UniProtKB - Q54SS0 (ECH1_DICDI)
Protein
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
Gene
ech1
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.By similarity
Catalytic activityi
: fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 142 | Substrate; via amide nitrogenBy similarity | 1 | |
Sitei | 165 | Important for catalytic activityBy similarity | 1 | |
Sitei | 173 | Important for catalytic activityBy similarity | 1 |
GO - Molecular functioni
- delta3,5-delta2,4-dienoyl-CoA isomerase activity Source: dictyBase
GO - Biological processi
- fatty acid beta-oxidation Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Enzyme and pathway databases
Reactomei | R-DDI-9033241, Peroxisomal protein import |
UniPathwayi | UPA00659 |
Names & Taxonomyi
Protein namesi | Recommended name: Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrialCurated (EC:5.3.3.-By similarity) |
Gene namesi | Name:ech1 ORF Names:DDB_G0282261 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0282261, ech1 |
Subcellular locationi
- Mitochondrion By similarity
GO - Cellular componenti
- mitochondrion Source: UniProtKB-SubCell
- peroxisome Source: dictyBase
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000331593 | ? – 293 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial |
Proteomic databases
PaxDbi | Q54SS0 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 84 – 88 | Substrate bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the enoyl-CoA hydratase/isomerase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1681, Eukaryota |
HOGENOMi | CLU_009834_7_0_1 |
InParanoidi | Q54SS0 |
OMAi | HKACIGA |
PhylomeDBi | Q54SS0 |
Family and domain databases
Gene3Di | 1.10.12.10, 1 hit |
InterProi | View protein in InterPro IPR029045, ClpP/crotonase-like_dom_sf IPR018376, Enoyl-CoA_hyd/isom_CS IPR001753, Enoyl-CoA_hydra/iso IPR014748, Enoyl-CoA_hydra_C |
Pfami | View protein in Pfam PF00378, ECH_1, 1 hit |
SUPFAMi | SSF52096, SSF52096, 1 hit |
PROSITEi | View protein in PROSITE PS00166, ENOYL_COA_HYDRATASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q54SS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGSLFFTNA TPSTSILKIT DYKYLRLEKN DSTFVAELVL CRPKQYNSMD
60 70 80 90 100
DDFYNEFISI YDEIQNDSKI RCVILRGEGK GLTAGLNLGK IAPLITGDSE
110 120 130 140 150
VSQSQNNLDL FKMIRRWQAS LDKINKCSKP TIALIHGACI GGGVDMITAC
160 170 180 190 200
DIRLCSSDAK FSIRETKLSI IADLGTLQRI SKIVGSGFAR ELALTGKDID
210 220 230 240 250
AKTAERFNLV NHVYPDHDTL LSEGRKLALS IAQNSPLVVQ ATKLTLNHAD
260 270 280 290
DHTIDEGLYR VALQNAAFLK SDDLNESATS FFEKRQPIFK CNL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000046 Genomic DNA Translation: EAL66336.1 |
RefSeqi | XP_640315.1, XM_635223.1 |
Genome annotation databases
EnsemblProtistsi | EAL66336; EAL66336; DDB_G0282261 |
GeneIDi | 8623491 |
KEGGi | ddi:DDB_G0282261 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000046 Genomic DNA Translation: EAL66336.1 |
RefSeqi | XP_640315.1, XM_635223.1 |
3D structure databases
SMRi | Q54SS0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0267015 |
Proteomic databases
PaxDbi | Q54SS0 |
Genome annotation databases
EnsemblProtistsi | EAL66336; EAL66336; DDB_G0282261 |
GeneIDi | 8623491 |
KEGGi | ddi:DDB_G0282261 |
Organism-specific databases
dictyBasei | DDB_G0282261, ech1 |
Phylogenomic databases
eggNOGi | KOG1681, Eukaryota |
HOGENOMi | CLU_009834_7_0_1 |
InParanoidi | Q54SS0 |
OMAi | HKACIGA |
PhylomeDBi | Q54SS0 |
Enzyme and pathway databases
UniPathwayi | UPA00659 |
Reactomei | R-DDI-9033241, Peroxisomal protein import |
Miscellaneous databases
PROi | PR:Q54SS0 |
Family and domain databases
Gene3Di | 1.10.12.10, 1 hit |
InterProi | View protein in InterPro IPR029045, ClpP/crotonase-like_dom_sf IPR018376, Enoyl-CoA_hyd/isom_CS IPR001753, Enoyl-CoA_hydra/iso IPR014748, Enoyl-CoA_hydra_C |
Pfami | View protein in Pfam PF00378, ECH_1, 1 hit |
SUPFAMi | SSF52096, SSF52096, 1 hit |
PROSITEi | View protein in PROSITE PS00166, ENOYL_COA_HYDRATASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ECH1_DICDI | |
Accessioni | Q54SS0Primary (citable) accession number: Q54SS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families