UniProtKB - Q54TF6 (LSM2_DICDI)
Probable U6 snRNA-associated Sm-like protein LSm2
lsm2
Functioni
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
By similarityGO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- mRNA splicing, via spliceosome Source: dictyBase
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
Reactomei | R-DDI-430039, mRNA decay by 5' to 3' exoribonuclease R-DDI-72163, mRNA Splicing - Major Pathway R-DDI-72165, mRNA Splicing - Minor Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Probable U6 snRNA-associated Sm-like protein LSm2 |
Gene namesi | Name:lsm2 ORF Names:DDB_G0281779 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0281779, lsm2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- catalytic step 2 spliceosome Source: GO_Central
- nucleolus Source: dictyBase
- precatalytic spliceosome Source: GO_Central
- U4/U6 x U5 tri-snRNP complex Source: dictyBase
- U6 snRNP Source: dictyBase
Other locations
- Lsm1-7-Pat1 complex Source: GO_Central
- P-body Source: GO_Central
Keywords - Cellular componenti
Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328006 | 1 – 117 | Probable U6 snRNA-associated Sm-like protein LSm2Add BLAST | 117 |
Proteomic databases
PaxDbi | Q54TF6 |
Interactioni
Subunit structurei
Component of the precatalytic spliceosome (spliceosome B complex).
Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.
By similarityProtein-protein interaction databases
STRINGi | 44689.DDB0233376 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 83 – 117 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 83 – 101 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 102 – 117 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3448, Eukaryota |
HOGENOMi | CLU_130474_3_0_1 |
InParanoidi | Q54TF6 |
OMAi | EERYPHM |
PhylomeDBi | Q54TF6 |
Family and domain databases
CDDi | cd01725, LSm2, 1 hit |
InterProi | View protein in InterPro IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR016654, U6_snRNA_Lsm2 |
PANTHERi | PTHR13829, PTHR13829, 1 hit |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
PIRSFi | PIRSF016394, U6_snRNA_Lsm2, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MLFFSFYKSL VGKEITVELK NDLSITGLLQ SVDQFLNIKL KDIKVNEEDK
60 70 80 90 100
YPYMISVKNC FIRGSVVRYV HLPAEDVDVE TLQDHSRLEA REQKKQNKQH
110
QEQTNQKSSN TTTTTTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000042 Genomic DNA Translation: EAL66651.1 |
RefSeqi | XP_640635.1, XM_635543.1 |
Genome annotation databases
EnsemblProtistsi | EAL66651; EAL66651; DDB_G0281779 |
GeneIDi | 8623246 |
KEGGi | ddi:DDB_G0281779 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000042 Genomic DNA Translation: EAL66651.1 |
RefSeqi | XP_640635.1, XM_635543.1 |
3D structure databases
AlphaFoldDBi | Q54TF6 |
SMRi | Q54TF6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0233376 |
Proteomic databases
PaxDbi | Q54TF6 |
Genome annotation databases
EnsemblProtistsi | EAL66651; EAL66651; DDB_G0281779 |
GeneIDi | 8623246 |
KEGGi | ddi:DDB_G0281779 |
Organism-specific databases
dictyBasei | DDB_G0281779, lsm2 |
Phylogenomic databases
eggNOGi | KOG3448, Eukaryota |
HOGENOMi | CLU_130474_3_0_1 |
InParanoidi | Q54TF6 |
OMAi | EERYPHM |
PhylomeDBi | Q54TF6 |
Enzyme and pathway databases
Reactomei | R-DDI-430039, mRNA decay by 5' to 3' exoribonuclease R-DDI-72163, mRNA Splicing - Major Pathway R-DDI-72165, mRNA Splicing - Minor Pathway |
Miscellaneous databases
PROi | PR:Q54TF6 |
Family and domain databases
CDDi | cd01725, LSm2, 1 hit |
InterProi | View protein in InterPro IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR016654, U6_snRNA_Lsm2 |
PANTHERi | PTHR13829, PTHR13829, 1 hit |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
PIRSFi | PIRSF016394, U6_snRNA_Lsm2, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LSM2_DICDI | |
Accessioni | Q54TF6Primary (citable) accession number: Q54TF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families