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Protein

Phospholipase D A

Gene

pldA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by butan-1-ol.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei440PROSITE-ProRule annotation1
Active sitei442PROSITE-ProRule annotation1
Active sitei447PROSITE-ProRule annotation1
Active sitei709PROSITE-ProRule annotation1
Active sitei711PROSITE-ProRule annotation1
Active sitei716PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell motility Source: GO_Central
  • lipid catabolic process Source: UniProtKB-KW
  • phospholipid metabolic process Source: dictyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.4 1939

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-1483166 Synthesis of PA
R-DDI-2029485 Role of phospholipids in phagocytosis
R-DDI-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipase D A (EC:3.1.4.4)
Alternative name(s):
Phosphatase D1
Short name:
PLD 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pldA
Synonyms:pld1
ORF Names:DDB_G0281031
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0281031 pldA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003674701 – 1269Phospholipase D AAdd BLAST1269

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54UK0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed consistently in both vegetative and developing cells.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0231506

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q54UK0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini435 – 462PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini704 – 731PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili131 – 192Sequence analysisAdd BLAST62
Coiled coili803 – 835Sequence analysisAdd BLAST33
Coiled coili1059 – 1096Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi90 – 93Poly-Gly4
Compositional biasi101 – 114Poly-AsnAdd BLAST14
Compositional biasi239 – 242Poly-Asn4
Compositional biasi256 – 268Poly-SerAdd BLAST13
Compositional biasi801 – 819Poly-AsnAdd BLAST19
Compositional biasi822 – 834Poly-AsnAdd BLAST13
Compositional biasi837 – 840Poly-Asn4
Compositional biasi878 – 881Poly-Thr4
Compositional biasi882 – 886Poly-Ala5
Compositional biasi887 – 899Poly-ThrAdd BLAST13
Compositional biasi988 – 991Poly-Pro4
Compositional biasi996 – 1002Poly-Pro7
Compositional biasi1054 – 1060Poly-Thr7
Compositional biasi1062 – 1096Poly-GlnAdd BLAST35
Compositional biasi1099 – 1107Poly-Gln9
Compositional biasi1110 – 1115Poly-Gln6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1329 Eukaryota
COG1502 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54UK0

KEGG Orthology (KO)

More...
KOi
K01115

Identification of Orthologs from Complete Genome Data

More...
OMAi
EVFITAW

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
IPR015679 PLipase_D_fam

The PANTHER Classification System

More...
PANTHERi
PTHR18896 PTHR18896, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00614 PLDc, 1 hit
PF13091 PLDc_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00155 PLDc, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50035 PLD, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54UK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNNSKSPPN EQHQQQPHPP DVLVQLTESF QHFFQSLSPQ YQSMTSLPSI
60 70 80 90 100
NKDSYTSVGS APTTNNNSNS NSNSNSSNRS LNNSGSSNSG GGGSNSNKKV
110 120 130 140 150
NNNNNNNNNN NNNNLQSPTQ SQFPYHYQYS SKALHDFEEK RKLLIEQLKS
160 170 180 190 200
VKINLDTQCD DDPISFIKIR MELTKVKTSL ETELKSLDEL LHTTSEVEEP
210 220 230 240 250
NPTPIDSITS LLTMIMPSSI SNSVTNNTPS SATPLTLSNN NNYTSSSLAT
260 270 280 290 300
SPTTNSSSSS SSSSSSSSTH YYNSSISSNS LSSNLPPSSI PILNTSNNKN
310 320 330 340 350
SYPNSIIPQG TPLDNPDPNL PRFPQRDHIS VKLYVDCDDY FAASAQAIEN
360 370 380 390 400
ATREVFITAW FLSPEVYLIR FPSLDERYRL DNLLKRKAMQ GVKIFIILWD
410 420 430 440 450
ETKIATFKGS KRAKDKLEEL HTNIKVIKHP PIIPIYWSHH QKTLIIDQEI
460 470 480 490 500
AFVGGVDFCF GRFDTWCHHL IDVNSTLWKG KDYYNPILGD MGDILVPFED
510 520 530 540 550
SVDRKKIPRM PWHDVMAGVN GLAARDVALN FILRWNHHKD DYYPQLYFDT
560 570 580 590 600
TPLSPVGTSQ CQLLRSMDEW SGGGRIERSI HTAYVQAIED ANHYIYIENQ
610 620 630 640 650
NFVSTHAPNV WNQISFEIVK RIKRAIRKKE VFRVFIVIPC QQDGKVEETQ
660 670 680 690 700
IKGLMHWQYS TIIRGENTIM KLLRRDCPDV DLTEYICFLS LRTHAFLEGT
710 720 730 740 750
FVTEQIYVHS KLMIVDDRTI IVGSANINDR SLIGERDSEL AFIIRDEIDT
760 770 780 790 800
IQTKMNGQDY IASRLVFNFR LRLWKEHLGL LPQINYPPHD QINNDINNIV
810 820 830 840 850
NLNNNNNSNI NNNINNNNNE INNNNNNNNN NNSNEINNNN SDGILNNSNS
860 870 880 890 900
FHHGSVSDNL PPLNPSSNLN SSNKKLPTTT TAAAAATTTT TTTTTTTTTN
910 920 930 940 950
GTGTTNKQKT SHHRSNSFQG LVLQSPGSNR SNLSSPQDSP QDSPRLKNLA
960 970 980 990 1000
EEISPPPTEQ HQHQSPITDI NLILENVDTI IHSNEQLPPP PSSTTPPPPP
1010 1020 1030 1040 1050
PPLTTTDSVI IEDYKSDGGN LNIENNNSNN TILTNAATSM NNSTSSLSST
1060 1070 1080 1090 1100
SLPTTTTTTT AQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQPSQQ
1110 1120 1130 1140 1150
QQQQQQQLSQ QQQLQIKKKR SSISPSTSSN KLLLSGNGSG DSIRVVTDSG
1160 1170 1180 1190 1200
SSPRGQPRSM SSLHDHADSS YCQKSNIDLI DPTCSDFYFG VWIATAASNT
1210 1220 1230 1240 1250
RIYDTVFPAI PKNSIKTCEQ FAQLQKIPVS LADSKLLSEV RGNLVFHPLD
1260
FLEGEDLQPS FLFTDDLFQ
Length:1,269
Mass (Da):142,142
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF719CC299648C287
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000040 Genomic DNA Translation: EAL66812.1

NCBI Reference Sequences

More...
RefSeqi
XP_640776.1, XM_635684.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL66812; EAL66812; DDB_G0281031

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8622829

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0281031

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000040 Genomic DNA Translation: EAL66812.1
RefSeqiXP_640776.1, XM_635684.1

3D structure databases

ProteinModelPortaliQ54UK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231506

Proteomic databases

PaxDbiQ54UK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66812; EAL66812; DDB_G0281031
GeneIDi8622829
KEGGiddi:DDB_G0281031

Organism-specific databases

dictyBaseiDDB_G0281031 pldA

Phylogenomic databases

eggNOGiKOG1329 Eukaryota
COG1502 LUCA
InParanoidiQ54UK0
KOiK01115
OMAiEVFITAW

Enzyme and pathway databases

BRENDAi3.1.4.4 1939
ReactomeiR-DDI-1483166 Synthesis of PA
R-DDI-2029485 Role of phospholipids in phagocytosis
R-DDI-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54UK0

Family and domain databases

InterProiView protein in InterPro
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
IPR015679 PLipase_D_fam
PANTHERiPTHR18896 PTHR18896, 1 hit
PfamiView protein in Pfam
PF00614 PLDc, 1 hit
PF13091 PLDc_2, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLDA_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54UK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 24, 2005
Last modified: December 5, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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