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Entry version 97 (16 Oct 2019)
Sequence version 1 (24 May 2005)
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Protein

ABC transporter C family member 12

Gene

abcC12

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi464 – 471ATPPROSITE-ProRule annotation8
Nucleotide bindingi1081 – 1088ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DDI-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter C family member 12
Alternative name(s):
ABC transporter ABCC.12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:abcC12
ORF Names:DDB_G0280973
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0280973 abcC12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei152 – 172HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei227 – 247HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei252 – 272HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei338 – 358HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei375 – 395HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei712 – 732HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei772 – 792HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei840 – 860HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei862 – 882HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei952 – 972HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003638561 – 1323ABC transporter C family member 12Add BLAST1323

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54U44

PRoteomics IDEntifications database

More...
PRIDEi
Q54U44

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54U44

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 396ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST287
Domaini428 – 652ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini720 – 1010ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST291
Domaini1047 – 1281ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi662 – 669Poly-Asp8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54U44

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANTVVLW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54U44

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54U44-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDIELNSVD NLETKGGKEI KKKEKKIGYG GKKSPEENSN FLSNLTFSWA
60 70 80 90 100
DGFVIHCFRN VLQLSHLWDL ASYDKSEYLA KKIAKSWEIE IQKPKPSYLR
110 120 130 140 150
AGFRAFGKLH CISLFFYSIY VGSQFVGPEI LSRMVTFVVE SKLGTSTEDP
160 170 180 190 200
NMGYYYALIM FGTAMIGSFC NYQANRVTVR TGDRLRSIIV LDVYKKAIKL
210 220 230 240 250
SNSARSNTSP GQIVNLISND AQRMIEVFGI LNNGLFALPQ IIICLALLYE
260 270 280 290 300
KIGWPTFVGL GLMLAAIPFN GLAAKKLTET RRILIGHTDG RVKVTSEILQ
310 320 330 340 350
AMKIIKLYAW EDSFAKKVLD RRNNEIKLLF SFTRYRTILI AMIGAIPTAA
360 370 380 390 400
SILVFSTYYG YNGSLDAGKI FSALSYLNLL KIPLGFLPIL IALGIQMQIA
410 420 430 440 450
SKRVTDFLLL PEMKEVQQID NPSLPNGVYM KNSTTTWNKE KEDSFGLKNI
460 470 480 490 500
NFEAKGQSLT MVVGSVGSGK STLVQAMLGE LETIDGEIGI KGSIAYVPQQ
510 520 530 540 550
AWIINATLKE NIIFGKELDE ERYQKVLEVC ALKRDIELFP QGDSVEIGER
560 570 580 590 600
GINLSGGQKQ RVSIARAVYS DADVYILDDP LSAVDSHVGK HLFHKCFKGI
610 620 630 640 650
LSSKTVILVA NQINYLPFAD NTVVLKSGEI VERGTYYELI NAKLEFASLL
660 670 680 690 700
QEYGVDENTK GDDSDDDDDK KDDDKKEEKV EKPKQSDKDG TLISEEEAEQ
710 720 730 740 750
GAVAGKVYWK YVTAGGGLLF LFAMILFLLE TGSKTFTDWW LSHWQTESSE
760 770 780 790 800
RMESILLGEE PTGLTDDQNL GIYIGVGMAS IIVTVVRTFS FFEYAVRAAH
810 820 830 840 850
SIHHELFNAL LKKPMSFFDQ TPLGRIINRF TRDLDIIDNL IATSIAQFFT
860 870 880 890 900
LMLSVLATLI LISIIVPWLL IPLAPICILF FILQYFYRYT SRGLQRIEAI
910 920 930 940 950
TRSPIFNHFS ETLNGVVSIR AYKKQQENIL KNQKRLDDNN NCYLTLQAMN
960 970 980 990 1000
RWLGLRLDFL GNLIVFFSCI FITLKKDTIS PSDVGLVLSY ALSITSNLNQ
1010 1020 1030 1040 1050
GVLQAADTET KMNSVERISQ YIRGAVEAPQ IIDDCRPSPD WPINGSIKFD
1060 1070 1080 1090 1100
NLVMRYREGL DPVLKGITCE IKAKEKIGIV GRTGAGKSSI VLALFRLIEA
1110 1120 1130 1140 1150
SEGSISIDGE NIAKFGLKDL RRNLAIIPQD PVLFSGTLRE NLDPFNECPD
1160 1170 1180 1190 1200
HELWSILDDI QLSKVFKSTE EGLNSKVTEN GENFSVGQRQ LIVLARALLR
1210 1220 1230 1240 1250
KPKILVLDEA TASVDGQSDS LIQATIRNKF SNCTILTIAH RLNTIMDSDK
1260 1270 1280 1290 1300
IMVLDAGKIS EFDEPWTLLQ NQNGLLTWLV NETGPQNAIY LRKLAEAKKS
1310 1320
GLNINEITQI DQQNDNLNTP PRL
Length:1,323
Mass (Da):148,126
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i338966DE25C8F404
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10 – 19DNLETKGGKE → EIWKLREER in AAL85715 (PubMed:12456012).Curated10
Sequence conflicti829R → C in AAL85715 (PubMed:12456012).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000040 Genomic DNA Translation: EAL66783.1
AF474344 Genomic DNA Translation: AAL85715.1

NCBI Reference Sequences

More...
RefSeqi
XP_640932.1, XM_635840.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL66783; EAL66783; DDB_G0280973

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8622995

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0280973

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000040 Genomic DNA Translation: EAL66783.1
AF474344 Genomic DNA Translation: AAL85715.1
RefSeqiXP_640932.1, XM_635840.1

3D structure databases

SMRiQ54U44
ModBaseiSearch...

Proteomic databases

PaxDbiQ54U44
PRIDEiQ54U44

Genome annotation databases

EnsemblProtistsiEAL66783; EAL66783; DDB_G0280973
GeneIDi8622995
KEGGiddi:DDB_G0280973

Organism-specific databases

dictyBaseiDDB_G0280973 abcC12

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
InParanoidiQ54U44
OMAiANTVVLW
PhylomeDBiQ54U44

Enzyme and pathway databases

ReactomeiR-DDI-382556 ABC-family proteins mediated transport
R-DDI-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DDI-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54U44

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCCC_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54U44
Secondary accession number(s): Q8T6G8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: October 16, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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