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Protein

26S proteasome non-ATPase regulatory subunit 11

Gene

psmD11

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmD11 is required for proteasome assembly (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-6798695 Neutrophil degranulation
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 11
Alternative name(s):
26S proteasome regulatory subunit RPN6
26S proteasome regulatory subunit S9
Gene namesi
Name:psmD11
ORF Names:DDB_G0281315
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0281315 psmD11

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003274591 – 41326S proteasome non-ATPase regulatory subunit 11Add BLAST413

Proteomic databases

PaxDbiQ54UB5

Interactioni

Subunit structurei

Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0232994

Structurei

3D structure databases

SMRiQ54UB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 383PCIPROSITE-ProRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the proteasome subunit S9 family.Curated

Phylogenomic databases

eggNOGiKOG1463 Eukaryota
COG5159 LUCA
InParanoidiQ54UB5
KOiK03036
OMAiKDFNTAF
PhylomeDBiQ54UB5

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR011990 TPR-like_helical_dom_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q54UB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNWKEQLEEI GNCQDSNKAI QDYNKILTIQ ESPDDIKEEA ILRLAKLFVK
60 70 80 90 100
IGKGDQLPTL LRSVRPFFDK ISKPKTDKIV RNFIDIFSTV PDNLTTLIEF
110 120 130 140 150
VKENIQWCKD TNRIYLRQRL ETKLFTLMFE AKDYANALSG LTTLLTEIKR
160 170 180 190 200
LDDKPLLVEI QLVESRIQHA LKNIPKARAA LTSARTNANT IYCPPKLQAE
210 220 230 240 250
IDMQSGILHS EEKDYKTAFS YFFESYETYD SLEDPFAMKA LKYMLLCKIM
260 270 280 290 300
TNQTDDVHAL VNGKIGLKYH NNRSIEAITQ ISKSHAKRSL HMFQEVTKEF
310 320 330 340 350
SDQLSDDPII HSHLTELYSN LLEQNLCRII EPFSRVEISH IAKLIDLPVD
360 370 380 390 400
VVERKLSLMI LDKKYNGILD QGTGTLIVFE EQKEDKLFNC SLETIGALSR
410
VVDLLYEKTN KLS
Length:413
Mass (Da):47,618
Last modified:May 24, 2005 - v1
Checksum:i95082D15D15A241F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000040 Genomic DNA Translation: EAL66954.1
RefSeqiXP_640861.1, XM_635769.1

Genome annotation databases

EnsemblProtistsiEAL66954; EAL66954; DDB_G0281315
GeneIDi8622917
KEGGiddi:DDB_G0281315

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000040 Genomic DNA Translation: EAL66954.1
RefSeqiXP_640861.1, XM_635769.1

3D structure databases

SMRiQ54UB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232994

Proteomic databases

PaxDbiQ54UB5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66954; EAL66954; DDB_G0281315
GeneIDi8622917
KEGGiddi:DDB_G0281315

Organism-specific databases

dictyBaseiDDB_G0281315 psmD11

Phylogenomic databases

eggNOGiKOG1463 Eukaryota
COG5159 LUCA
InParanoidiQ54UB5
KOiK03036
OMAiKDFNTAF
PhylomeDBiQ54UB5

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-6798695 Neutrophil degranulation
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q54UB5

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR011990 TPR-like_helical_dom_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSD11_DICDI
AccessioniPrimary (citable) accession number: Q54UB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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