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UniProtKB - Q54UP5 (XPO4_DICDI)

Entry version 74 (25 May 2022)
Sequence version 1 (24 May 2005)
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Protein

Exportin-4

Gene

xpo4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the nuclear export of proteins (cargos). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor. Xpo4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-4
Short name:
Exp4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xpo4
ORF Names:DDB_G0280907
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...dictyBasei		DDB_G0280907, xpo4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003285381 – 1133Exportin-4Add BLAST1133

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q54UP5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Ran and cargo proteins in a GTP-dependent manner.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		44689.DDB0237580

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q54UP5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q54UP5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4541, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005818_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q54UP5

Identification of Orthologs from Complete Genome Data

More...OMAi		KSISCKS

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q54UP5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR044189, XPO4/7-like

The PANTHER Classification System

More...PANTHERi		PTHR12596, PTHR12596, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54UP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIEFIQNLE KFCIGLQSNK SNERETSEQS ILTLMKTPQP YKLCFNLLSK 
        60         70         80         90        100
SNLTIAHFYG LLMIRDSAIR EWAALDSQTK IMIIETLFQY IENMNSMNFL 
       110        120        130        140        150
NYATKGQSFN TLGVIIKRSW LDNEKYEIGK GQMELNQIVM DRVYQYIDSG 
       160        170        180        190        200
SPDRIEISIK IIGSLIIEFS SSSKAAHIQL SWEFHQKCLI TFQNLHLQPI 
       210        220        230        240        250
FRKVLELLQQ FKDHIQQVPS RLTDQSFLQI LYTSVKVFTD ILDWRFLESG 
       260        270        280        290        300
SSVLAYITSF SGGRTNLKPT IEWISLFTPS QSGGGISPIV SLVFGLYQLV 
       310        320        330        340        350
EKVEKIPNLL RHAMSQLCGL QGPIIKDQKI KNQYLSEVLT FTNKLIEKSI 
       360        370        380        390        400
TTRNWNEMED ISNIIYKFCN TYKFSGIACL PNQIVIPFLQ YTTQFVLSSL 
       410        420        430        440        450
NLMKIWAKHG EEELEEEFEN DCFDILLRSF VSLISDAEML INRKRVDQLE 
       460        470        480        490        500
NFKEQYQVLK QCTSQIYQNY IQSRLELSEI EINKSNEELE PTCKSRGGIG 
       510        520        530        540        550
GAEDEIDEDK KKYDEQLRSV AYIGRLNPGQ SLELLKNEIN RVINSLKERV 
       560        570        580        590        600
SDPILFESLH WLLIFAGHLI FDAENKTPSA IPNAIEDYTF EQCKLTPASQ 
       610        620        630        640        650
VDGVIDLCNA VFRFHMEYEN PLLNNGKMDT ISPLVSQTSL WFTSGWSLVY 
       660        670        680        690        700
LLPSSVFNVQ ISPKIIEAYG TEQPLLSITD YFINKILLNL KCWSGDLDVL 
       710        720        730        740        750
KATSNLLNSF TLNKELCKYL IRSPNWSRLF FLEGISLLPP SVYGQLFKAF 
       760        770        780        790        800
SRVVFSFPLS TRREYFIQLV KTLVEQMDGV LGRADFTKIS QEAKIKENIY 
       810        820        830        840        850
ILLEKLNGIV SVSESEYVDD EDDCLFLTVD LFTKYATSLI AMIPLYDHCN 
       860        870        880        890        900
DIVLLILRLF SNFTKHQLEY LNQDRARSIF PLIIQLFNSV ATTSSHKKTL 
       910        920        930        940        950
DSKEYYHRVR MMVKILTNII TFGDQRNNCP TIISETIFHA INIITPCLSN 
       960        970        980        990       1000
NDLLLYPKLA RNYFMITSFL FGADNIQVKN IPVINTIYSL IEAGILHHDL 
      1010       1020       1030       1040       1050
EIVKSCFECI GCLTKSLENS KEKSGGLVDP HYQSVLIQFI GSVINFLLLQ 
      1060       1070       1080       1090       1100
DFNVDELLSV ASETLFSLMY SSPDGYRSKV IELITRQDPS IQSRVVQQFE 
      1110       1120       1130 
TLTIIGTDRK SKDLFMKNLQ NFLVNVKSLI NKK
Length:1,133
Mass (Da):130,185
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84422A470E155546
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAFI02000039 Genomic DNA Translation: EAL66995.1

NCBI Reference Sequences

More...RefSeqi		XP_640976.1, XM_635884.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		EAL66995; EAL66995; DDB_G0280907

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8622780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ddi:DDB_G0280907

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000039 Genomic DNA Translation: EAL66995.1
RefSeqiXP_640976.1, XM_635884.1

3D structure databases

AlphaFoldDBiQ54UP5
SMRiQ54UP5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0237580

Proteomic databases

PaxDbiQ54UP5

Genome annotation databases

EnsemblProtistsiEAL66995; EAL66995; DDB_G0280907
GeneIDi8622780
KEGGiddi:DDB_G0280907

Organism-specific databases

dictyBaseiDDB_G0280907, xpo4

Phylogenomic databases

eggNOGiKOG4541, Eukaryota
HOGENOMiCLU_005818_0_0_1
InParanoidiQ54UP5
OMAiKSISCKS
PhylomeDBiQ54UP5

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q54UP5

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR044189, XPO4/7-like
PANTHERiPTHR12596, PTHR12596, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPO4_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54UP5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 25, 2022
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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