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Entry version 106 (22 Apr 2020)
Sequence version 1 (24 May 2005)
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Protein

ABC transporter G family member 5

Gene

abcG5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi168 – 175ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi935 – 942ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter G family member 5
Alternative name(s):
ABC transporter ABCG.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:abcG5
ORF Names:DDB_G0281391
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0281391 abcG5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Transmembranei557 – 577HelicalSequence analysisAdd BLAST21
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Transmembranei616 – 636HelicalSequence analysisAdd BLAST21
Transmembranei643 – 663HelicalSequence analysisAdd BLAST21
Transmembranei725 – 745HelicalSequence analysisAdd BLAST21
Transmembranei1236 – 1256HelicalSequence analysisAdd BLAST21
Transmembranei1271 – 1291HelicalSequence analysisAdd BLAST21
Transmembranei1320 – 1340HelicalSequence analysisAdd BLAST21
Transmembranei1352 – 1372HelicalSequence analysisAdd BLAST21
Transmembranei1379 – 1399HelicalSequence analysisAdd BLAST21
Transmembranei1481 – 1501HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003303631 – 1509ABC transporter G family member 5Add BLAST1509

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54TV2

PRoteomics IDEntifications database

More...
PRIDEi
Q54TV2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0215344

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54TV2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 376ABC transporter 1PROSITE-ProRule annotationAdd BLAST248
Domaini472 – 748ABC transmembrane type-2 1Add BLAST277
Domaini888 – 1141ABC transporter 2PROSITE-ProRule annotationAdd BLAST254
Domaini1231 – 1504ABC transmembrane type-2 2Add BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 66Asn-richAdd BLAST46
Compositional biasi760 – 767Poly-Lys8
Compositional biasi818 – 824Poly-Asn7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0065 Eukaryota
COG0842 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_35_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54TV2

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMNGIYM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54TV2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03232 ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR013581 PDR_assoc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF08370 PDR_assoc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54TV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKQDPRDKS SYSPNLSIPI NNQEEPTLNN NNNNNNNNNN NNNNNNNNNN
60 70 80 90 100
NNNNNNNNNK NNNNNNIKHK DEENDFEDSI YQIAKEHEGE EDDEYFPIPL
110 120 130 140 150
DELMPNHEND ELTKKIKQTR PEDKTGLYVY CRNATYTVKH RENKKVKIKL
160 170 180 190 200
LDDVSFFLRP KQMTLILGTP GCGKSTIFQM LAGQLKDKHF EGELLFNGHP
210 220 230 240 250
INHKNHHRDI SYVTQDDIHV PTLTVKETFR FALDCLGKKE LTREEKQVSV
260 270 280 290 300
DNCMKLLGLK HAENTLVGDN FIRGISGGQK KRVTIGVGVI KGSNLLLMDE
310 320 330 340 350
PTSGLDSSTS FEILSDVKKF VTYGYSPALI TLLQPSVQLT SLFDNLMIMS
360 370 380 390 400
KGKICYFGPM NRALGYFKKL GFACPSHNNP AEFFQEVVDA PERYSFIHPP
410 420 430 440 450
KCKTSDDFVK AYRESDIYLE LMEKMDANKD GIVDDNKPKV LVDSTAKELG
460 470 480 490 500
MYPHGIGYQT KICLKRGFIM ISRNYYNFAT RVFKGIFFGL LLGTLYWRIG
510 520 530 540 550
HNQSGGMERF GLLFFIMTTI IFSSFAAVNS FFGERKVFYS QKALHYYKTG
560 570 580 590 600
AYFISSIICD IPAGLIEVAF FGPIVYWLAN LRPVFIRFVY FMILLFITDN
610 620 630 640 650
LSLSFAKMCA AISPTIEIAN VTASVILSIW LLFSGFTAPK NDIGGWWIWL
660 670 680 690 700
YYISPYTWIF QGLSINEFTY QAYGCKDSEL IPPRTPQNLL PYPEGFGGNQ
710 720 730 740 750
VCQYTSGEQI MDAFGINNPD YFKWIVYAIL GAYIVFFYSV CFFALKYLNF
760 770 780 790 800
EDKKSKLAVK KLKKKKKVIV CKEDEEPNCK VTTEALERVS DDNDDNADIS
810 820 830 840 850
NYDDDTVIDM KSPLTSPNYN NNNNLSGSGN NIKRRKVKTP STLSPMVNSP
860 870 880 890 900
LTNLSPMVNT PSKNGNHSKQ KPISTSQKDI SSETGSYLQF KKLCYAVDVK
910 920 930 940 950
ADDPDNPKKK KSQRLQLLTD IDGYVKPGQM LALMGPSGAG KSTLLDVLAQ
960 970 980 990 1000
RKTGGHITGE ILINGKPPSE FTNRIRAYVE QMDVLPPTQT VREAIAFSAR
1010 1020 1030 1040 1050
CRLPPEVTKE EREIFVDKIV EVLSLSSIKD LKIGVLGNGL SVSQRKRVNI
1060 1070 1080 1090 1100
GVELASNPEI LFLDEPTSGL DSGDAFKVID VVNKIAKVMN RTVICTVHQP
1110 1120 1130 1140 1150
SAAIFEFFDQ LLLLKKGGET IYFGPLGNQS SVILDYCDKL GMHIKPHINP
1160 1170 1180 1190 1200
ADFVMTLADE GKMVEGPNGE QEHLDAKKAY FESNICKKEY EIMEGQLIPD
1210 1220 1230 1240 1250
DFVVKTYDSR FASSWMTQFR ALCMRSWLSR LRRPAIFVSN CLRSILLAVL
1260 1270 1280 1290 1300
LGTLFVRMDY EQKDARSRVS LLFFSFLFAG MVAIGNIPTT VLERGVFYRE
1310 1320 1330 1340 1350
VTAGFYHSTA YMISYVLTSY PFILSTGILY IIPTFWIAGL DSGRHSSKFW
1360 1370 1380 1390 1400
YCLFIFIITY IMYDAFALCL AVCLPNEVMA STICGIGLSL ATLFGGFVIA
1410 1420 1430 1440 1450
RPNYPSAYYW CHYLDWLRYP LEASCTNEFT GLTFVCTNNK GAVPIPIIEN
1460 1470 1480 1490 1500
GVQIAIKYYC PITNGDDFML TYGFHKFMRY IDIAAIFGYI FIFVGLSFWG

FKKVRWLNR
Length:1,509
Mass (Da):170,937
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6AA767896850909
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137T → P in AAL91490 (PubMed:12456012).Curated1
Sequence conflicti510F → L in AAL91490 (PubMed:12456012).Curated1
Sequence conflicti1160E → Q in AAL91490 (PubMed:12456012).Curated1
Sequence conflicti1172 – 1173EH → VP in AAL91490 (PubMed:12456012).Curated2
Sequence conflicti1184N → D in AAL91490 (PubMed:12456012).Curated1
Sequence conflicti1204V → I in AAL91490 (PubMed:12456012).Curated1
Sequence conflicti1504V → I in AAL91490 (PubMed:12456012).Curated1
Sequence conflicti1507L → F in AAL91490 (PubMed:12456012).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF482384 Genomic DNA Translation: AAL91490.1
AAFI02000041 Genomic DNA Translation: EAL66677.1

NCBI Reference Sequences

More...
RefSeqi
XP_640709.1, XM_635617.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL66677; EAL66677; DDB_G0281391

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8623096

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0281391

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482384 Genomic DNA Translation: AAL91490.1
AAFI02000041 Genomic DNA Translation: EAL66677.1
RefSeqiXP_640709.1, XM_635617.1

3D structure databases

SMRiQ54TV2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0215344

Proteomic databases

PaxDbiQ54TV2
PRIDEiQ54TV2

Genome annotation databases

EnsemblProtistsiEAL66677; EAL66677; DDB_G0281391
GeneIDi8623096
KEGGiddi:DDB_G0281391

Organism-specific databases

dictyBaseiDDB_G0281391 abcG5

Phylogenomic databases

eggNOGiKOG0065 Eukaryota
COG0842 LUCA
HOGENOMiCLU_000604_35_3_1
InParanoidiQ54TV2
OMAiEMNGIYM
PhylomeDBiQ54TV2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54TV2

Family and domain databases

CDDicd03232 ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR013581 PDR_assoc
PfamiView protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF08370 PDR_assoc, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCG5_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54TV2
Secondary accession number(s): Q8T688
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 22, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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