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Entry version 91 (07 Oct 2020)
Sequence version 2 (14 Apr 2009)
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Protein

Probable E3 ubiquitin-protein ligase DDB_G0283893

Gene

DDB_G0283893

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable E3 ubiquitin-protein ligase.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2042 – 2113UBR-typePROSITE-ProRule annotationAdd BLAST72
Zinc fingeri3225 – 3270ZZ-typePROSITE-ProRule annotationAdd BLAST46

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-6798695, Neutrophil degranulation
R-DDI-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase DDB_G0283893 (EC:2.3.2.-)
Alternative name(s):
Probable E3 ubiquitin-protein transferase DDB_G0283893Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DDB_G0283893
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0283893

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003692471 – 5875Probable E3 ubiquitin-protein ligase DDB_G0283893Add BLAST5875

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54QG5

PRoteomics IDEntifications database

More...
PRIDEi
Q54QG5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0267140

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3313 – 3332UIMCuratedAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1300 – 1328Sequence analysisAdd BLAST29
Coiled coili4118 – 4146Sequence analysisAdd BLAST29
Coiled coili4585 – 4618Sequence analysisAdd BLAST34
Coiled coili5819 – 5846Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 52Poly-AsnAdd BLAST35
Compositional biasi162 – 175Poly-AsnAdd BLAST14
Compositional biasi271 – 277Poly-Thr7
Compositional biasi310 – 316Poly-Pro7
Compositional biasi548 – 555Poly-Asn8
Compositional biasi641 – 656Poly-ThrAdd BLAST16
Compositional biasi675 – 681Poly-Asn7
Compositional biasi733 – 738Poly-Thr6
Compositional biasi928 – 931Poly-Leu4
Compositional biasi1082 – 1094Poly-ThrAdd BLAST13
Compositional biasi1340 – 1343Poly-Ser4
Compositional biasi1347 – 1351Poly-Thr5
Compositional biasi1352 – 1355Poly-Ala4
Compositional biasi1736 – 1743Poly-Asn8
Compositional biasi1787 – 1793Poly-Ala7
Compositional biasi1811 – 1814Poly-Lys4
Compositional biasi1970 – 1976Poly-His7
Compositional biasi2121 – 2133Poly-GlnAdd BLAST13
Compositional biasi2146 – 2152Poly-Gln7
Compositional biasi2176 – 2187Poly-SerAdd BLAST12
Compositional biasi2189 – 2197Poly-Asn9
Compositional biasi2737 – 2742Poly-Thr6
Compositional biasi3092 – 3102Poly-SerAdd BLAST11
Compositional biasi3200 – 3203Poly-Ser4
Compositional biasi3295 – 3309Gln-richAdd BLAST15
Compositional biasi3341 – 3351Poly-ThrAdd BLAST11
Compositional biasi3468 – 3471Poly-Thr4
Compositional biasi3472 – 3476Poly-Ala5
Compositional biasi3477 – 3488Poly-ThrAdd BLAST12
Compositional biasi3766 – 3774Poly-Asn9
Compositional biasi4206 – 4213Poly-Ser8
Compositional biasi4223 – 4235Poly-GlyAdd BLAST13
Compositional biasi4308 – 4317Poly-Gln10
Compositional biasi4619 – 4628Poly-Ser10
Compositional biasi4638 – 4643Poly-Gly6
Compositional biasi4741 – 4746Poly-Gln6
Compositional biasi5533 – 5538Poly-Gly6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UBR4 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2042 – 2113UBR-typePROSITE-ProRule annotationAdd BLAST72
Zinc fingeri3225 – 3270ZZ-typePROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1776, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_223060_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54QG5

KEGG Orthology (KO)

More...
KOi
K10691

Identification of Orthologs from Complete Genome Data

More...
OMAi
DEPHEYL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54QG5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025704, E3_Ub_ligase_UBR4
IPR036322, WD40_repeat_dom_sf
IPR003126, Znf_UBR
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13764, E3_UbLigase_R4, 1 hit
PF00569, ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00396, ZnF_UBR1, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51157, ZF_UBR, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54QG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPDLLLAIA LSESLMDNNN NNNNNNNNNN NNNNNNNNNN NNNNSNNNNN
60 70 80 90 100
KNVEMGEAEK QPPEDKISTY FKELTGLLKK DTIVKNLKPL LALLKSKELL
110 120 130 140 150
LDQIYFLSKI LESISFNIVF NGKEKDKVEN EFEIFCKDTI EFCLNILEKW
160 170 180 190 200
GNGDIDLSTI PNINNNNNND NNSNNKTDDN NQSNNSKKLT PLTLLSVIDM
210 220 230 240 250
LCCIEFPSTE IDKTFDNIPS FLNVSELDEI LDSNNQDNKE NKKEDKESSK
260 270 280 290 300
PIASSPIPIT TTNIEKPTIA TTTTTSTSNS NIFSQFLNEG LKVEGLNETM
310 320 330 340 350
IPSFKPSTLP PPPPTPTSTI TTQPLPSSTI TQPESYSNCG NGEGGMETFA
360 370 380 390 400
KVNSNYFNNK LFGSSRLLSI CSKLLVPYHA DLTSPSTVEK FETFKKNQTL
410 420 430 440 450
IQDFMSNVQD IIFSEGFDSL DKQTAPWTID FLGNLIGTLR SFQSFSISNN
460 470 480 490 500
LSYYNNDSKF LSKHLFENIF EVLGSKLDYP GLQIKAEIFF SLCILSDVNK
510 520 530 540 550
MKIDIVKLLE RDQSTPLDKE YLVLNPQLII LAIDLVFKNI REITEIQNNN
560 570 580 590 600
NNNNNVDFNE LLKIDSTVDQ STITGVEKPT TKFLLSEPLD GTGVEGWFDF
610 620 630 640 650
SNENKQLFSK DSLFKLFIKP QLLDTLFNIL YLCYFKPTKS TTTTTTATTT
660 670 680 690 700
TTTTTTNESI PMETTRSSTP IPIVNNNNNN NDSKSNSKKS PPIKINDSYF
710 720 730 740 750
GEDDLFGGLF DQSSTSIRSS SNKVNEGTPK SSTTTTTTNA TIISTPANSN
760 770 780 790 800
IKESSNDDGD HDEDIMKCKI FNLLSFIYLL QDDPMYKEFT KNHLTLTHLR
810 820 830 840 850
ILFTLIAPSS NPSIMAPKSK NSTVFKLLTN ICFLLCKNSI ISDTLLDQFI
860 870 880 890 900
GFVFTSVDSQ LLTLPKEQLA WIAWIFVKKQ STMVVGATNS VMVVSLWDGF
910 920 930 940 950
LKNSSRVIRE VSLVSSPFKE VISLDYILLL LFSFHTLDEK HRLGIVSTLC
960 970 980 990 1000
QSFNEIVCKV KSDQSFLPNS LMLSRCLMVF NYILFNFETV NPILSKLFNS
1010 1020 1030 1040 1050
QLLSFKKSNY QVGEFYKLSI VNLNYSGTIE KLIKKSAFIN NDGLIGLPEF
1060 1070 1080 1090 1100
YDLYFIPPPN NTLTSPSKSI NSSSNNILSP ITPTNTTTTT TTTTPSTTSI
1110 1120 1130 1140 1150
PTNNEDWFNH SNNLEKITSL LQKSTNNDNC YEQFYNNIVS LCSLTPTVKS
1160 1170 1180 1190 1200
TQDGSSLDSL YFDYIVASSL KFLSCLPLSL SFLKAIKDPQ TFTTVSNTSP
1210 1220 1230 1240 1250
IFITYLKSIY PSQCNNPEIP WLAHTENILT HFKYNGGTPS DSSLRVNGIV
1260 1270 1280 1290 1300
QSSLAYLTKV FDVGTSLNIN KKLAESSGNV DTSGGGDSYF DGWESLFNDD
1310 1320 1330 1340 1350
DDEEEDEEEE EEMDEDDSEN DEDEDSEESE KEQNKDNLKS SSSTVPTTTT
1360 1370 1380 1390 1400
TAAAATTTAT ATTKESTIRS NISTLLPSLI NFIIDTLGHY RGIYKKSLIE
1410 1420 1430 1440 1450
QLSNHSNALH VKLIQELYIL SSKTEVLEVM KSLDFSTDDR NTVEKWDEEY
1460 1470 1480 1490 1500
KPDPLVPKDQ KQLFGWSVQP YNPSFTEGKV YSVALQSIIR LLLTLSNQAL
1510 1520 1530 1540 1550
VHWDNVTETN PDSTKPILSK VSELIFEQVY ISTDRSFSFL KDHYDNYSSL
1560 1570 1580 1590 1600
ISGAQSGYLI NQIKLANFES ISKILIDPTF SPSNNSSNKF LSENSYLLTV
1610 1620 1630 1640 1650
LIGYVDSLIS MSKLNGSHIY CYYISGFNGS VARGTRDFEF VLPTGNLQLL
1660 1670 1680 1690 1700
ISVLFNNPCE KFNLKVLSAL VHFMSISTPS EFFTSFRSHC ITTFSKIPIN
1710 1720 1730 1740 1750
DLKLWFEQKL LGINNFEKNS TATNGTEKMD IEIILNNNNN NNNKVEEKSG
1760 1770 1780 1790 1800
KINSTVSIQE QIIRLIGLLI GNKDLSCYSK DYLQQQAAAA LAAKESEELL
1810 1820 1830 1840 1850
QQQLLQESEG KKKKRSSGSS TPTKIPGKKT PITSGQDSNS SPALTASSSP
1860 1870 1880 1890 1900
PSLEFVDWDE KVTSFALTLF DVLLSSLNNA FTVWIDQPKL LKGYFELLQF
1910 1920 1930 1940 1950
IAMGQHQLLK LFNEISNLSS PLLTNPTIDQ LESLNLLVEF IENILDLSKS
1960 1970 1980 1990 2000
LKKPSSDQQH HSGGCHHSNH HHHHHHSRKD EVMVDKSSIT NVVDEDILKD
2010 2020 2030 2040 2050
DVEVMDEEDE DELQYLSEDE KVVNGNENTG EEDDEERKLS SKVCTYTFTK
2060 2070 2080 2090 2100
NDYIDQHWYF CYTCGLKFSE GCCSVCVKVC HKGHQVSYSR YSRFFCDCGA
2110 2120 2130 2140 2150
GAGKGNPCKA LKPRLYSPPK QLQQQQQQQQ PQQPPQDQQK NVAAEQQPQQ
2160 2170 2180 2190 2200
QQEEQQVAST TSSATNTNDQ PIIPDSLSSS SSNSSPSFNN NNNNNNNGTT
2210 2220 2230 2240 2250
GSGNTFSSIN NYFFNLPTQQ DKEQLFNEIF NDKSNIISKL SELYPKLIEM
2260 2270 2280 2290 2300
YKKVQTDLIK PQSDSNSNKL EVFEESSTQS ISSREIISKT DIFTTKKVSK
2310 2320 2330 2340 2350
NGTFEAKLKL EGVEGNQLKT FLSSGPIQRK AIASTSKGLL AIAEGDSVSL
2360 2370 2380 2390 2400
FNSSKILDDD AQLDKHSFSK ALSKSSVAYP IVSMVFNPLN ERFLAVVGFK
2410 2420 2430 2440 2450
EVKILTINQK DEIVDQLVID LSLDALGETI YIIKVEWIIG SQVELAIVTN
2460 2470 2480 2490 2500
EFIKIYDLSK DNLSPIHFFS LLEDSIKDMC LVQKNGKNHI LALSNYGLLY
2510 2520 2530 2540 2550
FQAIEDSIDN ESCIMIETLQ VPINKISAGV SVHYNIDLDL VIASYTNGEC
2560 2570 2580 2590 2600
YAFQVNDTMT NVTRSFPIMD PAKKLPMPAQ YFINLSPMFP NVYACLAARG
2610 2620 2630 2640 2650
GYLLGFKMGT KDISIQNLKL TQRVEGMTIL NRSSPKLLIL FDDGSIGRYD
2660 2670 2680 2690 2700
FNLENTIQQP LPTTSTTTDS INESDKKGLD ILLYLKSKYQ DSINKNNSGS
2710 2720 2730 2740 2750
SINSSGNNVA TVSSSTTSTS AVIKSPPPLS SLLLQPTTTT TTSPVFPIDF
2760 2770 2780 2790 2800
FESTECITPN VKYGGDPLQW FSQDVIKQKL ASNDEYIVCQ SLETLTLVIM
2810 2820 2830 2840 2850
NNNFNNAICG IRILVGNAST KHIPTEIRVF NRTIQLKEGQ RRWYDIPFTT
2860 2870 2880 2890 2900
EETLRSIKKV SFTAGSTFTM GTSPIIDQVE VYAKNKDSLG FNDSDDSDDE
2910 2920 2930 2940 2950
FPTVDENVTS SGLSTSAGGS GGGVAGTNDS TADKHTPLEI VILHCFNSLK
2960 2970 2980 2990 3000
NYFSNHVAND DSQKFIELKE KTLSILPSMI TDSQLSFVRS SIKKLLKILS
3010 3020 3030 3040 3050
TNSEHYQTLK HSIQLKYASQ TVSSILSNSG GTIPNSADLE KLDYLVAALK
3060 3070 3080 3090 3100
KISSSNPNNL EKYLFKDHPN FLSDLLTIYR NTTSPSSSKG KSSSASASSS
3110 3120 3130 3140 3150
SSTTTATSTL PSNTQSGSNN GAVSSNALLY SDSFISNLVQ LLWNCQRSKI
3160 3170 3180 3190 3200
FSTDLIFTLL KSLLSHSNEI IRTRSSLILV SFISKSGNNS TVANLLPPPS
3210 3220 3230 3240 3250
SSSNENVVDN DNTNKENEGD IQMVDEVLFS CDLCNINPIT GKRWNCSNCG
3260 3270 3280 3290 3300
DFDLCNQCYQ NPEKDHPKDH IFKEFIIDEP MKDGDEKEST NEPPQQQKQQ
3310 3320 3330 3340 3350
DQQLQQDLQD DSEYDEELKI AISMSLNNNN NNNNNNESMD TSTLTTTTTT
3360 3370 3380 3390 3400
TNKTTPTTNE EPMVGFIKLI IEEIIVSYEK GFSFMIPYMQ ILYSTILHNT
3410 3420 3430 3440 3450
TFILNNNQLS NQLVTTLVNL ISKHKSNLSK FLSTKSNNLE GDILIFSLLS
3460 3470 3480 3490 3500
LLLDSDEQKR QKIQSKQTTT TAAAAATTTT TATATVTTPS VVTTPHSLPS
3510 3520 3530 3540 3550
TLIYHLSKLF IDRDIIQLLR LWIEQLYTCI SESHGLSVGE ERDSPFGALL
3560 3570 3580 3590 3600
VPSIDENQTL PKNRFTPFFG KYLPQSMGSI HLLLSKAIFK LMITFYRCER
3610 3620 3630 3640 3650
RKKSITQTTP TLIKPSEWTN LICSFIHSKK TVSIVKYPKK LLFLIYQTKS
3660 3670 3680 3690 3700
SYYSIRDEFL LKKKFAGILD LEGKTKGFSD EIGYDHLAKL ISYLTLMLEV
3710 3720 3730 3740 3750
ASDRPKSWQF FCAHNDVLPK LYKILFNLAE EPSSLLLELL TYVFVDEIAE
3760 3770 3780 3790 3800
QPLSSTSQDT QQESSNNNNN NNSNDILMQD VDTKAKHISI FLQEQYFNVL
3810 3820 3830 3840 3850
IFNILLESNS SDLRSIASSF IYYLWRSSNN EQRIFINKSL WSKLNNVASY
3860 3870 3880 3890 3900
GKNASEFMDL LTYFLNETDS QSWKDQHNEF SNKLIESFKQ QNQISLNHPN
3910 3920 3930 3940 3950
SQIYNSLGKI LEFDGYYLES EPCLVCNNPE VQYQTSRLES LKQEVKFSEY
3960 3970 3980 3990 4000
SQLIKFNGVY NISKIMIQLH DVKKGKMIKT INLFYNNKPV ADIGDLKGKF
4010 4020 4030 4040 4050
NQWKKLKQVH FTPSQTEKAV VFQIPISARN FMIEYFDFHD NLQAASSEKL
4060 4070 4080 4090 4100
QCPRCSRIVT DKHGICKNCH ENAYQCKHCR NINYENLDAF LCNECGFCKH
4110 4120 4130 4140 4150
AKFDYSFVCK PTIAIEKIEN QEDHKRAIQT IEKESENAHK KYQRLIGFKK
4160 4170 4180 4190 4200
VISGLINSFE TQEPWSKDDL IKSSGGTISI ANTSTNSTGS NNQSINSSSG
4210 4220 4230 4240 4250
NISTNSSSSS SSSFGISNQS SSGNGGGGVG SGGGGVINQS GTSNNSSFLT
4260 4270 4280 4290 4300
LRINKKIGYL SRLYERECRN IYEGLSKSVQ ILQTNRMEIS KYMNFISGGG
4310 4320 4330 4340 4350
QPSSNDKQQQ QQQQQQQSSR QCPVSIHLRE ENKCYGCSNS YIEQVLCLLN
4360 4370 4380 4390 4400
SFCRNSELTP IKNLLIEKGL PKEIFFNNIH HGKSIAKGWA KSSLSYLTKS
4410 4420 4430 4440 4450
NIDCTSMVNQ WIKDKIYYTL CYYSSLDVPN MVSSEISLLK ECSSLSDNIW
4460 4470 4480 4490 4500
PQRLSFIMEL FFKALSSGSQ SPVVSEYIIL PCLKIIIYLC TLDRKGAFIT
4510 4520 4530 4540 4550
KDAKDLEISQ KLLATRFEKL KSSKKQAIAL AATATATATA ANASLTSTIE
4560 4570 4580 4590 4600
KKIEALSSLL SPNTVNNIAL SVASSLLSPQ QMQLQIQQQI ALQQQQIQQQ
4610 4620 4630 4640 4650
IQQQQQQLNE SVSGLKILSP SSSSSSPSGV GATGSENGGG GSGSSSGSSV
4660 4670 4680 4690 4700
SGSGSISSSQ DPNILSIFDN DTSNAGANES WDGDDNPIAN AWSSKYENYL
4710 4720 4730 4740 4750
SNFNVNSSIG EISKSLKPLS QDELKSKYFK RWYAQVKKRK QQQQQQSSGI
4760 4770 4780 4790 4800
GYATQSSFEV LFEEKWLEKL LFNSTSSIRL EIITLMGILS KNSNSRSLKF
4810 4820 4830 4840 4850
LDLLTKILPN ATEAGEYSAE FFGLFNSFIS TSQDRKIYLA VKGFIPFICD
4860 4870 4880 4890 4900
AIIKEIEHIK SKEGSFSTDV SQGFVLKTLV AILKSFLDVP TLKAKMKKDN
4910 4920 4930 4940 4950
MLEKVLDAFL SLRGVIVQKN KLTEDSVRYL QELMKSLNNE SVQDNKKFMA
4960 4970 4980 4990 5000
ANIKALAKYQ SDGRTPIFIF EQLCNIVCPT KPDPIYQLIL FKAASQEEYI
5010 5020 5030 5040 5050
RGSMNRNPYT SNTFGGPLMR DVKNKICKAL DLGSFLDDDN GMELLVDNKI
5060 5070 5080 5090 5100
IKLDLPIKKV YELVWKKSPQ ALRTADINIP MNVVYRLQGL DGEATEEIIE
5110 5120 5130 5140 5150
TLNDNNSEEK DPEVEYEITS VMAECGGLES MISMIERIND FSIEKELAQL
5160 5170 5180 5190 5200
VIKLLYHCCK IKINRQKLLT LNTVGRLLEK LKQAFHQPEL SEHLLVIIES
5210 5220 5230 5240 5250
VVSEANRDYL RGSNSSTSLS HHKDINEAQE QMNMFLDKLN GAQVMSNPKI
5260 5270 5280 5290 5300
IQAITRIIPF LTYGHTEIMD YLVDFFTPYL NFQEFDDSKS KDTNHVYHLD
5310 5320 5330 5340 5350
FFTKLMENTR PDSNGRSIRS IIIKRGITKS LVDYLLNYFP ENGDKTSQEW
5360 5370 5380 5390 5400
LSSLEKPALP FVLVLLKGLA MGHEPTQNMT LESNLIKRIH ILEETAGTSA
5410 5420 5430 5440 5450
KIGSLAENLL ESIAEGNEKT SKIVSDTRKE SKMEKLSHAQ KHREDVLKQL
5460 5470 5480 5490 5500
GLAQQGKHIM ANVVPGSIED LDDDEGFTCM VCREGYSFKP TDVLGIYTFS
5510 5520 5530 5540 5550
KRIPLTSVGE TTCPPSSTTN VAASLSLSPS SSGGGGGGAL YYGFTTVTHF
5560 5570 5580 5590 5600
NFIHFNCHRD ATKADRSMKV PKEEWEGAAL RNQQTKCNGL FPVLPPKMNS
5610 5620 5630 5640 5650
DAFTPYSDKF WVNLNNISRV EGPKFRILSH DLKFLLIRLA KDESFSTDSK
5660 5670 5680 5690 5700
GGGKESNIRI APMFVQLGMF LLDQKLVGGN SANQLRRPQF EKTLAQFTTL
5710 5720 5730 5740 5750
PLETAITSMY QMLSDNVPYF LVVSIFLHSP KEFENQKFNY LTKLLAYAFV
5760 5770 5780 5790 5800
DYLTTNTKNG LSSPDEPSKD KLFDITRPWL IFFSLLSKFH SIIKPSSCTE
5810 5820 5830 5840 5850
ENWIQETKNH LSTNCTKIQV DVKELLNCFE NELKEFQDEM EFFDDEGLLK
5860 5870
NVLLNNKDSN EYLLKLYKSV KSNKK
Length:5,875
Mass (Da):658,224
Last modified:April 14, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55704D9E63C6CA36
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000057 Genomic DNA Translation: EAL65561.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL65561; EAL65561; DDB_G0283893

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0283893

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000057 Genomic DNA Translation: EAL65561.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0267140

Proteomic databases

PaxDbiQ54QG5
PRIDEiQ54QG5

Genome annotation databases

EnsemblProtistsiEAL65561; EAL65561; DDB_G0283893
KEGGiddi:DDB_G0283893

Organism-specific databases

dictyBaseiDDB_G0283893

Phylogenomic databases

eggNOGiKOG1776, Eukaryota
HOGENOMiCLU_223060_0_0_1
InParanoidiQ54QG5
KOiK10691
OMAiDEPHEYL
PhylomeDBiQ54QG5

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-DDI-6798695, Neutrophil degranulation
R-DDI-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54QG5

Family and domain databases

Gene3Di3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR025704, E3_Ub_ligase_UBR4
IPR036322, WD40_repeat_dom_sf
IPR003126, Znf_UBR
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF13764, E3_UbLigase_R4, 1 hit
PF00569, ZZ, 1 hit
SMARTiView protein in SMART
SM00396, ZnF_UBR1, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51157, ZF_UBR, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiY3893_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54QG5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: October 7, 2020
This is version 91 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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