 – 203Poly-Asn4
Compositional biasi209 – 271Poly-GlnAdd BLAST63
Compositional biasi315 – 324Poly-Gln10
Compositional biasi338 – 343Poly-Gln6
Compositional biasi344 – 350Poly-Ala7
Compositional biasi366 – 369Poly-Gln4
Compositional biasi377 – 385Poly-Gln9
Compositional biasi402 – 407Poly-Gln6
Compositional biasi414 – 420Poly-Gln7
Compositional biasi441 – 446Poly-Gln6
Compositional biasi482 – 491Poly-Thr10
Compositional biasi492 – 504Poly-SerAdd BLAST13
Compositional biasi524 – 530Poly-His7
Compositional biasi533 – 537Poly-His5
Compositional biasi833 – 846Poly-HisAdd BLAST14
Compositional biasi1052 – 1148Poly-AsnAdd BLAST97

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54XG7

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYTQARL

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004827 bZIP

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338 BRLZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50217 BZIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54XG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSDNWNFQN NPYFQDYNIG NPNNNTNGIN GSSNGTMNLS NSASLFLNKN
60 70 80 90 100
LGNSDFQPFS LQPSLYLSNS SNNTNNNNNN NNNNNNNNNN NNNNNNNNNN
110 120 130 140 150
NNNNNIINNN TDEFVFKKIS ANNLQTPTSP PKDLGFIQTI LQHQQELFQK
160 170 180 190 200
KLSESGVTNL QPDQIQFMFM QEQQKYLTSL NGNDNTLPPL ENNFSFQHVN
210 220 230 240 250
NNNLTSPPQQ QQQQQQQQQQ QQHQQHQQHQ QHQQQQQQQQ QQQQQQHQHQ
260 270 280 290 300
QQQQQQQQQQ QQQQQQQQQQ QLKQQQPQQH PIQSPQPIQS PTPSPSLQQH
310 320 330 340 350
QTYSYTPSTQ QTSLQQLQQQ QMQQLLQMSP QHQQQHNQIQ QQQAAAAAAA
360 370 380 390 400
LLQQQLAQQQ AQQLAQQQQL AQQQLAQQQQ QQQQQHVQSL HQAQVQQAHM
410 420 430 440 450
SQLQQQQLAQ QAFQQAQQQQ FHQQNIQQHQ NQNQQQLQLP QPQQQQHKST
460 470 480 490 500
PPTQNTPPVK SPAPQTPTLT TNGKGSKSTP PTTTTTTTTT TSSSSSSSSS
510 520 530 540 550
SSSSKKKTSN KKTGNLQVPP TPPHHHHHHH NNHHHHHSEG FSDENDEEFI
560 570 580 590 600
DENEDKSKNK SRSSQNIASR NYRQRKKDHI SEVEFKVQQL SLENERLKQE
610 620 630 640 650
NHLLKKGDLG DVMRPDFDFQ QVLLESQKLM SQLQDAVNKQ DHATIENLLQ
660 670 680 690 700
LYYFASQLRT TVVEREVEKI VHPYTQARLA VMGYRSNAET SILLRPFSTN
710 720 730 740 750
LWWPKYADEV GLTEEQRKAS DILWTDHLKI DMELRTERDQ LDREIKELFL
760 770 780 790 800
KKIVSHGTKR PELLFERETL STFNSESDYP SSPSSASNSS NSPPTSSPTI
810 820 830 840 850
ITPPDSPLTN NQNNQNNNQM INSNSNNSNN NSHHHHHHHH SHLHGHSPYP
860 870 880 890 900
VPNGTVHPPP TTAVSEHNKP IELSELLDVT RKLEMLKKNF VKHRNLICDT
910 920 930 940 950
DLVLSTILTP FQHAKLILRL NSVTCYDFSI VDTITGIWGS INSTLKEGSF
960 970 980 990 1000
IQNLMPDQDG KFEVLEKFKQ NQLLDLKGQR PIKLESLQRT YEKLYQTVLG
1010 1020 1030 1040 1050
SESPNCQFVK QADYQHQNLL TASPNYTNSP LITSSPSQLT PNSPRPPLDI
1060 1070 1080 1090 1100
SNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNSNN
1110 1120 1130 1140 1150
NNNTNNNNNN YNNNGNNNNG NNNNGNNNNG NNGNNGNNSN NSNNGNINSV
1160 1170 1180 1190 1200
DIQALHQQQK QNLQPQQLQQ NQQLQQNQNT PPQQSQQVCS PSSPMTPELN
1210 1220 1230
KQPEIVGGDN TNKKNKSKKY QWYSYKTPNI
Length:1,230
Mass (Da):140,627
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0785C9B5977753B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti365A → T in AAR97288 (PubMed:14729573).Curated1
Sequence conflicti504Missing in AAR97288 (PubMed:14729573).Curated1
Sequence conflicti677 – 680ARLA → VS in AAR97288 (PubMed:14729573).Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY428796 Genomic DNA Translation: AAR97288.1
AAFI02000026 Genomic DNA Translation: EAL67907.2

NCBI Reference Sequences

More...
RefSeqi
XP_641883.2, XM_636791.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL67907; EAL67907; DDB_G0278971

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8621809

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0278971

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY428796 Genomic DNA Translation: AAR97288.1
AAFI02000026 Genomic DNA Translation: EAL67907.2
RefSeqiXP_641883.2, XM_636791.2

3D structure databases

ProteinModelPortaliQ54XG7
SMRiQ54XG7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0216189

Proteomic databases

PaxDbiQ54XG7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL67907; EAL67907; DDB_G0278971
GeneIDi8621809
KEGGiddi:DDB_G0278971

Organism-specific databases

dictyBaseiDDB_G0278971 dimA

Phylogenomic databases

InParanoidiQ54XG7
OMAiPYTQARL

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54XG7

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIMA_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54XG7
Secondary accession number(s): Q6T872
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: November 7, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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