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Entry version 65 (16 Oct 2019)
Sequence version 2 (28 Jun 2011)
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Protein

TPR-containing protein DDB_G0280363

Gene

DDB_G0280363

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TPR-containing protein DDB_G0280363
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DDB_G0280363
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0280363

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003524801 – 1304TPR-containing protein DDB_G0280363Add BLAST1304

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54VF4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0206543

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54VF4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati769 – 802TPR 1Add BLAST34
Repeati899 – 932TPR 2Add BLAST34
Repeati978 – 1011TPR 3Add BLAST34
Repeati1046 – 1079TPR 4Add BLAST34
Repeati1084 – 1111TPR 5Add BLAST28
Repeati1112 – 1150TPR 6Add BLAST39
Repeati1152 – 1184TPR 7Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 37Poly-Gln8
Compositional biasi53 – 59Poly-Gln7
Compositional biasi67 – 81Poly-GlnAdd BLAST15
Compositional biasi131 – 142Poly-GlnAdd BLAST12
Compositional biasi147 – 150Poly-Gln4
Compositional biasi153 – 192Asn-richAdd BLAST40
Compositional biasi153 – 192Poly-AsnAdd BLAST40
Compositional biasi307 – 315Poly-Gln9
Compositional biasi333 – 368Poly-GlnAdd BLAST36
Compositional biasi412 – 422Asn-richAdd BLAST11
Compositional biasi412 – 422Poly-AsnAdd BLAST11
Compositional biasi470 – 484Poly-GlnAdd BLAST15
Compositional biasi527 – 539Poly-GlnAdd BLAST13
Compositional biasi549 – 591Poly-GlnAdd BLAST43
Compositional biasi592 – 625His-richAdd BLAST34
Compositional biasi636 – 643Poly-Gln8
Compositional biasi656 – 665Poly-Gln10
Compositional biasi671 – 676Poly-Gln6
Compositional biasi678 – 702Asn-richAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IN7B Eukaryota
ENOG4111FAQ LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54VF4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107 HAT
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386 HAT, 5 hits
SM00028 TPR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54VF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNEDSLSYS FGRMMLNQQQ HHHQQQNNTQ VQQQQQQHTT QFNQVRFGGN
60 70 80 90 100
YHQQHQQQQH HQQQHHQQQQ QQQQQQQQQQ QHPQQYISPT FSYVHNNSNT
110 120 130 140 150
SITHGNLYDI DDNQIDNVNI IRGGNRGYYN QQQQQHQHQQ QQYYHEQQQQ
160 170 180 190 200
HFNINNNNNN SNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNSSLITNSH
210 220 230 240 250
HAQRIVSPIV NGMTSSSGSN MMINDVSFGM NGISSINGIS INNGSGDIDE
260 270 280 290 300
EDDKLLDEQQ QLLQRSLERL SDGEEISFGN PNYFFHPFSE RNINGLPSTN
310 320 330 340 350
SSIVSRQQQL QQQQQKLKLK SSPSPISPFF YTQQQQQQQQ QQQQQQQQQQ
360 370 380 390 400
QQQQQQQQQQ QQQQQQQQNT SINGIIKIDQ TPPTPQYIAN PSVSPLNAPI
410 420 430 440 450
SSPVLGDIYS GNNNNNNINT NNYRQQQKLN TSTGSYQNMS FDAGVNGFNW
460 470 480 490 500
SPSLQPDQST STNHTQAMLQ QQQQRQQQQQ QQTQNLVYLN NQQIKSTVTS
510 520 530 540 550
NRDHWSSVVK PPPIQLQQNS MQQNPIQQQQ QQQQQQQQQS LLQHQQMLQM
560 570 580 590 600
QMQIQQQQQQ QQQQQQQQQQ QQNQQQNQQQ NQQQNQQQNQ QHYPNQHHGQ
610 620 630 640 650
HQHNQHNQHH NQHHNQSHPN HKNQHQKQNQ TQQSTQQQQQ QQQNVQTSTT
660 670 680 690 700
QSPLLQQSQQ PQQQQPPTSN QRQQQQHNNN TNNVTTINNQ TNINIINNDS
710 720 730 740 750
DNEELLTTVN HSKPPPNESK RGELVESPVS KQQYKHFIKQ FKLKEKEGLE
760 770 780 790 800
IAMEFAFQSL SVLPEKVHWR VYLELADLAN RQNNLKLARK FYRKVTSTQP
810 820 830 840 850
YISQGWLEYA KMEEDYGRLE KCQKILQLGL KHCPFNESLL IKGIRHEEKM
860 870 880 890 900
DNLEGARALL SQLRDQSIYK TWRAVMEGGL LEARAGNIDV ARKIFKYLMK
910 920 930 940 950
HVPWYGPIYQ EAYKLEERCE EYERAINIVE KGLFEDPKYG PLWFSALRLY
960 970 980 990 1000
EKTSHGFLQS TRNTVERARQ AVSREVTWKI YFEAAQIEER SKNLTLSRAA
1010 1020 1030 1040 1050
YVKSVELCPE NLLWKVWLGG SRTELNADNI CIARKLVFRA LEEVPSKLRS
1060 1070 1080 1090 1100
LVLLEYSRLE EYAGNINKSR RILKMAHVEA RLDWKVFLES VLLEMRANNY
1110 1120 1130 1140 1150
EAAIKEAKES LKIHSGAGRL WAALIQLNQL KGVKSQLNVF KKALQFVPKS
1160 1170 1180 1190 1200
GEVWCEGARI ALNNNELREA RRFLEFAIQF TPQFGDSFIE LLRLEIMEKG
1210 1220 1230 1240 1250
PNCDISKLEQ LCINADPNYG FMWLHCTVCV LDSSRQVLRN AKKLLLEMTQ
1260 1270 1280 1290 1300
PKEQYLEEKK PEYGSCWVGS DGVLSLNRVF RNDFNNMSNQ EKRKALFGSD

VVKP
Length:1,304
Mass (Da):152,212
Last modified:June 28, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36FFAB1818F89C21
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAL67239 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL67408 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000036 Genomic DNA Translation: EAL67239.1 Sequence problems.
AAFI02000035 Genomic DNA Translation: EAL67408.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
XP_641155.1, XM_636063.1
XP_641400.1, XM_636308.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL67239; EAL67239; DDB_G0280519
EAL67408; EAL67408; DDB_G0280363

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8622534
8622535

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0280363
ddi:DDB_G0280519

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000036 Genomic DNA Translation: EAL67239.1 Sequence problems.
AAFI02000035 Genomic DNA Translation: EAL67408.1 Sequence problems.
RefSeqiXP_641155.1, XM_636063.1
XP_641400.1, XM_636308.1

3D structure databases

SMRiQ54VF4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0206543

Proteomic databases

PaxDbiQ54VF4

Genome annotation databases

EnsemblProtistsiEAL67239; EAL67239; DDB_G0280519
EAL67408; EAL67408; DDB_G0280363
GeneIDi8622534
8622535
KEGGiddi:DDB_G0280363
ddi:DDB_G0280519

Organism-specific databases

dictyBaseiDDB_G0280363

Phylogenomic databases

eggNOGiENOG410IN7B Eukaryota
ENOG4111FAQ LUCA
InParanoidiQ54VF4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54VF4

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00386 HAT, 5 hits
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiY8236_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54VF4
Secondary accession number(s): Q54VF5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 28, 2011
Last modified: October 16, 2019
This is version 65 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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