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Entry version 84 (11 Dec 2019)
Sequence version 1 (24 May 2005)
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Protein

26S proteasome non-ATPase regulatory subunit 7

Gene

psmD7

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174113 SCF-beta-TrCP mediated degradation of Emi1
R-DDI-174154 APC/C:Cdc20 mediated degradation of Securin
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DDI-2467813 Separation of Sister Chromatids
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DDI-4641258 Degradation of DVL
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5687128 MAPK6/MAPK4 signaling
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-6798695 Neutrophil degranulation
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M67.973

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 7
Alternative name(s):
26S proteasome regulatory subunit RPN8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:psmD7
ORF Names:DDB_G0279633
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0279633 psmD7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003303271 – 32526S proteasome non-ATPase regulatory subunit 7Add BLAST325

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54WI8

PRoteomics IDEntifications database

More...
PRIDEi
Q54WI8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0232987

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54WI8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 142MPNPROSITE-ProRule annotationAdd BLAST135

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M67A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1556 Eukaryota
COG1310 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54WI8

KEGG Orthology (KO)

More...
KOi
K03038

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKLPVNH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54WI8

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08062 MPN_RPN7_8, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR033858 MPN_RPN7_8
IPR024969 Rpn11/EIF3F_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00232 JAB_MPN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50249 MPN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54WI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTFPTSTIV HPTVLLSVVD HYNRVAKDTN KRVVGALLGS NNKGVVDVSN
60 70 80 90 100
CYGLPFEEDE ANPNIWFLDH NFHENMFAMF KKINARENVV GWYSTGPKIR
110 120 130 140 150
PADQDINELF RRYTPNPVMV IIDVAPKELG IPTKSYVTVE EINKDTSEST
160 170 180 190 200
MRFQHIPSSI DAVEAEEICI EHLLRDVKDS SISSLTTQIT DKKISLKHLL
210 220 230 240 250
TNLQEMQHYL KLVCDGTLPP NHQIIGYIQD IINLSPNLNA NEISKSFAVQ
260 270 280 290 300
NNDTMSVIYL SSMIRSIIAL HNLIINKTAN REAEKKADII NSTPPTTATS
310 320
PSVADKGKEK EQNAFNGADK PSKQA
Length:325
Mass (Da):36,303
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7868280F9AD8866
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000032 Genomic DNA Translation: EAL67591.1

NCBI Reference Sequences

More...
RefSeqi
XP_641565.1, XM_636473.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL67591; EAL67591; DDB_G0279633

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8622140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0279633

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000032 Genomic DNA Translation: EAL67591.1
RefSeqiXP_641565.1, XM_636473.1

3D structure databases

SMRiQ54WI8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232987

Protein family/group databases

MEROPSiM67.973

Proteomic databases

PaxDbiQ54WI8
PRIDEiQ54WI8

Genome annotation databases

EnsemblProtistsiEAL67591; EAL67591; DDB_G0279633
GeneIDi8622140
KEGGiddi:DDB_G0279633

Organism-specific databases

dictyBaseiDDB_G0279633 psmD7

Phylogenomic databases

eggNOGiKOG1556 Eukaryota
COG1310 LUCA
InParanoidiQ54WI8
KOiK03038
OMAiGKLPVNH
PhylomeDBiQ54WI8

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174113 SCF-beta-TrCP mediated degradation of Emi1
R-DDI-174154 APC/C:Cdc20 mediated degradation of Securin
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DDI-2467813 Separation of Sister Chromatids
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DDI-4641258 Degradation of DVL
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5687128 MAPK6/MAPK4 signaling
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-6798695 Neutrophil degranulation
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54WI8

Family and domain databases

CDDicd08062 MPN_RPN7_8, 1 hit
InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR033858 MPN_RPN7_8
IPR024969 Rpn11/EIF3F_C
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSMD7_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54WI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: December 11, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. Peptidase families
    Classification of peptidase families and list of entries
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