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UniProtKB - Q54PY7 (M2OM_DICDI)
Protein
Probable mitochondrial 2-oxoglutarate/malate carrier protein
Gene
ucpC
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity).
By similarityGO - Molecular functioni
- antiporter activity Source: GO_Central
- dicarboxylic acid transmembrane transporter activity Source: dictyBase
- malate transmembrane transporter activity Source: GO_Central
- oxaloacetate transmembrane transporter activity Source: GO_Central
- succinate transmembrane transporter activity Source: GO_Central
- sulfate transmembrane transporter activity Source: GO_Central
- thiosulfate transmembrane transporter activity Source: GO_Central
GO - Biological processi
- dicarboxylic acid transport Source: dictyBase
- malate transmembrane transport Source: GO_Central
- oxaloacetate transport Source: GO_Central
- phosphate ion transmembrane transport Source: GO_Central
- succinate transmembrane transport Source: GO_Central
- sulfate transport Source: GO_Central
- thiosulfate transport Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-DDI-1614517, Sulfide oxidation to sulfate R-DDI-428643, Organic anion transporters R-DDI-70263, Gluconeogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Probable mitochondrial 2-oxoglutarate/malate carrier proteinShort name: OGCP Alternative name(s): Mitochondrial substrate carrier family protein ucpC Solute carrier family 25 member 11 homolog |
Gene namesi | Name:ucpC Synonyms:slc25a11 ORF Names:DDB_G0284225 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0284225, ucpC |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: dictyBase
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 79 – 99 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 125 – 145 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 185 – 205 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 225 – 245 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 281 – 301 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328692 | 1 – 318 | Probable mitochondrial 2-oxoglutarate/malate carrier proteinAdd BLAST | 318 |
Proteomic databases
PaxDbi | Q54PY7 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 22 – 111 | Solcar 1Add BLAST | 90 | |
Repeati | 119 – 210 | Solcar 2Add BLAST | 92 | |
Repeati | 219 – 309 | Solcar 3Add BLAST | 91 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0759, Eukaryota |
HOGENOMi | CLU_015166_14_1_1 |
InParanoidi | Q54PY7 |
OMAi | LMTVGQI |
PhylomeDBi | Q54PY7 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
Q54PY7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSFNTQNKN VLQTPIPAPT PQSQLKQFVI GGLAGMLSSA FTHPIDSLKV
60 70 80 90 100
RMQLQGEGTG VGPKRGALKM LVHINQTEGF FTLYKGLSAS LLRQATYTTT
110 120 130 140 150
RFGLYDLIKD IVAKDDKPLP FTQKIMVGML SGAGGAIVGT PADLTMVRMQ
160 170 180 190 200
ADGKLPFNLR RNYKNVFDGI FRISKEEGII SLWKGCSPNL IRAMFMTAGQ
210 220 230 240 250
VSSYDQTKQL MLASGYFHDD IKTHLIASTT AAFVAAVATS PLDVIKTRIM
260 270 280 290 300
NSPKTVTGEL QYKGTFDCLS KTLRAEGFKA FYKGFNPYFM RLGPQTILTF
310
IFVEQLNILW KKSQSYFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000064 Genomic DNA Translation: EAL65301.1 |
RefSeqi | XP_638658.1, XM_633566.1 |
Genome annotation databases
EnsemblProtistsi | EAL65301; EAL65301; DDB_G0284225 |
GeneIDi | 8624487 |
KEGGi | ddi:DDB_G0284225 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000064 Genomic DNA Translation: EAL65301.1 |
RefSeqi | XP_638658.1, XM_633566.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 44689.DDB0234071 |
Proteomic databases
PaxDbi | Q54PY7 |
Genome annotation databases
EnsemblProtistsi | EAL65301; EAL65301; DDB_G0284225 |
GeneIDi | 8624487 |
KEGGi | ddi:DDB_G0284225 |
Organism-specific databases
dictyBasei | DDB_G0284225, ucpC |
Phylogenomic databases
eggNOGi | KOG0759, Eukaryota |
HOGENOMi | CLU_015166_14_1_1 |
InParanoidi | Q54PY7 |
OMAi | LMTVGQI |
PhylomeDBi | Q54PY7 |
Enzyme and pathway databases
Reactomei | R-DDI-1614517, Sulfide oxidation to sulfate R-DDI-428643, Organic anion transporters R-DDI-70263, Gluconeogenesis |
Miscellaneous databases
PROi | PR:Q54PY7 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | M2OM_DICDI | |
Accessioni | Q54PY7Primary (citable) accession number: Q54PY7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families