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Protein

Alcohol dehydrogenase class-3

Gene

adh5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.By similarity

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi176Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-DDI-2161541 Abacavir metabolism
R-DDI-5365859 RA biosynthesis pathway
R-DDI-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1By similarity)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284By similarity)
Gene namesi
Name:adh5
ORF Names:DDB_G0281865
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0281865 adh5

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003450231 – 379Alcohol dehydrogenase class-3Add BLAST379

Proteomic databases

PaxDbiQ54TC2

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0238276

Structurei

3D structure databases

ProteinModelPortaliQ54TC2
SMRiQ54TC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
InParanoidiQ54TC2
KOiK00121
OMAiATHKGWG
PhylomeDBiQ54TC2

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q54TC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTEGKVITC KAAVAWEAKK PLVIEDIEVQ PPQKGEVRIK ILYTGVCHTD
60 70 80 90 100
SYTLSGSDPE GIFPCILGHE GGGIVESIGE GVTSVKVGDH VIPLYIPECG
110 120 130 140 150
TCKFCTSNKT NLCSKIRITQ GKGQMPDGTT RFKCKGKEIF HFMGTSTFSQ
160 170 180 190 200
YTVLPEISCC VVREDAPLDK VCLLGCGITT GFGAAKITAK VEEGSTVAIF
210 220 230 240 250
GLGAVGLSVA QGAVDCGAKR IIGIDNNETK FGPGKDFGCT EFINPSKDLP
260 270 280 290 300
EGKTIQQHLV DITDGGVDYS FECIGNVNVM RAALECCHKG WGVSTIVGVA
310 320 330 340 350
PAGAEISTRP FQLVTGRVWK GSAFGGVKSR SQLPSIIDKY MDKKLKVDEY
360 370
VTFTYPLNEI NTAFDVMHEG KSLRSVVNL
Length:379
Mass (Da):40,553
Last modified:May 24, 2005 - v1
Checksum:i5E5B438509D3E3C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000043 Genomic DNA Translation: EAL66492.1
RefSeqiXP_640467.1, XM_635375.1

Genome annotation databases

EnsemblProtistsiEAL66492; EAL66492; DDB_G0281865
GeneIDi8623280
KEGGiddi:DDB_G0281865

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000043 Genomic DNA Translation: EAL66492.1
RefSeqiXP_640467.1, XM_635375.1

3D structure databases

ProteinModelPortaliQ54TC2
SMRiQ54TC2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0238276

Proteomic databases

PaxDbiQ54TC2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66492; EAL66492; DDB_G0281865
GeneIDi8623280
KEGGiddi:DDB_G0281865

Organism-specific databases

dictyBaseiDDB_G0281865 adh5

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
InParanoidiQ54TC2
KOiK00121
OMAiATHKGWG
PhylomeDBiQ54TC2

Enzyme and pathway databases

ReactomeiR-DDI-2161541 Abacavir metabolism
R-DDI-5365859 RA biosynthesis pathway
R-DDI-71384 Ethanol oxidation

Miscellaneous databases

PROiPR:Q54TC2

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADHX_DICDI
AccessioniPrimary (citable) accession number: Q54TC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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Main funding by: National Institutes of Health

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