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UniProtKB - Q54PA0 (MPI_DICDI)
Protein
Probable mannose-6-phosphate isomerase
Gene
mpi
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
By similarityCatalytic activityi
- EC:5.3.1.8
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
: GDP-alpha-D-mannose biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate. This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 141 | ZincBy similarity | 1 | |
Metal bindingi | 143 | ZincBy similarity | 1 | |
Metal bindingi | 168 | ZincBy similarity | 1 | |
Metal bindingi | 295 | ZincBy similarity | 1 | |
Active sitei | 314 | By similarity | 1 |
GO - Molecular functioni
- mannose-6-phosphate isomerase activity Source: dictyBase
- zinc ion binding Source: InterPro
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- cell wall mannoprotein biosynthetic process Source: GO_Central
- GDP-mannose biosynthetic process Source: dictyBase
- protein glycosylation Source: GO_Central
Keywordsi
Molecular function | Isomerase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-DDI-446205, Synthesis of GDP-mannose |
UniPathwayi | UPA00126;UER00423 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable mannose-6-phosphate isomerase (EC:5.3.1.8)Alternative name(s): Phosphohexomutase Phosphomannose isomerase Short name: PMI |
Gene namesi | Name:mpi ORF Names:DDB_G0284685 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0284685, mpi |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000327494 | 1 – 452 | Probable mannose-6-phosphate isomeraseAdd BLAST | 452 |
Proteomic databases
PaxDbi | Q54PA0 |
PRIDEi | Q54PA0 |
Family & Domainsi
Sequence similaritiesi
Belongs to the mannose-6-phosphate isomerase type 1 family.Curated
Phylogenomic databases
eggNOGi | KOG2757, Eukaryota |
HOGENOMi | CLU_026967_2_1_1 |
InParanoidi | Q54PA0 |
OMAi | MEEVRVF |
PhylomeDBi | Q54PA0 |
Family and domain databases
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR001250, Man6P_Isoase-1 IPR016305, Mannose-6-P_Isomerase IPR018050, Pmannose_isomerase-type1_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR10309, PTHR10309, 1 hit |
Pfami | View protein in Pfam PF01238, PMI_typeI, 1 hit |
PIRSFi | PIRSF001480, Mannose-6-phosphate_isomerase, 1 hit |
PRINTSi | PR00714, MAN6PISMRASE |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR00218, manA, 1 hit |
PROSITEi | View protein in PROSITE PS00966, PMI_I_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54PA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENNNNNNNN NNNNNNNNNN IVLLKCVSQN YEWGKYGSNS TVAKLLKGYA
60 70 80 90 100
KECSDIIKET IPYAELWMGD HVSAPSKVEY KNKELKLREY IDTVQKEINE
110 120 130 140 150
KSSTSSSSSS SIRGEIVEKR FGNDFPFLFK VLSIRTALSI QAHPDSQLAQ
160 170 180 190 200
VLFKKYPNIY KDPYHKPEIA IATTPFEALC SFRPLSEIQS FIDTIPEFKN
210 220 230 240 250
SLPNNLIKLD DCKEYLKSIV TSLLKADGLL ISNNLKELNN RLNEKREEER
260 270 280 290 300
DDLDRLVLKL YSQYPGDVGV FFAYILNYIV LKPGEALFLG AGEPHAYISG
310 320 330 340 350
DCVECMAPSD NVVRAGLTPK LKDVDTLGDM LTYRTGRPDL VVPQQRPDLS
360 370 380 390 400
LTNYRCYQPP VDEFQVEYYH LDDCCKNINV YSSKGPSIVL VYSGNLSIEN
410 420 430 440 450
KSNQSTLNNL HTGSILFVPA NTDYQFIQSD SSIPVSIYVA SVSNRIFNKN
NL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000070 Genomic DNA Translation: EAL65112.1 |
RefSeqi | XP_638475.1, XM_633383.1 |
Genome annotation databases
EnsemblProtistsi | EAL65112; EAL65112; DDB_G0284685 |
GeneIDi | 8624726 |
KEGGi | ddi:DDB_G0284685 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000070 Genomic DNA Translation: EAL65112.1 |
RefSeqi | XP_638475.1, XM_633383.1 |
3D structure databases
SMRi | Q54PA0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0231659 |
Proteomic databases
PaxDbi | Q54PA0 |
PRIDEi | Q54PA0 |
Genome annotation databases
EnsemblProtistsi | EAL65112; EAL65112; DDB_G0284685 |
GeneIDi | 8624726 |
KEGGi | ddi:DDB_G0284685 |
Organism-specific databases
dictyBasei | DDB_G0284685, mpi |
Phylogenomic databases
eggNOGi | KOG2757, Eukaryota |
HOGENOMi | CLU_026967_2_1_1 |
InParanoidi | Q54PA0 |
OMAi | MEEVRVF |
PhylomeDBi | Q54PA0 |
Enzyme and pathway databases
UniPathwayi | UPA00126;UER00423 |
Reactomei | R-DDI-446205, Synthesis of GDP-mannose |
Miscellaneous databases
PROi | PR:Q54PA0 |
Family and domain databases
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR001250, Man6P_Isoase-1 IPR016305, Mannose-6-P_Isomerase IPR018050, Pmannose_isomerase-type1_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR10309, PTHR10309, 1 hit |
Pfami | View protein in Pfam PF01238, PMI_typeI, 1 hit |
PIRSFi | PIRSF001480, Mannose-6-phosphate_isomerase, 1 hit |
PRINTSi | PR00714, MAN6PISMRASE |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR00218, manA, 1 hit |
PROSITEi | View protein in PROSITE PS00966, PMI_I_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MPI_DICDI | |
Accessioni | Q54PA0Primary (citable) accession number: Q54PA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families