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UniProtKB - Q54PF1 (CK2B_DICDI)
Protein
Casein kinase II subunit beta
Gene
csnk2b
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
By similarityGO - Molecular functioni
- protein kinase regulator activity Source: GO_Central
GO - Biological processi
- regulation of protein serine/threonine phosphatase activity Source: GO_Central
Enzyme and pathway databases
Reactomei | R-DDI-2514853, Condensation of Prometaphase Chromosomes R-DDI-6798695, Neutrophil degranulation R-DDI-6804756, Regulation of TP53 Activity through Phosphorylation R-DDI-8934903, Receptor Mediated Mitophagy R-DDI-8948751, Regulation of PTEN stability and activity |
Names & Taxonomyi
Protein namesi | Recommended name: Casein kinase II subunit betaShort name: CK II beta |
Gene namesi | Name:csnk2b ORF Names:DDB_G0284601 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0284601, csnk2b |
Subcellular locationi
Nucleus
- nucleus Source: dictyBase
Other locations
- cytoplasm Source: GO_Central
- protein kinase CK2 complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000330664 | 1 – 268 | Casein kinase II subunit betaAdd BLAST | 268 |
Proteomic databases
PaxDbi | Q54PF1 |
Interactioni
Subunit structurei
Casein kinase II/CK2 is a tetramer composed of two alpha subunit and two beta subunits.
By similarityProtein-protein interaction databases
STRINGi | 44689.DDB0216346 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 222 – 268 | DisorderedSequence analysisAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the casein kinase 2 subunit beta family.Curated
Phylogenomic databases
eggNOGi | KOG3092, Eukaryota |
HOGENOMi | CLU_034027_3_2_1 |
InParanoidi | Q54PF1 |
OMAi | WIHWFCK |
PhylomeDBi | Q54PF1 |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54PF1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRKYKDTSS EEEDSLNEDE MAWIPWYCNL KGNEFFATID EDYINDDFNL
60 70 80 90 100
TGLSSLVQFY DSALGIILDS DPDDPLSEDQ QEALERSADI LYGLIHARYI
110 120 130 140 150
LTPKGLAHMH EKFKKAEFGR CPRVFCQNQP VLPVGLADMQ GVDTVKVYCP
160 170 180 190 200
RCNDIFNPKY RRHSHIDGAY FGTTFPHLLL ITYPELIPTK PPQQYIPKIY
210 220 230 240 250
GFKIHKSARE RQLQIQQKKN SLSNNNQNNQ NNNINNNNNN NNNNNNNNNN
260
NNNNQQNNNN QQNNNTNK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000069 Genomic DNA Translation: EAL65139.1 |
RefSeqi | XP_638493.1, XM_633401.1 |
Genome annotation databases
EnsemblProtistsi | EAL65139; EAL65139; DDB_G0284601 |
GeneIDi | 8624673 |
KEGGi | ddi:DDB_G0284601 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000069 Genomic DNA Translation: EAL65139.1 |
RefSeqi | XP_638493.1, XM_633401.1 |
3D structure databases
AlphaFoldDBi | Q54PF1 |
SMRi | Q54PF1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0216346 |
Proteomic databases
PaxDbi | Q54PF1 |
Genome annotation databases
EnsemblProtistsi | EAL65139; EAL65139; DDB_G0284601 |
GeneIDi | 8624673 |
KEGGi | ddi:DDB_G0284601 |
Organism-specific databases
dictyBasei | DDB_G0284601, csnk2b |
Phylogenomic databases
eggNOGi | KOG3092, Eukaryota |
HOGENOMi | CLU_034027_3_2_1 |
InParanoidi | Q54PF1 |
OMAi | WIHWFCK |
PhylomeDBi | Q54PF1 |
Enzyme and pathway databases
Reactomei | R-DDI-2514853, Condensation of Prometaphase Chromosomes R-DDI-6798695, Neutrophil degranulation R-DDI-6804756, Regulation of TP53 Activity through Phosphorylation R-DDI-8934903, Receptor Mediated Mitophagy R-DDI-8948751, Regulation of PTEN stability and activity |
Miscellaneous databases
PROi | PR:Q54PF1 |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CK2B_DICDI | |
Accessioni | Q54PF1Primary (citable) accession number: Q54PF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families