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Entry version 101 (03 Jul 2019)
Sequence version 2 (02 May 2006)
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Protein

DNA-dependent protein kinase catalytic subunit

Gene

dnapkcs

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Is recruited to DNA ends by the Ku70/Ku80 heterodimer and is involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity). This activity is only apparent when DNA damage is administered in G1 phase of the cell cycle. Required for efficient signaling of DNA double-stranded breaks via phosphorylation of H2AX during G1.By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by wortmannin. Activity of the enzyme seems to be attenuated by autophosphorylation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-5693571 Nonhomologous End-Joining (NHEJ)
R-DDI-8866654 E3 ubiquitin ligases ubiquitinate target proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-dependent protein kinase catalytic subunit (EC:2.7.11.1)
Short name:
DNA-PK catalytic subunit
Short name:
DNA-PKcs
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnapkcs
ORF Names:DDB_G0281167
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0281167 dnapkcs

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Null cells of hatched spores in G1 phase of the cell cycle exhibit a marked increase in sensitivity to bleomycin when compared to parental controls. Consistent with a lack of sensitivity of vegetative null cells to bleomycin H2AX phosphorylation is still apparent in these cells after administration of this agent during vegetative cell growth.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003760021 – 4299DNA-dependent protein kinase catalytic subunitAdd BLAST4299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2789Phosphoserine; by autocatalysisBy similarity1
Modified residuei2814Phosphothreonine; by autocatalysisBy similarity1
Modified residuei2822Phosphothreonine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated upon DNA damage. Could be autophosphorylated. Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair (By similarity).By similarity
Autophosphorylated on Ser-2789, Thr-2814 and Thr-2822. Ser-2789 is a DNA damage-inducible phosphorylation site (inducible with ionizing radiation, IR) (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54UC0

PRoteomics IDEntifications database

More...
PRIDEi
Q54UC0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0229336

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3031 – 3707FATPROSITE-ProRule annotationAdd BLAST677
Domaini3913 – 4245PI3K/PI4KPROSITE-ProRule annotationAdd BLAST333
Domaini4267 – 4299FATCPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili551 – 590Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 34Poly-AsnAdd BLAST12
Compositional biasi561 – 575Poly-AsnAdd BLAST15
Compositional biasi615 – 629Poly-AsnAdd BLAST15
Compositional biasi741 – 746Poly-Gln6
Compositional biasi897 – 900Poly-Gly4
Compositional biasi906 – 909Poly-Ser4
Compositional biasi1210 – 1225Poly-AsnAdd BLAST16
Compositional biasi1427 – 1433Poly-Gln7
Compositional biasi1565 – 1572Poly-Asn8
Compositional biasi1573 – 1576Poly-Ser4
Compositional biasi1694 – 1714Poly-ThrAdd BLAST21
Compositional biasi1715 – 1722Poly-Asn8
Compositional biasi1777 – 1780Poly-Gln4
Compositional biasi2210 – 2213Poly-Asn4
Compositional biasi2368 – 2371Poly-Gly4
Compositional biasi2504 – 2513Poly-Gln10
Compositional biasi2850 – 2862Poly-SerAdd BLAST13
Compositional biasi3072 – 3076Poly-Gln5
Compositional biasi3537 – 3549Poly-SerAdd BLAST13
Compositional biasi3552 – 3558Poly-Ser7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. DNAPK subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0891 Eukaryota
COG5032 LUCA

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q54UC0

KEGG Orthology (KO)

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KOi
K06642

Identification of Orthologs from Complete Genome Data

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OMAi
NYSKCTI

Database for complete collections of gene phylogenies

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PhylomeDBi
Q54UC0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05172 PIKKc_DNA-PK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037706 DNA-PK_dom
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR012582 NUC194
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF08163 NUC194, 1 hit
PF00454 PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM01344 NUC194, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54UC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNIYQRIEN YLIKLFQTIS ETNNNNNNNN TNNNVGIKFE NDLLLVNELG
60 70 80 90 100
SIILKELVLE EEIGLVASLL FTGDHSLLKY LEKSSTISNK ENVKIKVSIL
110 120 130 140 150
NLIAEFIEIL QVRTDDYAIA IKNTCVLVFR KDQSHSVQAA AFGPIKKILH
160 170 180 190 200
LMSRVLKQGS IVAESFGVSE MTQLFLLQFT CGKLTQTVRG EIIVVLGLFT
210 220 230 240 250
EYFSSNMCDR NQQLSFIFME TLGGQLRSKS PESTLIQSCL KGLNSLLVHF
260 270 280 290 300
SGDFIASDPK NVQLIYQYVY ICLDPASSTQ RFEIPRAAMK IVARHAVLLR
310 320 330 340 350
QYLAEHSQPF YTRIEHWCNH INKLNRDIAF TAVDSFFQQI SKELTSGNRS
360 370 380 390 400
LEADQSTFKF FIRKFYSIFE NNNSSRFELS IAIRGCGRFA SPVKSFMGEW
410 420 430 440 450
ELKSLLNSLF KFSEKLMVVK IENIDEITLH LSSFINAFAC ILYELNELEF
460 470 480 490 500
WYLDHIEQVL ETYFIIFPHL FVKSRDRYFK AVNRLISSLF YHGEYLKILL
510 520 530 540 550
SRFVKKGLLI TFSKPNDSIK NLITTANTPF YQVYKDLWYN LLNPTIDTID
560 570 580 590 600
KDLNSTIKKE NNNNNNNKNK NNNNNQTLTK EEISKSIKKL VYDEIVSSIL
610 620 630 640 650
SIIKKLDLQY QKDENDNNSN SNSNNNNNND QDNNKISIIE YESEINQLKP
660 670 680 690 700
VTSKDIELFL GLVEFFKLFI SKYNTELFVQ WIYIFGKEMI SFSKKYPLIS
710 720 730 740 750
GFYKLVQIVM QICKSQKYFN ELQQDDNINS VIFNNQIIDE QLQQQQDIMD
760 770 780 790 800
IDDTDNNSNS NNKINKKLTN SLEEDKNNCF ILFKKYIKEV SNFISHYKDE
810 820 830 840 850
LLSSCIELLL SLPKQLISIP LLVPIANLAF QYGISYLPLA HVGLNAIEYW
860 870 880 890 900
NLVVPDQVHK HLDQLLPSLN DYLKISTNSS DSTSGGDIDI DSGGSMGGGG
910 920 930 940 950
VVPPPSSSSR HRKMKFKSNS SLIDPKQLQF KTSIEDLQNR IIRLLGQLGG
960 970 980 990 1000
DNVHFLGKVS LVGEEIVNGV AWDTEPKVLI KIPFADQNNI DIYLDVILPN
1010 1020 1030 1040 1050
VVNLAEKSPN RQIKVAAGEL LHSVLLMMIG NSANQSQANQ ISYSRLYRKI
1060 1070 1080 1090 1100
FPSLICLSTD VEQVTKQLFQ PLVFQMIHWF TRNKKQESDD TMNLLNAIVD
1110 1120 1130 1140 1150
AVGNPLDGAR RDFAGQCLCE FAKWSLKNTS VKQQEKNAFN FKSILKRIYS
1160 1170 1180 1190 1200
LAHHPDPYKR LGAAISFNQL YRIFREEDSL VDQFIFEILH NIFFSLRIGD
1210 1220 1230 1240 1250
DLTNTSSSKN NSNSNSNNNN NNNNNSEDGT EDSIVEIASK YSNVLAALTK
1260 1270 1280 1290 1300
VIIKRADMLN KPSNTRREHK DLSQFVQWVF QNGCSRTESI VRYESMILFT
1310 1320 1330 1340 1350
QLVTLLPNIK TPLQWVKERI KSNGIQFIVS IAEQQGGGVG GGSSNGNTSL
1360 1370 1380 1390 1400
GRIPKIEIGK HKDIEFWFRN LSTSLNIYLW FFSEGFFEPI QILTSREFKS
1410 1420 1430 1440 1450
SLLSSAFHTF TTQFSMLNFN SNLKTNQQQQ QQQVSMFSSM TPKEIDQFNR
1460 1470 1480 1490 1500
LKCNVITNLF GLYILLLEKY KFEQVIDYGG VAFVQLLVKC LMDPQSVGFV
1510 1520 1530 1540 1550
NNYLEEREVE LSKSSRQDIR NLMSRTFKFP PLLEIINNII KLLIQIKPKY
1560 1570 1580 1590 1600
NDILHKELME YILPNNSNNN NNSSSSGNNK SMFSLIDIRQ LINTEGTDRL
1610 1620 1630 1640 1650
IHLIHSYQIL YKYNLLDSIL LENYNEQSEQ GIQDLPKSSL EFSEFIFDYL
1660 1670 1680 1690 1700
FNNCENLSPS KLLISKELIQ LALTIGIKPI KLLSLIINPN VQNTTTTTTT
1710 1720 1730 1740 1750
TSTTTTTTTT TTSTNNNNDN NNEFIKDIHD IFYKTLFTEI NNYISNNFQL
1760 1770 1780 1790 1800
FLPLLANRII ETNQIHKVLN DVCIMKQQQQ PNRGFKDIIE SIVLFLNSIS
1810 1820 1830 1840 1850
EWTLNSNLKL VEKENIIEFT KNLIKIDPIQ FFENKHCYEF VYNIITNYLC
1860 1870 1880 1890 1900
RSNPLTFKNK VLVLLPYLLS YPKHNNFDLI KQKLNEIVVY DFPLNSKDLT
1910 1920 1930 1940 1950
VKSPIYNEYI TCIERLLETF ELTKNPLVID TLLHVLKETD HTHINYINLS
1960 1970 1980 1990 2000
IERSILSTND IEAKEIFSHC FELFLNHYDE LKITLIDKFC VPLISHMKEN
2010 2020 2030 2040 2050
ILVQIFSQHL SSLMSIIQPL QPKYLSDSQE RKSSIIEKIC CFHLIEALYQ
2060 2070 2080 2090 2100
SLPSAIIKEK INPFFYDKPD GKGTELTAAI MKAAHSAKSE KLTSDDKYVT
2110 2120 2130 2140 2150
RSLCTKYHGA AFSALASVIV STQTKENFFH VFFFKENKDK NEYLWENIID
2160 2170 2180 2190 2200
TDQVFNFQPE TNFLVSYSTP QSLFANDLRY LSSQYLVDSS LSQDFIAKNF
2210 2220 2230 2240 2250
LEGDNNSTTN NNNGDDGIIM QGQSQSGDNE NQISNDIEID QVNSNPSMIA
2260 2270 2280 2290 2300
MLKIIDFYQK KFVVTPPSSI LFGQQSQQPK PTVGDMPKWM FEIYQKLQQG
2310 2320 2330 2340 2350
VHPNIVIFMI KIIINRPQYF ERFHELWIPI LMDYVVSEGN GGNGLHYFVR
2360 2370 2380 2390 2400
DVCFILLKWP NIYKSQDGGG GTTLEKHLSK FVNHLMKNTY CTDRRILKSN
2410 2420 2430 2440 2450
LNIVKSFVER WKSLFKVDKS IILELLSTKG DFKSKSRQIK TTGLVLLSIL
2460 2470 2480 2490 2500
LSNGYPAYDK EYDSNTISEF KFYQVLLDHL QDFKELYDAA SEVCGMILLY
2510 2520 2530 2540 2550
LSKQQQSQQQ QQQSIFPQLL KDKINSILNN NENQRAFSCL YFIGLHYPLF
2560 2570 2580 2590 2600
LQGFYGKIFN LLPQISNETR LIALNIIHWC VEDIQDLYTK LKSNNIENLI
2610 2620 2630 2640 2650
RIREGEIQVV ILRILYKLVQ KRDTTFGTVN QILSLLLSNN WFTSNVTNEY
2660 2670 2680 2690 2700
SRSLYYDIII YIYNNFIEYQ DQSNENSKDL VLSLLIGLSD ESDSINKKLL
2710 2720 2730 2740 2750
QFWDNNSKTL SASSNQRLQQ FFDIMYSPET ESKWVANSCC LLFQLCNRSS
2760 2770 2780 2790 2800
DFTKLLFDKP LSECTFKEVQ VDSSWQHRTL NMNPLFSSSQ YGIDDATTDE
2810 2820 2830 2840 2850
SNGDSMQLDE IRATQAPNFT LTQTAFSEFY PSSSQSYGGT NNNTGSSQLS
2860 2870 2880 2890 2900
SSSSSSGSQS SSQNNSSSKR KQKITNDPKL INNSELRRRF KKIDDRGADE
2910 2920 2930 2940 2950
RIVKFARLQV KRNIEREAYF EKSKQARENQ ITMIRKYRVG ELPDIQIKLQ
2960 2970 2980 2990 3000
DIIKPLQLLC QRDSTIGVNV FSSLFTALYK NTPKESIRTF QCNIKKLIDS
3010 3020 3030 3040 3050
IVERCKFNST LVSSILNISE KNLEFSPEFS KIKDISLNSN NHPMAIILCE
3060 3070 3080 3090 3100
KLILSLQNTT KASTTNQAQK LQQQQQLNQG WDSLRELYKS LKEDDIIMGL
3110 3120 3130 3140 3150
IEKQMGGDIP YTKKALEFEL KGDWVNVLKV YDEATSKLES GELNQYQGNL
3160 3170 3180 3190 3200
SESETALWEN GRLECFTKLC NWSALKDNFN SYYPNPNQIF KEKNCDLLLS
3210 3220 3230 3240 3250
YFFEFNLKVK ENWNYLYQFI ADLANTKQYQ YLENKFPGEL AFLEVTRSDH
3260 3270 3280 3290 3300
NKASYYVSKF YQAFKHQWSS SHPLAIESRH RILQPLQKIV EVEEFLNLTS
3310 3320 3330 3340 3350
TPIINTLKLD TLLTQWKSRF PTKLDDIMVW DDLIFYRSVL LEKIYERFSS
3360 3370 3380 3390 3400
FTSDKSSDEK VKSTLIQERA ILYHKMSKGA RKLGNIVVSE IYFRQAVKSY
3410 3420 3430 3440 3450
PKTKDNDLAF PLVTSLIDIY CTKARNSPSP IETLDRFVKA LKFIESKKDE
3460 3470 3480 3490 3500
ESIINSNENL QKYLMMHGDI FWDIYQLDKK LGSTLVIDSF KKNSLPINLT
3510 3520 3530 3540 3550
SIPINSLKDE LFNSTFKCYS ESIKLHQKST NLLNTTSSSP SLSISSSSSP
3560 3570 3580 3590 3600
YSSTSSSSQP KLSNEILIEK TKTKSAHLKF ANFCDNILKD KISQQTTPTQ
3610 3620 3630 3640 3650
FNEEVIDLAT SVIVSTLEAI KEEIPGSVDK FPRLLEILTQ FEQYSVIARE
3660 3670 3680 3690 3700
FKSRVSTIPC WMFIRWISQM FPYLDLPQGP LILPILLEIA KWYPQAIYFP
3710 3720 3730 3740 3750
FKISSEQFGP LAKKISAPLE KELINPLLDT LVIEFQRLTH PEHRFKDYME
3760 3770 3780 3790 3800
EMKSLIKATP KDLNAIAKLN NEIYDDSFNP STVSGDYNLK FAKEHEASYL
3810 3820 3830 3840 3850
SNFGKDSTKL ARMDQKKFLE IFAEMSGNMN KNMKPNSTAS MKLKDFSGWL
3860 3870 3880 3890 3900
ADFDRSNYQT SHQMEIPGQY DGIGKPQPET HVTISSFDTN VLVMGSLRKP
3910 3920 3930 3940 3950
KRVKIHGNDE LDYPFLIKGG EDLRLDQRIQ QLFGIMNEIL KRDTACNKRS
3960 3970 3980 3990 4000
LNVTTYQVVP MTSKVGIIEW LNDTKPLREI LEEQLAHQLK TPRSNVSISK
4010 4020 4030 4040 4050
LESTKYHNDW INSFAKYLKP NSPVGPLYQQ MFIHATRDDC AKKLEKQHSK
4060 4070 4080 4090 4100
VPENLLQNGI WSLSSSPESY LFIRNSFARS LASFSVCSYV IGIGDRHLEN
4110 4120 4130 4140 4150
FLISQRDGRL IGIDFGHAFG TATQFLPIPE LMPFRLTRQF TSFLRPLDSV
4160 4170 4180 4190 4200
GLLNHNMTYT LTALQNQKEI LLTTMDVFVK EPLLDWSKLA TRLVKEQGKH
4210 4220 4230 4240 4250
PKDTKNVWFP KQKIQIAKKK LELVNPAYIT LEELSGSVHS GLPYEKALSE
4260 4270 4280 4290
IIKGDPKHNI RAKVNKVCSS VKEQIDCLID QSTDPNILSR AWVGWNGAL
Length:4,299
Mass (Da):494,476
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC3B8FF774FE856C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000040 Genomic DNA Translation: EAL66880.2

NCBI Reference Sequences

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RefSeqi
XP_640856.2, XM_635764.2

Genome annotation databases

Ensembl protists genome annotation project

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EnsemblProtistsi
EAL66880; EAL66880; DDB_G0281167

Database of genes from NCBI RefSeq genomes

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GeneIDi
8622912

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ddi:DDB_G0281167

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000040 Genomic DNA Translation: EAL66880.2
RefSeqiXP_640856.2, XM_635764.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0229336

Proteomic databases

PaxDbiQ54UC0
PRIDEiQ54UC0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66880; EAL66880; DDB_G0281167
GeneIDi8622912
KEGGiddi:DDB_G0281167

Organism-specific databases

dictyBaseiDDB_G0281167 dnapkcs

Phylogenomic databases

eggNOGiKOG0891 Eukaryota
COG5032 LUCA
InParanoidiQ54UC0
KOiK06642
OMAiNYSKCTI
PhylomeDBiQ54UC0

Enzyme and pathway databases

ReactomeiR-DDI-5693571 Nonhomologous End-Joining (NHEJ)
R-DDI-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54UC0

Family and domain databases

CDDicd05172 PIKKc_DNA-PK, 1 hit
Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037706 DNA-PK_dom
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR012582 NUC194
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF08163 NUC194, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM01344 NUC194, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRKDC_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54UC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 2, 2006
Last modified: July 3, 2019
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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