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Entry version 94 (07 Oct 2020)
Sequence version 1 (24 May 2005)
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Protein

Protein phosphatase 2A scaffold subunit

Gene

pppA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffolding molecule which may coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:20493808). Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay (PubMed:20493808). The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway (PubMed:20493808).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-DDI-198753, ERK/MAPK targets
R-DDI-202670, ERKs are inactivated
R-DDI-389513, CTLA4 inhibitory signaling
R-DDI-5673000, RAF activation
R-DDI-5675221, Negative regulation of MAPK pathway
R-DDI-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DDI-69231, Cyclin D associated events in G1
R-DDI-69273, Cyclin A/B1/B2 associated events during G2/M transition

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 2A scaffold subunitCurated
Alternative name(s):
Protein phosphatase 2A 65 kDa regulatory subunitCurated
Protein phosphatase 2A A subunitCurated
Serine/threonine-protein phosphatase 2A regulatory subunit pppACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pppA
Synonyms:rcdB, veg124
ORF Names:DDB_G0283601
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0283601, pppA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003674751 – 584Protein phosphatase 2A scaffold subunitAdd BLAST584

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54QR9

PRoteomics IDEntifications database

More...
PRIDEi
Q54QR9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Sca1 complex composed of at least gefA, gefH, scaA, phr, and the protein phosphatase 2A subunits pppA and pho2B (PubMed:20493808).

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191258

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54QR9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 45HEAT 1Add BLAST39
Repeati46 – 84HEAT 2Add BLAST39
Repeati86 – 123HEAT 3Add BLAST38
Repeati168 – 206HEAT 4Add BLAST39
Repeati207 – 239HEAT 5Add BLAST33
Repeati240 – 278HEAT 6Add BLAST39
Repeati279 – 317HEAT 7Add BLAST39
Repeati318 – 356HEAT 8Add BLAST39
Repeati358 – 395HEAT 9Add BLAST38
Repeati397 – 434HEAT 10Add BLAST38
Repeati441 – 479HEAT 11Add BLAST39
Repeati480 – 512HEAT 12Add BLAST33
Repeati513 – 551HEAT 13Add BLAST39
Repeati553 – 584HEAT 14Add BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0211, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015533_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54QR9

KEGG Orthology (KO)

More...
KOi
K03456

Identification of Orthologs from Complete Genome Data

More...
OMAi
WASEAII

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54QR9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR021133, HEAT_type_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02985, HEAT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077, HEAT_REPEAT, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54QR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASINTESDD YHPIVILIDE LKNEDIQLRL NSIKKLQSIA KALGPERTRT
60 70 80 90 100
ELIPYLQDSV LEDEDEVLVV LSEELGNLIE FVGGAEHAVC LLPPLQILAG
110 120 130 140 150
AEELVVREKA VESLCKIAKE IPTSSFEESF LPLLFSLSKA DWFTSRTSAC
160 170 180 190 200
GLFTVSYPRA NAEMKKSLRK TFGGLCHDDT PMVKRAAATN LGSFAKQIEK
210 220 230 240 250
ESVKSEILPL FQSLSTDEQD SVRLLGVENC ALLGSMLTNE ENIQFILPTI
260 270 280 290 300
KASSLDKSWR VRYMVARLLK ELCESMGTEI TKTELIGAFV KLLKDTEAEV
310 320 330 340 350
RTEASLRIAD VCSLLTKEMN IKTILPCVKD LVSDSSQHVR AALAQVIMSL
360 370 380 390 400
APIYGKEDTL THLLELFLHL LKDDFPDVRL NIISKLDQVS KVIGIEMLSQ
410 420 430 440 450
SLLPAIVELA EDHQWRVRLA IIDYIPLLAS QLGVEFFDEK LGNLCMTWLG
460 470 480 490 500
DPVFSIREAA TNNLKKLTEV FGVDWAKNNI IPKVLSLHSH PNYLYRMTTL
510 520 530 540 550
FSISTLSTVV GGDVISSSMV PLLAKMVSDK VPNIRFNVAK TFQTIIPLLD
560 570 580
STIVQSRVKP LLVKLHEDTD KDVKFYASQA LQLC
Length:584
Mass (Da):65,076
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74A4AB12F62A359F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti494L → F in AAB03670 (Ref. 1) Curated1
Sequence conflicti516S → F in AAB03670 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U61987 mRNA Translation: AAB03670.1
AAFI02000056 Genomic DNA Translation: EAL65567.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL65567; EAL65567; DDB_G0283601

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0283601

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61987 mRNA Translation: AAB03670.1
AAFI02000056 Genomic DNA Translation: EAL65567.1

3D structure databases

SMRiQ54QR9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191258

Proteomic databases

PaxDbiQ54QR9
PRIDEiQ54QR9

Genome annotation databases

EnsemblProtistsiEAL65567; EAL65567; DDB_G0283601
KEGGiddi:DDB_G0283601

Organism-specific databases

dictyBaseiDDB_G0283601, pppA

Phylogenomic databases

eggNOGiKOG0211, Eukaryota
HOGENOMiCLU_015533_2_1_1
InParanoidiQ54QR9
KOiK03456
OMAiWASEAII
PhylomeDBiQ54QR9

Enzyme and pathway databases

ReactomeiR-DDI-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-DDI-198753, ERK/MAPK targets
R-DDI-202670, ERKs are inactivated
R-DDI-389513, CTLA4 inhibitory signaling
R-DDI-5673000, RAF activation
R-DDI-5675221, Negative regulation of MAPK pathway
R-DDI-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DDI-69231, Cyclin D associated events in G1
R-DDI-69273, Cyclin A/B1/B2 associated events during G2/M transition

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54QR9

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR021133, HEAT_type_2
PfamiView protein in Pfam
PF02985, HEAT, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077, HEAT_REPEAT, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei2AAA_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54QR9
Secondary accession number(s): Q23922
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 24, 2005
Last modified: October 7, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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