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Protein

Probable serine/threonine-protein kinase pdkA

Gene

pdkA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98ATPBy similarity1
Binding sitei153ATPBy similarity1
Active sitei192Proton acceptorPROSITE-ProRule annotation1
Binding sitei196ATP; via carbonyl oxygenBy similarity1
Binding sitei210ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 81ATPBy similarity3
Nucleotide bindingi147 – 149ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-114604 GPVI-mediated activation cascade
R-DDI-1257604 PIP3 activates AKT signaling
R-DDI-165158 Activation of AKT2
R-DDI-202424 Downstream TCR signaling
R-DDI-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-DDI-389357 CD28 dependent PI3K/Akt signaling
R-DDI-392451 G beta:gamma signalling through PI3Kgamma
R-DDI-444257 RSK activation
R-DDI-5218920 VEGFR2 mediated vascular permeability
R-DDI-5218921 VEGFR2 mediated cell proliferation
R-DDI-5625740 RHO GTPases activate PKNs

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase pdkA (EC:2.7.11.1)
Alternative name(s):
3-phosphoinositide-dependent protein kinase A
Pdk-class protein kinase A
Gene namesi
Name:pdkA
ORF Names:DDB_G0281471
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0281471 pdkA

Subcellular locationi

GO - Cellular componenti

  • intracellular vesicle Source: dictyBase
  • plasma membrane Source: dictyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003588901 – 686Probable serine/threonine-protein kinase pdkAAdd BLAST686

Proteomic databases

PaxDbiQ54TW2
PRIDEiQ54TW2

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0216243

Structurei

3D structure databases

ProteinModelPortaliQ54TW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 449Protein kinasePROSITE-ProRule annotationAdd BLAST381
Domaini593 – 682PHAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 144PIF-pocketBy similarityAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 16Poly-Gly6
Compositional biasi28 – 34Poly-Thr7
Compositional biasi224 – 235Poly-GlnAdd BLAST12
Compositional biasi262 – 265Poly-Gln4
Compositional biasi288 – 292Poly-Thr5
Compositional biasi293 – 308Poly-AsnAdd BLAST16
Compositional biasi463 – 466Poly-Pro4
Compositional biasi506 – 523Poly-AsnAdd BLAST18
Compositional biasi554 – 560Poly-Ser7

Domaini

The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0592 Eukaryota
ENOG410XQ0C LUCA
InParanoidiQ54TW2
KOiK06276
OMAiIPWSLEL
PhylomeDBiQ54TW2

Family and domain databases

CDDicd01262 PH_PDK1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR033931 PDK1-typ_PH
IPR039046 PDPK1
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24356:SF163 PTHR24356:SF163, 1 hit
PfamiView protein in Pfam
PF14593 PH_3, 1 hit
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q54TW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENIVITNTS GGGGGGVPSS STDPPNNTTT TTATASAIDL NMSLSPFLSS
60 70 80 90 100
PSLSSPSIQS AKKKTIEDFI IGKVLGEGSY GAVVLGTEKE TQQQYAIKIL
110 120 130 140 150
EKKQIIKENK IKYVQIEKEI FCKSNHPNIV KLFFTFRSEQ CLYYVLELCS
160 170 180 190 200
QGDLLHQIKK VGSFDYRSCQ YYVAEIISGL EHLHSLGIVH RDLKPENILM
210 220 230 240 250
SSDLHVKITD FGTGKILPPP QSSQQQQQQQ QQQQQLPTNS SGNLSSLLNN
260 270 280 290 300
VNNLSVSTDL TQQQQNRTSS VDSASTTDSM ISPNLQPTTT TTNNNNNNNN
310 320 330 340 350
NNNNNNNNTA AGSNTNTNTN TNINTNINAN INNIKTTEIP KLTRNNSFVG
360 370 380 390 400
TAEYVSPELI SNKETSTDSD LWALGCIIYQ MASGRVPFRG KTEFLTFQKV
410 420 430 440 450
SNRELVYPIN MNPVIKDLVE KLLVIKPTDR LGSSSTPGGF DNLKAHPFFQ
460 470 480 490 500
DFNWSSLSNM SHPPPPIQPP QEKIIFDGDE LFSPSLDCTT PRNNNVDENH
510 520 530 540 550
QQNSCNNNNN NNNNINNINN NNNSSSNNIS NSNSNSNSSN NLNISNGNLS
560 570 580 590 600
TPRSSSSSSS QQPTQRSGSS GGSRDGGSSS NNISKWLNNG ENVIYQGLVW
610 620 630 640 650
KRKGFSIKKR QLILTDTPRL IYIDPKKMEL KGEIPWSDSI KPKLKSNNNF
660 670 680
VIKTPKRKYL LEDVAHNPQK WVDSIKSVIL SSGSSN
Length:686
Mass (Da):75,562
Last modified:May 24, 2005 - v1
Checksum:iC4FCC7FE8539A842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000041 Genomic DNA Translation: EAL66717.1
RefSeqiXP_640699.1, XM_635607.1

Genome annotation databases

EnsemblProtistsiEAL66717; EAL66717; DDB_G0281471
GeneIDi8623085
KEGGiddi:DDB_G0281471

Entry informationi

Entry nameiPDPKA_DICDI
AccessioniPrimary (citable) accession number: Q54TW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 24, 2005
Last modified: July 18, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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