Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 96 (02 Jun 2021)
Sequence version 1 (24 May 2005)
Previous versions | rss
Add a publicationFeedback
Protein

SWIM-type domain-containing protein

Gene

DDB0185879

Organism
Dictyostelium discoideum (Slime mold)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonucleaseARBA annotation, Hydrolase, Nuclease
Biological processDNA damage, DNA recombinationARBA annotation, DNA repairARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SWIM-type domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DDB0185879Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0284175

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54Q14

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0305296

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54Q14

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini253 – 292SWIM-typeInterPro annotationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni73 – 101DisorderedSequence analysisAdd BLAST29
Regioni301 – 358DisorderedSequence analysisAdd BLAST58
Regioni453 – 563DisorderedSequence analysisAdd BLAST111
Regioni667 – 690DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi73 – 98Polar residuesSequence analysisAdd BLAST26
Compositional biasi314 – 333Pro residuesSequence analysisAdd BLAST20
Compositional biasi334 – 358Polar residuesSequence analysisAdd BLAST25
Compositional biasi453 – 468Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi488 – 547Polar residuesSequence analysisAdd BLAST60
Compositional biasi548 – 563Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPF family.ARBA annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2379, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_316744_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54Q14

Identification of Orthologs from Complete Genome Data

More...
OMAi
PIGDFIF

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
1.10.150.110, 1 hit
1.10.150.50, 1 hit
1.10.150.670, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR042530, EME1/EME2_C
IPR006166, ERCC4_domain
IPR011335, Restrct_endonuc-II-like
IPR013761, SAM/pointed_sf
IPR036388, WH-like_DNA-bd_sf
IPR007527, Znf_SWIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02732, ERCC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00891, ERCC4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit
SSF47802, SSF47802, 1 hit
SSF52980, SSF52980, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50966, ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54Q14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNPNQFIID ALELIIKNRS SYHFQRNLKV AIDSIKLYPM PLKTKDDIKL
60 70 80 90 100
LRGCGPTIVD IIFQIIQSNK NNNNNNNNNN NNNNNNNITN NNNSDGGIPK
110 120 130 140 150
ELENYIAPES VKEFLISIDQ SFVQYLPKLE EAGYNKLNFL KNLNEKAMDK
160 170 180 190 200
LSIPLGHQTP ILENAKILKL YYDYTKLNNN SNNIINNYSL DGNMITLIGK
210 220 230 240 250
PYIDIDDLKK KCSEDVFLKA LSSLFNHKIK TIHVEHNEIT AITESHSIPN
260 270 280 290 300
TTYKIRFEIS PDGTIVRDHC ECRYLNSTRW CKHKVSVFLI FNENTGERGK
310 320 330 340 350
RLYCQSTSPT SPTSPTSPTS PTSPTPPKPS RPVTKLSPIT SLTSKKSPNN
360 370 380 390 400
NNNKKEYTPA HRSGAWAILL ALYDNEISNG NDNDRGKRYL LKEEILSNGN
410 420 430 440 450
KYLSSGRMDT GGHWLSNKTL IDHNLISKSG SPLQFILTKT GYELARKLKS
460 470 480 490 500
FEDSSTDNKN KDDCDNNNID NDNGSNSSKD EGSDESCDND NQITITTIDK
510 520 530 540 550
RNPNWKTQLK NKTNNINNNN NNNNTNIVKN NNNNNNNNNN NNNSNNKNNK
560 570 580 590 600
RRDSDNNDNF SNGSEERLFL ERELFNENWS DSDEELTQFM VDNTVFPNSK
610 620 630 640 650
VKELLYNERE VIIDNVLLIV DNREVMDKDQ SDLLDKLRSS NIQLEIRKLP
660 670 680 690 700
IGDFIFIAKC RYNNNNNNNN NNDNDNDDNG NNNNNNNNND IVINREPFEL
710 720 730 740 750
MYDIIIERKK LADLVSSRKD GRYREQKQRI KTLKKFGLTN AIYLIEGDNS
760 770 780 790 800
NGAIHTDIYE DSIMETLIED EFIVQLTDGL DLTKEYLLNL YDHFKKSKYR
810 820 830 840 850
SLSTLRFADY EQIQQVSCSM KLKDLFALQL LQIDGVTPPK AKAIINKYPT
860 870 880 890 900
PRHLVEAYNN LINEIETSDE ETLNQSKNSQ DKLLENLTYS QRFNGKKLKI
910 920
GHDISKLISI LYNDENQYQF D
Length:921
Mass (Da):105,732
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF995451D854C6BEC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI01000104 Genomic DNA Translation: EAL65355.1

NCBI Reference Sequences

More...
RefSeqi
XP_638710.1, XM_633618.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8624454

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0284175

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI01000104 Genomic DNA Translation: EAL65355.1
RefSeqiXP_638710.1, XM_633618.1

3D structure databases

SMRiQ54Q14
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0305296

Proteomic databases

PaxDbiQ54Q14

Genome annotation databases

GeneIDi8624454
KEGGiddi:DDB_G0284175

Organism-specific databases

dictyBaseiDDB_G0284175

Phylogenomic databases

eggNOGiKOG2379, Eukaryota
HOGENOMiCLU_316744_0_0_1
InParanoidiQ54Q14
OMAiPIGDFIF

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54Q14

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.150.110, 1 hit
1.10.150.50, 1 hit
1.10.150.670, 1 hit
InterProiView protein in InterPro
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR042530, EME1/EME2_C
IPR006166, ERCC4_domain
IPR011335, Restrct_endonuc-II-like
IPR013761, SAM/pointed_sf
IPR036388, WH-like_DNA-bd_sf
IPR007527, Znf_SWIM
PfamiView protein in Pfam
PF02732, ERCC4, 1 hit
SMARTiView protein in SMART
SM00891, ERCC4, 2 hits
SUPFAMiSSF47769, SSF47769, 1 hit
SSF47802, SSF47802, 1 hit
SSF52980, SSF52980, 1 hit
PROSITEiView protein in PROSITE
PS50966, ZF_SWIM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ54Q14_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54Q14
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 2, 2021
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again