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Protein

S-cell enriched with leucine-rich repeat-containing protein slrA

Gene

slrA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
S-cell enriched with leucine-rich repeat-containing protein slrA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:slrA
ORF Names:DDB_G0282069
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0282069 slrA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei1160 – 1180HelicalSequence analysisAdd BLAST21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003917691 – 1378S-cell enriched with leucine-rich repeat-containing protein slrAAdd BLAST1378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi634N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi704N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi710N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi740N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi771N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi788N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi801N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi826N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi843N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi861N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi875N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi907N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi953N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi970N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1090N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1360N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54T74

PRoteomics IDEntifications database

More...
PRIDEi
Q54T74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Only expressed in sentinel 'S-cells'.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0232377

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q54T74

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati143 – 165LRR 1Add BLAST23
Repeati167 – 188LRR 2Add BLAST22
Repeati191 – 212LRR 3Add BLAST22
Repeati213 – 235LRR 4Add BLAST23
Repeati236 – 257LRR 5Add BLAST22
Repeati260 – 281LRR 6Add BLAST22
Repeati282 – 304LRR 7Add BLAST23
Repeati307 – 329LRR 8Add BLAST23
Repeati331 – 353LRR 9Add BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili886 – 946Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi732 – 741Poly-Asn10
Compositional biasi747 – 751Poly-Asn5
Compositional biasi888 – 907Poly-AsnAdd BLAST20
Compositional biasi929 – 945Poly-AsnAdd BLAST17
Compositional biasi1229 – 1263Poly-AsnAdd BLAST35
Compositional biasi1270 – 1273Poly-Asn4
Compositional biasi1307 – 1318Poly-AspAdd BLAST12

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54T74

Identification of Orthologs from Complete Genome Data

More...
OMAi
CECYPNL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54T74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKNQIFSLK SLWSSSIFKI LYCYLFTSLL LILSTWVSVN DGLSVREHII
60 70 80 90 100
LLRLYFDTNG TTWYHNQGWK EYADCILAAD GSVRKALESI DPLTGQIPQY
110 120 130 140 150
LWADHFSQLD NNKTLYKIIH NQIQGHKVVI CNAFGITCED RINLTGIDLS
160 170 180 190 200
NNNLKGNITP YLPYLLHLRN LNLSNNHLSG CFPDGLLKAQ SLVALDLSYN
210 220 230 240 250
NISCTLSLAD SKAISYIDIS HNHLTGYFKN VWKTPNLLFL DLSFNKLYGT
260 270 280 290 300
ILKEFFRQKS LDYVNLSSNQ LIGFLPILSK SRISYLNISN NRLIGNITLL
310 320 330 340 350
TCWKAGSLRI FDAENNMFEG ALPESIFDHS PLQYVNLKGN IVKDPLPSIL
360 370 380 390 400
DCAKSEVKII VPDGLKQNKC DPKVSSNWVL ILNPLGEEFN IVGSDFGINS
410 420 430 440 450
KSINIQFQNG LHCVDNVTTI IKSNTIISCK NPQGRNSTYL KLTIPTGEPG
460 470 480 490 500
NFTVIKQQLY YYRPIIKSCS KVYKNIGGEI TILGSHLESF NKTSNGKKMI
510 520 530 540 550
TVSIGNIKNS FTNVTSSINS DGFSGEVISC RNADIITPDM ITCSIPSNTN
560 570 580 590 600
LQQPAEIQII IDGITAYVPI DSTRPHFLYK GVYNKDITIS KPTEYNQTIT
610 620 630 640 650
ISVPNETIID MDQVVRVLID DNDDSICKNI QHINKTSIQC LPYSETCGSN
660 670 680 690 700
VKVTLVTKYG EPQFTTSLNY PPPIITRVTQ GIDSTSNSII TINGKFLKTG
710 720 730 740 750
GKRNLSIKIN DTICCPLYNE YYYKQDELDD DNNNNNNNNN NSTTDINNNN
760 770 780 790 800
NIIKNNNLIK EEQILCYYQI NQSLPIHLNL PVTLTLSNQT VVKNNIYSQT
810 820 830 840 850
NSTCPNNCVK HRTNGCRSGI CECYPNLTGP SCDENIPEST ISNFSNYLPD
860 870 880 890 900
FILSFPKFIT NNTFNIKFLS ISEVNESGNI VDRFCSLNNN NNNNNNNNNK
910 920 930 940 950
NNNNNNNDSN NEKEVVEDEE EDLDYSSQND NNNINNNNNE NNNENKLNWK
960 970 980 990 1000
LINQTKTTNA LYTLKIKKKN VTLDILISSD NNQHREVYFA GEVIQVPKSS
1010 1020 1030 1040 1050
IELIVNLKGK WLFKDPKNQL KFNFLVKPVN DHDYSLCLPS PFVLISDEPF
1060 1070 1080 1090 1100
RWITMDVDSS TIFAKPSNRF LLNNYLVRVI EPNYKLSDSN LTLNLYYQFN
1110 1120 1130 1140 1150
QTTLKQQDNH GDDNSDNSIK YTEDSLKFRI DFSTFNSRRE INPKPRGCFK
1160 1170 1180 1190 1200
DNTHKFPYDY YIVFFGCASG LILVLVICIV QCSRIESRQR KQIIKSFKAT
1210 1220 1230 1240 1250
QKMPVEIKTP LLPPSFHFNF LDYNNMDLNN NNNNNNNNNN NNNNNNNNNN
1260 1270 1280 1290 1300
NNNNNNNNNN NFNDGSDTFN NNNKKNLNYE DNCDTVGFDG KENDIKNINN
1310 1320 1330 1340 1350
KKDEKEDDGD DDDDEDDDEY EDDTQPCSSG NSSRSKGSDG GSSSNSLSSD
1360 1370
KQSFNNGNEN NSIIPENKKK HLTIINKK
Length:1,378
Mass (Da):156,164
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB686F2C4DCF7EF33
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000044 Genomic DNA Translation: EAL66456.1

NCBI Reference Sequences

More...
RefSeqi
XP_640377.1, XM_635285.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL66456; EAL66456; DDB_G0282069

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8623330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0282069

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000044 Genomic DNA Translation: EAL66456.1
RefSeqiXP_640377.1, XM_635285.1

3D structure databases

ProteinModelPortaliQ54T74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232377

Proteomic databases

PaxDbiQ54T74
PRIDEiQ54T74

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66456; EAL66456; DDB_G0282069
GeneIDi8623330
KEGGiddi:DDB_G0282069

Organism-specific databases

dictyBaseiDDB_G0282069 slrA

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
InParanoidiQ54T74
OMAiCECYPNL

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54T74

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLRA_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54T74
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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